Optic Disc and Retinal Nerve Fiber Layer Parameters of Eyes With Keratoconus

Cankaya, Ali Bulent; Beyazyıldız, Emrullah; Ileri, Dilek; Yılmazbaş, Pelin

doi:10.3928/15428877-20120531-01

Cited by 14 publications

(18 citation statements)

References 18 publications

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“…In the present study, the mean RNFL thickness measurements for the nasal quadrants were almost identical in the two groups. This finding is in accordance with previous studies 3,35 which have reported less than 3 µm nasal quadrant RNFL thickness differences between individuals with keratoconus and healthy controls.…”

Section: Discussionsupporting

confidence: 83%

“…The mean RNFL measurements were marginally higher (1 µm -13 µm) in the control group for all quadrants with the exception of only the nasal quadrant in the left eye where the same value (78 µm) was noted in the two groups. This finding is consistent with reports from previous studies, 3,35 which also noted lower quadrant-specific mean RNFL thickness measurements in individuals with keratoconus when compared with healthy controls. For the superior quadrant, Bayhan et al 35 reported a 13.6 µm statistically significant (p = 0.045) RNFL thickness difference between the keratoconus and control groups which is almost identical to the difference (13 µm, p ≤ 0.015) noted for the superior quadrant of both eyes in the present study.…”

Section: Discussionsupporting

confidence: 83%

“…51,55 Few studies have measured RNFL thickness in individuals with keratoconus and these studies have reported conflicting results. The mean global RNFL thickness in the keratoconus group (~ 99 µm) in the present study is comparable to the mean value (97 µm) reported by Cankaya et al 3 in individuals with keratoconus. In contrast, Bayhan et al 35 reported a higher mean global RNFL thickness (104.44 µm).…”

Section: Discussionsupporting

confidence: 80%

“…This value is comparable to mean RNFL thickness values (range 105.5 µm -107.7 µm), also measured with OCT devices, reported in studies involving healthy Indian, 50,51 Korean 52,53 and Turkish 54 populations. Despite also using a Fourier-domain OCT device to measure the RNFL thickness, Cankaya et al 3 reported a slightly lower global RNFL thickness value (99 µm) which may be attributed to the inclusion of slightly older participants (mean age 31.5 years) and a larger sample size (n = 74) in their control group. Nevertheless, such comparisons across studies should be interpreted with caution as RNFL thickness varies with several ocular and demographic factors.…”

Section: Discussionmentioning

confidence: 99%

“…2 Assessment of the visual field may be challenging in patients with keratoconus owing to corneal opacities, high refractive errors and/or higher order aberrations. 3 Even though evaluation of optic disc photographs is a standard method to monitor optic nerve head changes in glaucoma suspects, this method may have limited usefulness in patients with keratoconus owing to poor-quality photographs and a relatively normal appearance of the optic nerve head. 4 Moreover, patients with keratoconus usually present with myopia and low intraocular pressure (IOP) measurements.…”

Section: Introductionmentioning

confidence: 99%

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Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Cuppusamy

Makhanya

Methula

et al. 2018

Afr. vis. eye health

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Background: Keratoconus, a corneal ectasia, is associated with corneal thinning and altered optical media. Consequently, assessment of the visual field, optic nerve head and intraocular pressure measurements may be challenging in patients with keratoconus. Few studies have investigated posterior segment variables including the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in patients with keratoconus.Aim: To investigate RNFL and GCC thickness in patients with keratoconus.Methods: A comparative quantitative research design was used. The sample consisted of 56 participants (28 with mild, moderate or severe keratoconus, and 28 controls) who accessed the optometry clinic at the University of KwaZulu-Natal. There was an equal distribution of male (n = 14) and female (n = 14) participants in the keratoconus and control groups. Most participants were black (n = 34) or Indian (n = 18). Corneal power and refractive error were assessed with the Oculus Keratograph and subjective refraction respectively. The iVue-100 optical coherence topography device was used to measure RNFL and GCC thickness. Data were analysed by descriptive and inferential statistics.Results: The mean global RNFL thickness was slightly higher in the control group than the keratoconus group for the right (106 µm vs. 99 µm) and left (103 µm vs. 98 µm) eyes but these differences were not significant (p ≥ 0.057). For all RNFL quadrants, slightly lower mean RNFL measurements were found in the keratoconus group. The mean GCC thicknesses were marginally higher (3 µm – 6 µm) in the control group.Conclusion: The RNFL and GCC thickness differences between patients with keratoconus and controls are not clinically significant. Therefore, abnormally reduced RNFL and GCC thickness measurements in patients with keratoconus warrant further investigation for other pathologies specifically glaucoma.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%