Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma.

Hamard, P.; Hamard, H; Dufaux, J.; Quesnot, S

doi:10.1136/bjo.78.6.449

Cited by 131 publications

(80 citation statements)

References 13 publications

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“…From a series of experimental studies, Hayreh deduced that GON might be attributable to vascular insufficiency in the optic disc and retrolaminar part of the nerve (Hayreh et al 1970). Clinical studies with fluorescein angiography and laser Doppler velocimetry have shown slow retinal circulation, delayed choroidal filling and reduced optic disc blood velocity in patients with primary open angle glaucoma (POAG) and normal-tension glaucoma (NTG) (Duijm et al 1997;Hamard et al 1994;Schwartz 1994;Wolf et al 1993). However, non-invasive assessment of retrobulbar circulation was difficult, if not impossible, until the development of the color Doppler imaging (CDI) device.…”

mentioning

confidence: 99%

Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the retrobulbar hemodynamics in glaucoma patients with different degrees of optic nerve damage. Methods: Color Doppler imaging was performed in 52 patients with controlled primary open angle glaucoma (POAG) and in 25 control subjects. Glaucomatous eyes were divided into early and late groups based on the perimetry findings. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index of the central retinal artery (CRA) and posterior ciliary arteries (PCA) were evaluated. Results: Early glaucoma showed significantly decreased PSV in nasal PCA when compared with the normal. Late glaucoma showed significantly decreased PSV and EDV in the CRA and nasal PCA, and significantly decreased PSV in temporal PCA as compared with the control and early glaucoma. The resistive index of the CRA also increased significantly in late glaucoma. Conclusion: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in retrobulbar circulation than eyes with less nerve damage.

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confidence: 99%

Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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“…Although optic disc blood velocity was significantly reduced in optic atrophy [25], the calculated flow per unit volume was considered unchanged both in optic atrophy and glaucoma [26,27]. In POAG and NPG, coexistence of a decreased blood velocity in the optic nerve head and an increased blood viscosity has been found [28,29].…”

Section: Introductionmentioning

confidence: 99%

Scanning laser Doppler flowmetry in glaucoma

1996

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Scanning laser Doppler flowmetry is a new means for the measurement of capillary perfusion. We studied the retinal and neuroretinal rim capillary perfusion with the Heidelberg Retina Flowmeter in one randomly selected eye of 31 healthy volunteers, 42 primary open angle glaucoma (POAG) patients and 17 normal pressure glaucoma (NPG) patients. The reproducibility of the measurements on the temporal and nasal retina and on the disc rim was 19%, 26% and 28% in the unselected control group, 12% in the POAG and 12%, 13% and 10% in the NPG group, respectively. Optic disc flow was significantly higher than retinal flow (p < 0.000001). Differences in corresponding flow values between healthy volunteers and glaucoma patients as well as between POAG and NPG patients were not statistically significant. There was no correlation between the temporal and nasal flow values of the same eyes. The average variation in flow between adjacent frame positions was 18.5%. Actual intraocular pressure and the type of treatment had no influence on the retinal flow. The results suggest that the position of the test-frame is very important for the final result. We could not find any significant difference in the perfusion between glaucomatous and control eyes with the Heidelberg Retina Flowmeter.

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“…In addition to perfusion pressure and local vascular resistance, blood viscosity can also reduce OBF (Flammer, 2002). Glaucoma patients have been described as having decreased erythrocyte deformability (Ates, 1998), hyperaggregability of the erythrocytes (Hamard, 1994) and altered red blood cell membrane integrity (Carter, 1990). In addition, the presence of an activated coagulation cascade (O'Brien, 1997) and an increase in platelet aggregability (Hoyng, 1992) (Bojic, 1998) have been reported in glaucoma patients.…”

Section: Altered Blood Flow As a Risk Factor For Glaucoma (Progression)mentioning

confidence: 99%