Optic Neuritis as an Isolated Presentation of Kikuchi–Fujimoto Disease in a Pediatric Patient

Abstract

To the Editor, Kikuchi-Fujimoto disease (KFD), which is also known as histiocytic necrotizing lymphadenitis, is a rare, idiopathic, and benign disease.

Optic Neuritis in a Pediatric Patient with Kikuchi–Fujimoto Disease: A Case Report and Review of the Literature

“… 7 KFD is rarely reported with ocular manifestations, including uveitis, retinal vein, optic neuritis, lacrimal gland involvement, oculomotor palsy, and etc. 4 Our case of a 13-year-old male patient with the KFD and the bilateral optic neuritis illustrates the possibility of considering this association.…”

Kikuchi-Fujimoto disease: State of the art

“…There are individual reports of familiar occurrence of KFD. 3,5,9 Autoimmune diseases, e.g., Still's disease, SLE, Hashimoto's disease, granulomatosis with vasculitis, are reported to co-occur with KFD. In most cases, Hashimoto's disease manifested itself at the same time as KFD.…”

“…5,6,12 Individual cases of patients in whom KFD was manifested by optic neuritis were also reported in the literature. 9 In most cases, the course of the disease is mild. However, some patients develop severe symptoms associated with hemophagocytic lymphohistiocytosis (HLH).…”

“…In cases where the disease has not resolved spontaneously, a symptomatic treatment should be offered. 2,3,5,9 Non-steroidal anti-inflammatory and analgesic drugs should use in pharmacological treatment. Glucocorticosteroids are used in severe cases, but the exact dose and duration of treatment should be individually-tailored.…”

“…3 In cases KFD extending from optic neuritis, glucocorticoids and rituximab was used with good therapeutic effect. 9 It has shown that antibiotic therapy KFD is ineffective. However, they are often used to avoid the potential superinfection lymph node.…”