Computer Science, as a single discipline, can no longer speak to the broad relevance of digital technologies in society. The Department of Informatics in the Donald Bren School of Information and Computer Sciences at the University of California, Irvine, serves as the institutional home for research on relationships between technological, organizational, and social aspects of information technology. Here, we describe the research landscape of the Department of Informatics and its relation to the diverse field of Human-Computer Interaction.