Optic Nerve Changes in Zinc-deficient Rats

Gong, Huaqing; Amemiya, Tsugio

doi:10.1006/exer.2000.0958

Cited by 28 publications

(20 citation statements)

References 21 publications

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“…In the experimental rats in the present study there was a statistically significant decrease in the serum Mg and typical signs of Mg deficiency: sudden death, jumping response to a loud sound, slightly coarse hair, edema of all four paws and necrosis of the heart muscle [13]. Pair-fed control rats showed severe weight loss but no abnormal changes in the optic nerve.…”

Section: Discussionsupporting

confidence: 48%

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Ultrastructure of the Optic Nerve in Magnesium-Deficient Rats

Gong

Takami²,

Amemiya³

2003

Ophthalmic Res

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Purpose: The ultrastructure of the optic nerves in magnesium (Mg)-deficient rats was studied to elucidate the function of Mg. Methods: After delivery, mother Wistar Kyoto rats were fed a low-Mg diet containing 0.1 mg Mg/100 g diet with all other nutrients and distilled and deionized water. Infant rats were suckled by their mothers for 21 days and then fed the same Mg-deficient diet. Control mother rats were fed commercial rat pellets containing 24 mg Mg/100 g diet and all other nutrients. The optic nerves were examined by electron microscopy at 6 weeks of age. Results: In the Mg-deficient rats, serum Mg levels were significantly lower and calcium levels higher than in the control rats. Ultrastructural findings were: significantly fewer myelinated axons and significantly thinner myelin sheaths in the Mg-deficient rats than in the control and pair-fed controls, and more numerous unmyelinated axons. There were multifocal areas of destruction and necrosis in the optic nerve of Mg-deficient rats. Conclusions: This study suggests that the optic nerve needs Mg for the development and maintenance of its cell structure.

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Section: Discussionsupporting

confidence: 48%

“…Several studies of trace elements in the eye have demonstrated the intimate relationship between them and the optic nerve [10][11][12][13]. The purpose of the present study is to show optic nerve changes in Mg-deficient rats and to examine the effect of Mg deficiency on the development of the optic nerve.…”

Section: Introductionmentioning

confidence: 85%

Ultrastructure of the Optic Nerve in Magnesium-Deficient Rats

Gong

Takami²,

Amemiya³

2003

Ophthalmic Res

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“…11,12 Trace elements deficiency, undernourishment, and exposure to drugs of abuse or alcohol induced ultrastructural changes in the ON, cornea, and retina. 25,26,29,[31][32][33][34][35][42][43][44][45][46][47][48][49][50][51][52][53] Figure 2 Mean density (a) and total number (b) of myelinated and unmyelinated fibres of the optic nerve in the control, anaemic, and recovered rats at postnatal day 32. Values are means ± SE for n ¼ 6; *Po0.05.…”

Section: Discussionmentioning

confidence: 99%

“…26 Zn-deficient rats presented myelin destruction and glial cells proliferation in the ON and change of the quantity of trace elements and vitamin C in the cornea. 47,50 The ON axons of methamphetamine-treated females had a reduction of MBP protein expression and a reduction of the myelin thickness. 33 Alcohol and methamphetamine intoxication induced abnormalities in the myelination and severe delays in the development of the retina and ON, in addition to causing ultrastructural alterations.…”

Section: Discussionmentioning

confidence: 99%

“…60 Insults, such as trace elements deficiency, malnutrition, or even altered functioning of the thyroid gland, can influence the myelination process in a persistent manner. 25,[44][45][46]53,61 Myelinogenesis continues until adolescence in both rodents 61 and humans. 62,63 It is known that myelinogenesis in the rat ON starts around PND 7, and between the second and fifth weeks of the postnatal period that a rapid increase in myelination is observed.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of iron repletion in the diet for the optic nerve development of anaemic rats

Demaman

Melo

Homem

et al. 2009

Eye

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Purpose To compare the process of myelination in the developing optic nerve (ON) of anaemic rats with the subsequent recovery after being fed an iron-recovery diet. Methods In this study, the morphometrical parameters in the ON were assessed by electron microscopy in Wistar rats that were on an iron-deficient diet for 32 days or for 21 days followed by 10 days on an iron-recovery diet. Qualitative and quantitative analyses were performed using representative electron ultramicrographs. Data were analysed by one-way analysis of variance (ANOVA). When differences were detected, comparisons were made using Tukey's post hoc test (Po0.05 was considered to be significant). Results Qualitative analysis of the ONs in anaemic and recovered animals showed a higher rate of deformed axons and increased lamellar separation in the myelin sheath when compared with the respective control group. The ON of the anaemic group showed a reduced mean density of myelinated fibres when compared with the control group. The fibre area ratio, axon area ratio, and myelin area ratio of large axons/small axons in the ONs of the control group showed the highest values for the myelin areas, axon areas, and total fibre areas. The control group showed a significantly higher myelin sheath thickness when compared with the anaemic and recovered groups. Conclusions Our data indicate that iron is necessary for maintenance of the ON cell structure, and that morphological damage from iron deficiency is not easily reverted by iron repletion.

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Neuritic Outgrowth from Goldfish Retinal Explants, Interaction of Taurine and Zinc

Nusetti

Obregón²,

Lima

Taurine 6

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Optic Nerve Changes in Zinc-deficient Rats

Cited by 28 publications

References 21 publications

Ultrastructure of the Optic Nerve in Magnesium-Deficient Rats

Ultrastructure of the Optic Nerve in Magnesium-Deficient Rats

Effectiveness of iron repletion in the diet for the optic nerve development of anaemic rats

Neuritic Outgrowth from Goldfish Retinal Explants, Interaction of Taurine and Zinc

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