Opportunities for Neurodevelopmental Plasticity From Infancy Through Early Adulthood

Guyer, Amanda E.; Pérez‐Edgar, Koraly; Crone, Eveline A.

doi:10.1111/cdev.13073

Cited by 40 publications

(28 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human infancy represents a period of rapid brain maturation including synaptogenesis, myelination and the establishment of patterns of network activation, which include frontal regions 47 . These developmental changes sub-serve the emergence of cognitive functions including early language development, attention, working memory and self-regulation 48 , all of which are strongly implicated in neuropsychiatric disorders. Interestingly, our conditional analyses show that the genes driving this increase in expression during infancy are independent to those driving the negative correlation between expression and psychiatric disorder in later childhood.…”

Section: Discussionmentioning

confidence: 99%

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development

et al. 2019

View full text Add to dashboard Cite

Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders. It has been hypothesised that genetic variants conferring risk for these disorders do so by influencing brain development, leading to the later emergence of symptoms. The comparative profile of risk gene expression for schizophrenia and bipolar disorder across development over different brain regions however remains unclear. Using genotypes derived from genome-wide associations studies of the largest available cohorts of patients and control subjects, we investigated whether genes enriched for schizophrenia and bipolar disorder association show a bias for expression across any of 13 developmental stages in prefrontal cortical and subcortical brain regions. We show that genetic association with schizophrenia is positively correlated with expression in the prefrontal cortex during early midfetal development and early infancy, and negatively correlated with expression during late childhood, which stabilises in adolescence. In contrast, risk-associated genes for bipolar disorder did not exhibit a bias towards expression at any prenatal stage, although the pattern of postnatal expression was similar to that of schizophrenia. These results highlight the dynamic expression of genes harbouring risk for schizophrenia and bipolar disorder across prefrontal cortex development and support the hypothesis that prenatal neurodevelopmental events are more strongly associated with schizophrenia than bipolar disorder.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In particular, it is important to examine patterns of brain connectivity as they develop over the course of adolescence in order to use precision mental health approaches to identify vulnerable adolescents as early as possible. Adopting a longitudinal approach, we can measure developing neurobiological signatures that may, over time, contribute to or be shaped by depression (Gotlib & Ordaz, 2016; Guyer, Pérez‐Edgar, & Crone, 2018); we can also capture heterogeneity in depression as it emerges. At this point, despite a growing recognition that depression is a disorder of brain circuits (Williams, 2017), there are few longitudinal studies of the relation between within‐person changes in network function or structure and depression in adolescents.…”

Section: Emerging Work and Future Directions: Toward A Precision Mentmentioning

confidence: 99%

Research Review: Brain network connectivity and the heterogeneity of depression in adolescence – a precision mental health perspective

Chahal

Gotlib

Guyer

2020

Child Psychology Psychiatry

Self Cite

View full text Add to dashboard Cite

Background Adolescence is a period of high risk for the onset of depression, characterized by variability in symptoms, severity, and course. During adolescence, the neurocircuitry implicated in depression continues to mature, suggesting that it is an important period for intervention. Reflecting the recent emergence of ‘precision mental health’ – a person‐centered approach to identifying, preventing, and treating psychopathology – researchers have begun to document associations between heterogeneity in features of depression and individual differences in brain circuitry, most frequently in resting‐state functional connectivity (RSFC). Methods In this review, we present emerging work examining pre‐ and post‐treatment measures of network connectivity in depressed adolescents; these studies reveal potential intervention‐specific neural markers of treatment efficacy. We also review findings from studies examining associations between network connectivity and both types of depressive symptoms and response to treatment in adults, and indicate how this work can be extended to depressed adolescents. Finally, we offer recommendations for research that we believe will advance the science of precision mental health of adolescence. Results Nascent studies suggest that linking RSFC‐based pathophysiological variation with effects of different types of treatment and changes in mood following specific interventions will strengthen predictions of prognosis and treatment response. Studies with larger sample sizes and direct comparisons of treatments are required to determine whether RSFC patterns are reliable neuromarkers of treatment response for depressed adolescents. Although we are not yet at the point of using RSFC to guide clinical decision‐making, findings from research examining the stability and reliability of RSFC point to a favorable future for network‐based clinical phenotyping. Conclusions Delineating the correspondence between specific clinical characteristics of depression (e.g., symptoms, severity, and treatment response) and patterns of network‐based connectivity will facilitate the development of more tailored and effective approaches to the assessment, prevention, and treatment of depression in adolescents.

show abstract

“…It is possible that puberty, independent of its hormonal corollaries, may display unique associations with stress exposure. Perhaps stress exposure at age 8 years, during a period of neuroendocrine quiescence and neural plasticity (Guyer, Pérez‐Edgar, & Crone, 2018), may not be potent enough to exert an impact on psychophysiology (Fuhrmann et al., 2015). Alternatively, a more severe level of stress exposure may be needed to reveal positive associations between puberty and stress than we observed in this community sample.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal effects of family psychopathology and stress on pubertal maturation and hormone coupling in adolescent twins

Phan

Hulle

Shirtcliff

et al. 2020

Developmental Psychobiology

View full text Add to dashboard Cite

Adolescents experience profound neuroendocrine changes, including hormone "coupling" between cortisol, testosterone, and dehydroepiandrosterone. Emerging research has only begun to elucidate the role of hormone coupling, its genetic and environmental etiology, and the extent to which coupling is impacted by gender, puberty, and family context. We included measures on parent and child mental health, parenting stress, and family conflict of 444 twin pairs and their parents across two timepoints, when youth were on average 8 and 13 years old, respectively. Structural equation models examined the impact of family context effects on coupling during adolescence. Biometric twin models were then used to probe additive genetic, shared, and non-shared environmental effects on hormone coupling. Hormones were more tightly coupled for females than males, and coupling was sensitive to parental depression and co-twin psychopathology symptoms and stress exposure in females. The association between family context and coupling varied across specific neuroendocrine measures and was largely distinct from pubertal maturation. Biometric models revealed robust shared and non-shared environmental influences on coupling. We found that family antecedents modify the strength of coupling. Environmental influences account for much of the variation on coupling during puberty. Gender differences were found in genetic influences on coupling.

show abstract

Opportunities for Neurodevelopmental Plasticity From Infancy Through Early Adulthood

Cited by 40 publications

References 46 publications

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development

Research Review: Brain network connectivity and the heterogeneity of depression in adolescence – a precision mental health perspective

Longitudinal effects of family psychopathology and stress on pubertal maturation and hormone coupling in adolescent twins

Contact Info

Product

Resources

About