Optic Atrophy After Administration of Isoniazid With P.A.S.

Sutton, P.H.; Beattie, P.H.

doi:10.1016/s0140-6736(55)90321-4

Cited by 31 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isoniazid can also produce both anterior and retrobulbar optic neuropathies. Peripheral neuropathy is a well‐recognized complication of isoniazid therapy and bilateral retrobulbar optic neuropathy has been reported in patients with (Clarel, 1961) and without (Sutton and Beattie, 1955) peripheral neuropathy. Pyridoxine may protect against both effects.…”

Section: Optic Nervementioning

confidence: 99%

Ocular complications of neurological therapy

Hadjikoutis¹,

Morgan

Wild

et al. 2005

Euro J of Neurology

View full text Add to dashboard Cite

Treatments used for several neurological conditions may adversely affect the eye. Vigabatrin-related retinal toxicity leads to a visual field defect. Optic neuropathy may result from ethambutol and isoniazid, and from radiation therapy. Posterior subcapsular cataract is associated with systemic corticosteroids. Transient refractive error changes may follow treatment with acetazolamide or topiramate, and corneal deposits and keratitis with amandatine. Intraocular pressure can be elevated in susceptible individuals by anticholinergic drugs, including oxybutynin, tolterodine, benzhexol, propantheline, atropine and amitriptyline, and also by systemic corticosteroids and by topiramate. Nystagmus, diplopia and extraocular muscle palsies can occur with antiepileptic drugs, particularly phenytoin and carbamazepine. Ocular neuromyotonia can follow parasellar radiation. Congenital ocular malformations can result from in utero exposure to maternally prescribed sodium valproate, phenytoin and carbamazepine. Neurologists must be aware of potential ocular toxicity of these drugs, and appropriately monitor for potential adverse events.

show abstract

Section: Optic Nervementioning

confidence: 99%

Ocular complications of neurological therapy

Hadjikoutis¹,

Morgan

Wild

et al. 2005

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…In adults, only three papers described isoniazidinduced neuropathy of the optic nerve [4,5,10]. In the older literature, optic neuritis during isoniazid treatment was reported in two papers [6,9].…”

mentioning

confidence: 99%

Diplopia and strabismus convergens mimicking symptoms of tuberculous meningitis as side-effects of isoniazid

Dompeling¹,

Schut

Vles

et al. 2004

Eur J Pediatr

View full text Add to dashboard Cite

Tuberculosis remains the most frequent infectious cause of death in the world, has re-emerged in developed nations, and demonstrates a steady increase in incidence in children [1,7,10]. Extra-pulmonary disease has also increased and tuberculous meningitis is one of the presentations with a high morbidity and mortality [1,7]. Symptoms of tuberculous meningitis are not very specific and may include weight loss, fatigue, rigidity and signs of cranial nerve palsy [7]. Early diagnosis of tuberculous meningitis is essential for the cure of children and/or the prevention of neurological deficits.A 7-year-old boy presented at the outpatient clinic of the Department of Ophthalmology of our hospital with complaints of strabismus convergens and horizontal diplopia. For 6 weeks he was known to doctors of the Agency for Tuberculosis Control because of a strongly positive Mantoux test (18 mm swelling with induration and redness) but a normal chest X-ray film. These investigations were carried out because his stepfather appeared to have active lung tuberculosis. Our case had not received a BCG vaccination in the past. The boy was treated with isoniazid prophylaxis for 6 weeks at a daily dose of 150 mg (5 mg/kg). He did not use other drugs. The boy's younger brother had enlarged lymph nodes on a chest X-ray film and was treated with four tuberculostatic agents.Ophthalmological evaluation of our patient showed a left-sided abducens palsy, no movement of redress on cover-and uncover testing and bilateral haziness of the optic discs. Visual acuity was normal. Further physical and neurological examination showed discrete neck stifness. However, examination of the other cranial nerves was normal and no disturbances in muscle tone and strength, coordination, sensibility, and tendon reflexes were observed. He had no enlarged lymph nodes and lung auscultation was normal. His height was 132 cm (+1 SDS) and weight 30.7 kg (+1 SDS). To exclude a tuberculous meningitis or an intracerebral tuberculoma, he underwent MRI of the brain followed by a lumbar puncture. The MRI scan demonstrated no abnormalities: no elevated intracranial pressure, no tumour and no signs of basal meningitis. Lumbar puncture showed a normal pressure (17 cm H 2 O). The results of the CSF analysis were: 2 leucocytes/ll (66% lymphocytes, 29% granulocytes, 4% monocytes), glucose 4.0 mmol/l, protein 0.34 g/l (slightly elevated), chloride 123 mmol/l, and lactate 1.9 mmol/l. ZiehlNeelsen staining of the CSF was negative. Culture demonstrated no growth of Mycobacterium tuberculosis or growth of other possible bacterial or viral pathogens. Liver enzymes (serum alanine aminotransferase, glutamate pyruvate transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate dehydrogenase) were normal. On basis of these findings, (tuberculous) meningitis with raised intracranial pressure was excluded. Finally, we considered the possibility that isoniazid was responsible for the neurological abnormalities [3,7]. Isoniazid was stopped and replaced by rifampicine and pyridoxin...

show abstract

Dermatoses in Patients Receiving Chemotherapy for Systemic Tuberculosis

Becker¹

1957

Arch Dermatol

View full text Add to dashboard Cite

Optic Atrophy After Administration of Isoniazid With P.A.S.

Cited by 31 publications

References 0 publications

Ocular complications of neurological therapy

Ocular complications of neurological therapy

Diplopia and strabismus convergens mimicking symptoms of tuberculous meningitis as side-effects of isoniazid

Dermatoses in Patients Receiving Chemotherapy for Systemic Tuberculosis

Contact Info

Product

Resources

About