Opsomyoclonus and Neuroblastoma

Abstract

Three cases of neuroblastoma with opsomyoclonus are reported, reconfirming favorable prognostic significance of the association. In one case, computed tomography of the abdomen was the only confirmatory diagnostic study. Two of the cases also were unusual in that the patients had a concomitantly inherited genetic disorder not known to be associated with childhood cancer.

Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: A report from the Pediatric Oncology Group

“…The characteristic findings of this syndrome warrant the label ''dancing eyes, dancing feet''. The OM syndrome has been associated with a variety of neoplasms including breast and ovarian carcinoma [1,2]. In children, the most common associated neoplasm is neuroblastoma.…”

A unique presentation of neuroblastoma in Turner syndrome: A case report

“…This imaging confirmed local extension TS is a genetic disorder seen in females, characterised by partial or complete deletion of the X chromosome. The association between TS and neurogenic tumours has been reported in the literature, [1][2][3][4][5][6] however still lacks a definitive relationship. 2 This case is distinct, given the absence of clarity surrounding a final histopathological subtype and atypical nuclear medicine findings.…”

Late cognitive and adaptive outcomes of patients with neuroblastoma‐associated opsoclonus‐myoclonus‐ataxia‐syndrome: A report from the Children's Oncology Group

“…In children, there is a known association between neuroblastoma and OMAS, and 2%–4% of children diagnosed with neuroblastoma present with OMAS 4 . If a patient presents with OMAS, there is a 50% chance that an underlying peripheral neuroblastic tumor is identified 5 .…”