Optic Disc Imaging in Conscious Rats and Mice

Abstract

In addition to the application of this imaging method to studies of the effect on optic disc cupping of induced increased intraocular pressure in rats and mice, by detecting and documenting the onset and the course of optic neuropathy, it should be valuable in identifying animal models of glaucoma, in studying neuropathogenic mechanisms, and in assessing the effects of experimental therapies.

Chorioretinal Vascular Oxygen Tension Changes in Response to Light Flicker

“…23 Results obtained in one rat are shown in Figure 4. Arterial PO 2 decreased linearly with increased distance (slope, -0.04; y-intercept, 63), whereas venous PO 2 remained relatively unchanged (slope, -0.004; y-intercept, 33).…”

En face optical coherence tomography: a new method to analyse structural changes of the optic nerve head in rat glaucoma

“…[21][22][23] Chauhan et al have recently advocated the use of the HRT for in vivo assessment of ONH changes in the rat model of glaucoma. 11 However, the authors acknowledged that the limits of the depth resolution of the HRT and the complex structure of the rat ONH made the data, including volume assessment of the optic disc, difficult to interpret.…”

In vivo imaging methods to assess glaucomatous optic neuropathy

“…Thus, fundus photography in rats and mice benefits greatly from specialized equipment arrangements and procedures in order to obtain higher quality fundus images. (Cohan et al, 2003; Hawes et al, 1999; Kocaoglu et al, 2007; Paques et al, 2007) High-resolution images of the mouse or rat fundus can also be obtained by confocal scanning laser ophthalmoscopy (CSLO). (Chauhan et al, 2002; Cordeiro et al, 2004; Paques et al, 2006; Seeliger et al, 2005) Advantages of CSLO for fundus imaging include improved image contrast due the confocal aperture and relative ease of imaging through the smaller pupil due to the narrow diameter of the scanning beam; disadvantages include greater expense of CSLO systems and lack of true color reflectance since the imaging source is monochromatic, though this aspect also contributes to greater image contrast and facilitates fluorescence applications.…”