Opposite effects of short- and long-duration isolation on ultrasonic vocalization, startle and prepulse inhibition in rats

Tomazini, Fernanda Mariana; Reimer, Adriano E.; Albrechet‐Souza, Lucas; Brandão, Marcus Lira

doi:10.1016/j.jneumeth.2005.10.007

Cited by 27 publications

(25 citation statements)

References 48 publications

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“…These effects were all reduced by prior injections of the selective NK-3 receptor antagonist SB222200 into the dPAG. It is also important to mention that the fact that the use of young adult rats in this study might have had an impact on the reported results especially because it is known that the spontaneous behavior of rats at this age is highly influenced by their emotional reactivity (Adriani and Laviola 2004;Tomazini et al 2006). Nonetheless, more studies are needed to firmly establish the role of NK-3 receptors and its endogenous agonist neurokinin B.…”

Section: Discussionmentioning

confidence: 97%

“…Rats emit USVs at frequencies of 20-24 kHz when exposed to moderately stressful conditions, such as when they are exposed to potentially dangerous situations (Blanchard et al 1991;Vivian et al 1994;Brudzynski and Chiu 1995;Commissaris et al 2000;Nobre and Brandão 2004). However, a nonmonotonic function may ensue when rats with past stressful experience are exposed to threatening conditions of an intense nature (Nunes Mamede Rosa et al 2005;Tomazini et al 2006). Thus, an intense condition of fear or proximal danger, such as when the animals are confronted by predators, produces opposite effects (i.e., a reduction in USVs at 22-24 kHz) that are not sensitive to the anxiolytic effects of midazolam (Tomazini et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…However, a nonmonotonic function may ensue when rats with past stressful experience are exposed to threatening conditions of an intense nature (Nunes Mamede Rosa et al 2005;Tomazini et al 2006). Thus, an intense condition of fear or proximal danger, such as when the animals are confronted by predators, produces opposite effects (i.e., a reduction in USVs at 22-24 kHz) that are not sensitive to the anxiolytic effects of midazolam (Tomazini et al 2006). Consistent with this, rats have been claimed to only emit 22 kHz vocalizations under experimental conditions associated with anxiety and not fear (Jelen et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…An important component of the defensive behavior repertoire of rats and a reliable measure of anxiety-like behavior in myomorph rodents is the phenomenon of ultrasonic vocalizations (USVs), more specifically 22 kHz vocalizations (van der Poel et al 1989;Blanchard et al 1991;Commissaris et al 2000;Brudzynski and Chiu 1995;Wohr et al 2005;Tomazini et al 2006). Rats emit vocalizations of approximately 22 kHz only under experimental conditions of potential or distal threat, not immediate or proximal threat, suggesting that these vocalizations are associated with anxiety rather than fear (Jelen et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats

et al. 2008

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats

et al. 2008

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“…Rats reared in social isolation exhibit distinct behaviors compared with socially reared ones [3][4][5][6][7], such as depressive-like behaviors [8][9][10], different levels of anxiety [11,12], increased negative states [13,14], enhanced aggressive response [15], and cognitive impairments [4].…”

mentioning

confidence: 99%

Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats

Wen

2010

Chin. Sci. Bull.

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Studies on social isolation have provided evidence for an enhanced anxiety-like phenotype, depressive-like symptoms and higher levels of 22-kHz ultrasonic vocalizations (USVs); whereas sexual experience could induce significant changes in affective states, decrease anxiety-and depressive-like responses. However, the behavioral and emotional alterations in male rats exposed to isolation after sexual experience remain poorly understood. Therefore, the present study examined anxiety-and depressive-like parameters, as well as USV emissions in male rats isolated for 1, 2, or 7 d following 1-week sexual (male-female paired housing) or social (male-male paired housing) interaction. Isolation for 1 d resulted in increased depressive-like symptoms, and 2-d isolation induced elevated anxiety-like behavior in sexually inexperienced rats, while rats with sexual experience exhibited comparable levels of emotionality at each isolation time. Moreover, isolated rats without sexual experience emitted less 22-and 50-kHz USVs, but sexually experienced rats exhibited similar affective states compared with control ones. These results suggested that prior sexual experience could have a modulatory effect on experimental rat emotional responses to isolation. social isolation, sexual experience, anxiety-like, depressive-like, ultrasonic vocalization (USV) Citation:Wen F, Xu L. Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats.

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Acoustic Communication in Rats: Effects of Social Experiences on Ultrasonic Vocalizations as Socio-affective Signals

Wöhr

Engelhardt

Seffer

et al. 2015

Current Topics in Behavioral Neurosciences

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Ultrasonic vocalizations (USV) serve important communicative functions as socio-affective signals in rats. In aversive situations, such as inter-male aggression and predator exposure, 22-kHz USV are emitted. They likely function as appeasement signals during fighting and/or as alarm calls to warn conspecifics. In appetitive situations, 50-kHz USV are uttered, most notably during social interactions, such as rough-and-tumble play and mating. It is believed that they fulfill an affiliative function as social contact calls. Social experiences or their lack, such as social isolation, can have profound impact on the emission of 22- and 50-kHz USV by the sender in later life, albeit direction and strength of observed effects vary, with time point of occurrence and duration being critical determinants. Little, however, is known about how social experiences affect the behavioral responses evoked by 22- and 50-kHz USV in the recipient. By means of our 50-kHz USV radial maze playback paradigm, we recently showed that the behavioral response elicited in the recipient is affected by post-weaning social isolation. Rats exposed to four weeks of isolation during the rough-and-tumble play period did not display social approach behavior toward 50-kHz USV but some signs of social avoidance. We further found that physical environmental enrichment providing minimal opportunities for social interactions has similar detrimental effects. Together, this indicates that social experiences can affect socio-affective communication in rodents, both at the level of sender and recipient. Deficits seen following post-weaning social isolation or physical environmental enrichment might be useful to model aspects of neurodevelopmental disorders characterized by social and communication deficits, such as autism and schizophrenia.

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Opposite effects of short- and long-duration isolation on ultrasonic vocalization, startle and prepulse inhibition in rats

Cited by 27 publications

References 48 publications

Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats

Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats

Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats

Acoustic Communication in Rats: Effects of Social Experiences on Ultrasonic Vocalizations as Socio-affective Signals

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