Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum

Monteleone, Palmiero; Fabrazzo, Michele; Tortorella, Alfonso; Fuschino, Antonio; Maj, Mario

doi:10.1038/sj.mp.4001043

Cited by 82 publications

(49 citation statements)

References 30 publications

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“…Data from the study by Monteleone et al are consistent with our findings. These authors observed in AN patients low concentrations of leptin and increased values of leptin receptor [19]. Our results also corroborate with those of the group of Misra, who reported a markedly reduced plasma leptin concentration coexisting with enhanced concentration of sOB-R and decreased FLI in AN participants in comparison with healthy adolescents [17].…”

Section: Prace Oryginalnesupporting

confidence: 92%

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Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissuederived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay. Results: Leptin and free leptin index (FLI) were lowest in treatment-naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group. Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content. (Endokrynol Pol 2017; 68 (4): 422-429)

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Section: Prace Oryginalnesupporting

confidence: 92%

“…A correlation between decreased BMI and low levels of leptin were also described in accessible literature [15][16][17][18][19].…”

Section: Prace Oryginalnementioning

confidence: 88%

Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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“…This is probably because B vitamins are known to increase appetite [15], possibly leading to weight gain and/or obesity and hence, indirectly increasing leptin levels. The circulating levels of leptin have been shown to be influenced by amount of body fat, with higher levels in obese than in lean individuals [29]. However, conflicting findings are reported for leptin concentration differences with similar fat mass [30,31].…”

Section: Resultsmentioning

confidence: 99%

Assessment of selected nutrient intake and adipocytokine profile among Saudi children and adults

et al. 2012

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A BALANCED DIET, including normal intake of essential amino acids, carbohydrates, essential fatty acids, vitamins and minerals, is important to maintain health and a sensible body weight. However, nutritional needs vary from one life stage to another. The scarcity or excessive intake in any of these substances could disturb the nutritional and metabolic homeostasis of the body and lead to increased risk for several pathologic conditions. Thus, dietary modification presents a powerful means by which we can minimize or prevent the onset of several risk factors for different disAssessment of selected nutrient intake and adipocytokine profile among Saudi children and adults Nasser M. Al-Daghri 1), 2), 3) , Abdulaziz Al-Othman 2), 4) , Khalid M. Alkharfy 1), 2), 5) , Majed S. Alokail 1), 2), 3) , Nasiruddin Khan 2) , Hanan A Alfawaz 6) , Ibrahim A. Aiswaidan 7) and George P. Chrousos 1), 8) Abstract. We report the dietary intake of selected nutrients in apparently healthy adults and children and its correlation with circulating levels of serum leptin and resistin. In this observational study, 47 Saudi children (mean age 13.1 ± 2.8 year) and 47 adults (mean age 45.7 ± 10.5 year) were recruited. Anthropometric data and lipid profile were obtained. Food intake was assessed by a food questionnaire and a 24-hour diet recall method. The dietary intake of selected nutrients was compared with the estimated average requirement (EAR) or adequate intake (AI) for establishing nutritional status. Results demonstrated that the levels of choline and calcium intake were significantly lower than the EAR in adults (p= 0.01 and 0.04, respectively) and relatively low in children. The level of manganese in adults was significantly higher (p= 0.02) than their AI level. The increasing levels of dietary vitamin B6 and B12 were associated with a significant increase in serum concentrations of leptin in adults and children (p=0.02). Overall, the dietary intakes of selected nutrients in Saudi adults and children were not adequate with most of them below cut-off EAR values except for essential amino acids.

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“…We hypothesize, therefore, that the regulation of leptin and sOB-R may be independent from one another at manifestation of T1DM and during its treatment. This must not be the case in non-diabetic subjects, where leptin or fat mass differences may influence sOB-R serum levels (27,28). The biological impact of increased sOB-R levels in newly diagnosed diabetes is presently unclear.…”

Section: Discussionmentioning

confidence: 99%

Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor

Kratzsch

Knerr²,

Galler³

et al. 2006

eur j endocrinol

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Objective: Type 1 diabetes mellitus (T1DM) leads to increased serum levels of the soluble leptin receptor (sOB-R) by an as yet unknown cellular mechanism. The aim of our study was to investigate potential metabolic factors that may be associated with the induction of the sOB-R release from its membrane receptor. Materials and methods: Twenty-five children (aged between 1.5 and 17.0 years) were studied at the onset of T1DM. Blood samples were collected before (nZ25), during the first 18 h (meanGS.D. 11.1G 4.3 h, nZ16) and 92 h (47.5G22.5 h; nZ14) after beginning insulin therapy. Serum sOB-R and leptin levels were determined by in-house immunoassays. Results: The sOBR-level and the molar sOB-R/leptin ratio were significantly higher before than after starting insulin treatment (P!0.05). In contrast, leptin levels were significantly lower (P!0.05) before insulin therapy. The correlation between sOB-R and blood glucose (rZ0.49; P!0.05), as well as sOB-R with parameters of ketoacidosis, such as pH (rZK0.72), base excess (rZK0.70), and bicarbonate (rZK0.69) (P!0.0001) at diagnosis of T1DM remained significant during the first 18 h of insulin treatment. Multiple regression analysis revealed that base excess predicted 41.0% (P!0.001), age 16.4% (P!0.05), and height SDS 13.9% (P!0.01) of the sOB-R variance. Conclusions: Metabolic decompensation in children with new onset T1DM is associated with dramatic changes of the leptin axis; serum levels of sOB-R are elevated and of leptin are reduced. The molar excess of sOB-R over leptin (median 11.3) in this condition may contribute to leptin insensitivity. Upregulation of the soluble leptin receptor appears to be a basic mechanism to compensate for intracellular substrate deficiency and energy-deprivation state.European Journal of Endocrinology 155 609-614

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Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum

Cited by 82 publications

References 30 publications

Adipokine profile in patients with anorexia nervosa

Adipokine profile in patients with anorexia nervosa

Assessment of selected nutrient intake and adipocytokine profile among Saudi children and adults

Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor

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