Optic nerve disease and injury: Prospects for induction of regeneration

Schwartz, Michal; Hirschberg, David L.; Yoles, Eti; Solomon, Arieh S.; Belkin, Michael; Eitan, Shoshana; Lavie, Vered; Faber-Elman, A; Beserman, Pierre; Spiegler, Orly

doi:10.1016/1350-9462(96)00013-4

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Η αστρογλοία παρέχει αφ ενός υπόστρωμα για την επιμήκυνση των νευραξόνων (Privat. 2003;Iseda et al, 2004) αλλά αφ ετέρου έχει προταθεί να αναστέλλει τον εκβλάστηση νέων αξόνων (Schwartz et al 1996) ενώ αντίστοιχη δράση εμφανίζεται να έχει και η γλοία του Muller (Reichenbach et al 1993 (Bodeutsch et al, 1999) καθώς επίσης και αμφίπλευρος πολλαπλασιασμός των γλοιακών κυττάρων έχει αποδειχθεί στην μελέτη αυτή (Panagis et al, 2005).…”

Section: οξείες αντιδράσειςunclassified

Bilateral degenerative mechanisms in rat retina following unilateral experimental manipulation of the optic nerve

Panagis¹

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Section: οξείες αντιδράσειςunclassified

Bilateral degenerative mechanisms in rat retina following unilateral experimental manipulation of the optic nerve

Panagis¹

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Degeneration of Spared Axons Following Partial White Matter Lesion: Implications for Optic Nerve Neuropathies

Yoles

Schwartz

1998

Experimental Neurology

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133

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Unilateral optic nerve crush induces bilateral retinal glial cell proliferation

Panagis

Thanos

Fischer

et al. 2005

Eur J of Neuroscience

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The post-injury responses of retinal ganglion cells elicit a number of glial reactions which have not been completely understood. The bilateral pattern of non-neuronal retinal cell proliferation was examined in association with the differential fates of unilaterally injured adult retinal ganglion cells by means of bromodeoxyuridine (BrdU) immunocytochemistry. Lateralization of the glioproliferative events was studied by analysing both the experimental and the uninjured contralateral as well as matched retinas of sham-operated animals. Control adult rat retina included very few BrdU-positive cells within the nerve fibre and ganglion cell layers; however, experimental retinas of degenerating groups exhibited statistically significantly higher densities of newborn cells in most layers. Clusters of labelled cells were found in the inner plexiform layer related to OX-42 staining, indicating their microglial nature. Indeed, double-labelling experiments, after short-term unilateral optic nerve crushing, identified proliferating retinal glial cells in vivo. Both types of glia, astroglial and microglial cells, exhibited BrdU-positive labelling in injured as well as uninjured experimental rat retinas. Moreover, microglial proliferating cells were also identified in explanted retinal pieces after 2 days in culture. Affected and contralateral retinas responded similarly to the unilateral experimental manipulations applied with respect to BrdU labelling. The acute glial responses observed suggest that bilateral glial proliferation might represent a common response related to degeneration events in both retinas, i.e. ipsi- and contralateral to the experimental injury.

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Optic nerve disease and injury: Prospects for induction of regeneration

Cited by 3 publications

References 58 publications

Bilateral degenerative mechanisms in rat retina following unilateral experimental manipulation of the optic nerve

Bilateral degenerative mechanisms in rat retina following unilateral experimental manipulation of the optic nerve

Degeneration of Spared Axons Following Partial White Matter Lesion: Implications for Optic Nerve Neuropathies

Unilateral optic nerve crush induces bilateral retinal glial cell proliferation

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