Opposite effects of nanocrystalline fullerene (C60) on tumour cell growth in vitro and in vivo and a possible role of immunosupression in the cancer-promoting activity of C60

Zogović, Nevena; Nikolić, Nadežda; Vranješ-Đurić, Sanja; Harhaji, Ljubica; Vučićević, Ljubica; Janjetović, Kristina; Misirkić, Maja; Marković, Biljana M. Todorović; Marković, Zoran M.; Milonjić, Slobodan K.; Trajkovič, Vladimir

doi:10.1016/j.biomaterials.2009.09.007

Cited by 46 publications

(38 citation statements)

References 27 publications

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“…Based on our findings, it is plausible to suggest that TiO 2 nanoparticles could enhance tumor growth via effects on host immune cells leading to altered tumor immunosurveillance. These results are in accordance with a previous report that nanocrystalline fullerene suspensions could potentiate tumor growth in vivo, possibly by causing an NO-dependent suppression of anticancer immune responses (Zogovic et al, 2009). …”

Section: Discussionsupporting

confidence: 83%

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

Moon

Kang

et al. 2011

Journal of Immunotoxicology

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Section: Discussionsupporting

confidence: 83%

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

Moon

Kang

et al. 2011

Journal of Immunotoxicology

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“…Aluminum NPs have been shown to impair phagocytosis and alter immune responses in alveolar cocultures; inhaled carbon NPs have been implicated in decreased bacterial clearance; mice that inhaled carbon nanotubes showed systemic suppression of immune function through activation of the cyclooxygenase pathway; systemic administration of durable carbon NPs (a fullerene derivative) led to enhanced tumor growth via immunosuppressive effects that were also seen with titanium dioxide NPs. [15][16][17][18][19] The bio-persistence of NPs in macrophages of the MPS without accompanying macrophage functional studies raises questions regarding the effects of NPs-containing drugs.…”

Section: Introductionmentioning

confidence: 99%

Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro

Bancos¹,

Stevens²,

Tyner³

2014

IJN

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The accumulation of durable nanoparticles (NPs) in macrophages following systemic administration is well described. The ultimate biological impact of this accumulation on macrophage function, however, is not fully understood. In this study, nontoxic doses of two durable NPs, SiO 2 and Au, at particle sizes of ~10 nm and 300 nm were used to evaluate the effect of bioaccumulation on macrophage function in vitro using RAW 264.7 mouse macrophage-like cells as a model system. Cell proliferation, cell cycle, cytokine production, surface marker activation, and phagocytosis responses were evaluated through a panel of assays using flow cytometry and confocal microscopy. The most dramatic change in RAW 264.7 cell function was a reduction in phagocytosis as monitored by the uptake of Escherichia coli . Cells exposed to both 10 nm Au NPs and 10 nm SiO 2 NPs showed ~50% decrease in phagocytosis, while the larger NPs caused a less dramatic reduction. In addition to modifying phagocytosis profiles, 10 nm SiO 2 NPs caused changes in proliferation, cell cycle, and cell morphology. Au NPs had no effect on cell cycle, cytokine production, or surface markers and caused interference in phagocytosis in the form of quenching when the assay was performed via flow cytometry. Confocal microscopy analysis was used to minimize this interference and demonstrated that both sizes of Au NPs decreased the phagocytosis of E. coli . Overall, our results demonstrate that Au and SiO 2 NP uptake by macrophages can influence macrophage phagocytosis in vitro without altering surface markers and cytokine production in vitro. While the biological impact of these findings remains unclear, our results indicate that bioaccumulation of durable NPs within the macrophages may lead to a suppression of bacterial uptake and possibly impair bactericidal activity.

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“…Moreover, nanoC60 synergized with the anticancer factor in killing the cancer cells, but not normal cells [4]. Recent studies have suggested that nanoC60 might be a potential candidate for the selective anticancer therapy [5]. And there water solubility is enhanced, which makes such molecules amenable to biological studies [6,7].…”

Section: Introductionmentioning

confidence: 98%

Preparation and Radical Scavenging Activity of Nano-Fuller-Serine

Zhang

et al. 2012

2012 International Conference on Biomedical Engineering and Biotechnology

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The fuller-serine was synthesized and then dissolved in the organic solvent and then the nanoparticle aqueous suspension of fuller-serine was prepared. The nanoparticle sizes and Zeta-potentials were obtained by TEM and a Zeta-patential instrument, respectively. The results indicated that the aqueous nano-particle suspensions were rather considerably stable with homogeneous size. The free radicals scavenging of nano fuller-serine were determined by means of pyrogallol oxidation. The result indicated it was useful to scanvenge oxygen free radicals in a concentration dependent manner. Whether they are able to protect biological systems from oxidative damages or not needs to be further investigated.

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Opposite effects of nanocrystalline fullerene (C60) on tumour cell growth in vitro and in vivo and a possible role of immunosupression in the cancer-promoting activity of C60

Cited by 46 publications

References 27 publications

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro

Preparation and Radical Scavenging Activity of Nano-Fuller-Serine

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