Optic Neuritis Complicating Measles, Mumps, and Rubella Vaccination

Kazarian, Edward L.; Gager, W E

doi:10.1016/0002-9394(78)90304-5

Cited by 57 publications

(13 citation statements)

References 27 publications

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“…Six months later she developed a left O N from which she also recovered completely. Isolated ON has been reported in a child 11 days after MMR immunization [41]. Eight months after the attack of ON the girl developed a second but milder attack of transverse myelitis one week after being exposed to natural rubella.…”

Section: Measlesmentioning

confidence: 96%

Neurological complications of immunization

Fenichel

1982

Annals of Neurology

142

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Vaccines prepared from whole, killed organisms (pertussis and possibly influenza) may cause neurological allergic reactions producing encephalopathy. These reactions are characterized by acute, monophasic demyelinative processes and occur with no greater frequency than 1 per 100,000 vaccine recipients; onset is within 4 days of immunization, and recovery is usually complete. No evidence suggests that these vaccines produce an insidious, progressive encephalopathy. Only with the swine influenza program of 1976 has Guillain-Barré syndrome appeared to follow immunization. Vaccines prepared from live-attenuated viruses (measles, mumps, rubella, and trivalent oral poliovirus) can cause symptomatic viral infection of the nervous system, including measles encephalitis, which occurs in 1 of 1,000,000 vaccine recipients; rubella neuritis, in less than 1 of 10,000 recipients; and paralytic poliomyelitis, in 1 of 3,000,000 vaccine recipients or their close contacts. A cause-and-effect relationship between immunization and brachial plexus neuritis, acute transverse myelitis, and cranial neuropathies has been suggested but never proved.

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Section: Measlesmentioning

confidence: 96%

Neurological complications of immunization

Fenichel

1982

Annals of Neurology

142

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“…Immunization against rubella was associated with diffuse myelitis and recurrent relapses with optic neuritis, paraparesis and impaired motor function (39, 40). Transverse myelitis (41) as well as optic neuritis (42, 43) were reported in patients vaccinated against measles, mumps and rubella. Further cases with symptoms suggestive for disseminated encephalitis were reported after vaccination against diphtheria-tetanus-poliomyelitis (DTP) (44) and after immunization against smallpox, rabies or typhus (45).…”

Section: Basic Immunology Of Vaccinationmentioning

confidence: 99%

Vaccination in Multiple Sclerosis: Friend or Foe?

et al. 2019

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Multiple sclerosis (MS) is a debilitating disease of the central nervous systems (CNS). Disease-modifying treatments (including immunosuppressive treatments) have shown positive effects on the disease course, but are associated with systemic consequences on the immune system and may increase the risk of infections and alter vaccine efficiency. Therefore, vaccination of MS patients is of major interest. Over the last years, vaccine hesitancy has steadily grown especially in Western countries, partly due to fear of sequelae arising from vaccination, especially neurological disorders. The interaction of vaccination and MS has been discussed for decades. In this review, we highlight the immunology of vaccination, provide a review of literature and discuss the clinical consideration of MS, vaccination and immunosuppression. In conclusion, there is consensus that MS cannot be caused by vaccines, neither by inactivated nor by live vaccines. However, particular attention should be paid to two aspects: First, in immunocompromised patients, live vaccines may lead to a stronger immune reaction with signs of the disease against which the patients have been vaccinated, albeit in weakened form. Second, protection provided by vaccination should be controlled in patients who have been vaccinated while receiving immunomodulatory or immunosuppressive treatment. In conclusion, there is evidence that systemic infections can worsen MS, thus vaccination will lower the risk of relapses by reducing the risk of infections. Therefore, vaccination should be in general recommended to MS patients.

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“…26,31 Specific infectious diseases that have been associated with pediatric ON include measles, mumps, 26,31,63 chickenpox, 64 rubella, brucella, pertussis, mononucleosis, and Epstein-Barr virus. 64 Specific vaccines that have been associated with pediatric ON include, diphtheria-pertusis-tetanus, 67 measles-mumps-rubella, 68 Bacille Calmette-Guérin, 69 hepatitis B, 70 and influenza H1N1. 64 Specific vaccines that have been associated with pediatric ON include, diphtheria-pertusis-tetanus, 67 measles-mumps-rubella, 68 Bacille Calmette-Guérin, 69 hepatitis B, 70 and influenza H1N1.…”

Section: Postinfectious/postvaccinationmentioning

confidence: 99%