2017
DOI: 10.1002/cne.24341
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Opposing expression gradients of calcitonin‐related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea

Abstract: Type II spiral ganglion neurons (SGNs) are small caliber, unmyelinated afferents that extend dendritic arbors hundreds of microns along the cochlear spiral, contacting many outer hair cells (OHCs). Despite these many contacts, type II afferents are insensitive to sound and only weakly depolarized by glutamate release from OHCs. Recent studies suggest that type II afferents may be cochlear nociceptors, and can be excited by ATP released during tissue damage, by analogy to somatic pain-sensing C-fibers. The pres… Show more

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Cited by 24 publications
(39 citation statements)
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“…6. Similar to Th and Cgrpα (also known as Calca) 12 , Slc6a4-GFP and Drd2-Cre also showed specific expression gradients along the cochlear coil (as summarized in Fig. 6c).…”
Section: Resultsmentioning
confidence: 81%
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“…6. Similar to Th and Cgrpα (also known as Calca) 12 , Slc6a4-GFP and Drd2-Cre also showed specific expression gradients along the cochlear coil (as summarized in Fig. 6c).…”
Section: Resultsmentioning
confidence: 81%
“…The expression pattern of Slc6a4-GFP cochleas was examined in pre-hearing (P7–9) and hearing mice (P30–45). GFP-expressing SGNs were counted in bins by dividing the cochlear whole mounts into 10 segments along the tonotopic axis using ImageJ, as described previously 12 . Representative images of apical, mid and basal turns of cochlea with labeled SGNs in pre-hearing mice are shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
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