Optic Neuritis in a Child With COVID-19: A Rare Association

Parvez, Yusuf; AlZarooni, Fatma; Khan, Farheen

doi:10.7759/cureus.14094

Cited by 17 publications

(15 citation statements)

References 11 publications

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“…In a systematic review of case reports, AMAN was the least reported variant of GBS, occurring in 8 out of 77 cases [ 30 ]. To date, there are only two reports of pediatric optic neuritis associated with COVID-19, one occurring during active infection and one as the presenting symptom of MIS-C in a PCR-negative, seropositive child [ 32 , 33 ]. Patient 13 presented with acute vision impairment and neurophysiologic evidence of optic nerve demyelination in the face of a negative PCR and positive IgG.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia

Putri

Prawira

Tartila

et al. 2022

Journal of Tropical Pediatrics

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Background While the number of cases of multisystem inflammatory syndrome in children (MIS-C) is increasing, reported cases in Asian countries are still low, particularly in Indonesia. This study aimed to describe the characteristics of patients with MIS-C in a tertiary referral hospital in Indonesia. Methods This is a cross-sectional study with collected data of patients with MIS-C admitted to Dr. Cipto Mangunkusumo from March 2020 to April 2021. Results The first case of MIS-C was detected 5 months after the first reported coronavirus disease 2019 case in Indonesia. Thirteen patients out of 158 positive admitted patients for COVID-19 were diagnosed with MIS-C during the study period. Of these 13 patients, 2 patients (15%) had a fatal outcome. Subjects were predominantly male, and the median age was 7.58 years (IQR 12.3) years. Most patients required mechanical ventilation (7 out of 13 patients) and intubation (8 out of 13 patients). Patients who needed intubation usually needed mechanical ventilation. All inflammatory markers, white blood cells, neutrophil counts, and all coagulation factor parameters (except for normal prothrombin time and activated partial prothrombin time) were elevated. The median time to MIS-C diagnosis was 2 days in the survivor group (n = 11) compared to 8.5 days in the non-survivor group (n = 2). Compared to the non-survivor group, those who survived spent more days in the hospital, received vasopressors earlier, and did not require mechanical ventilation as early as the non-survivors. Conclusions Our work highlights the differences in MIS-C clinical course, treatment, and clinical outcomes between the two groups.

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Section: Discussionmentioning

confidence: 99%

Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia

Putri

Prawira

Tartila

et al. 2022

Journal of Tropical Pediatrics

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“…Vasculitis may accompany intracranial infections and up to one-third of children with stroke have postvaricella angiopathy occurring weeks to months after uncomplicated chickenpox [ 94 ]. Vasculitis and associated infarction are frequent reported in children with COVID-19 infection [ 10 , 20 , 21 , [41] , [42] , [43] , [44] , [45] , [46] , [47] ].…”

Section: Mr Neuroimagingmentioning

confidence: 99%

“…[ 10 ]. Numerous case reports have indicated the presence of acute encephalopathy or encephalitis [ [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ], acute necrotizing encephalopathy (ANE) [ 25 , 26 ], acute disseminated encephalomyelitis (ADEM) [ 20 , [26] , [27] , [28] , [29] , [30] , [31] , [32] ], cytotoxic lesions in the callosal splenium [ 26 , [33] , [34] , [35] , [36] , [37] ], posterior reversible encephalopathy syndrome (PRES) [ 26 , 38 ], cerebral venous thrombosis [ 39 , 40 ], vasculitis and acute infarction [ 20 , 21 , [41] , [42] , [43] , [44] , [45] , [46] , [47] ], Guillain–Barré syndrome (GBS) [ 20 , 21 , 26 , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] ] and its variant Miller-Fisher syndrome (MFS) [ [59] , [60] , [61] , [62] ], transverse myelitis [ 9 , 50 ,…”

Section: Introductionmentioning

confidence: 99%

Spectrum of neuroimaging mimics in children with COVID-19 infection

Wong

Toh

2022

Biomedical Journal

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“…The diagnosis of left optic neuritis was then confirmed by the orbit's MRI, which showed moderate enlargement and minor T2 hyperintensity of the left optic nerve's intracanalicular and intraorbital segments. 50 …”

Section: Complications In Paediatric Populationmentioning

confidence: 99%

An overview of the COVID‐19 complications in paediatric population: A pandemic dilemma

2021

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Aim The primary objective of this article is to understand the various complications caused by the coronavirus in the paediatric population. Method An electronic search was conducted using PubMed and incorporated forward and backward research methods on clinical trials, case reports, case series, guidelines and reports from the centre for disease control and prevention (CDC), and the keywords included COVID‐19, paediatrics, multisystem inflammatory syndrome in children (MIS‐C), complications, acute kidney injury and heart failure. Secondary resources included one study from preprint servers (http://www.preprints.org), last search 8 May 2021, with notion of nonpeer review status. Data were collected and analysed to stay current with the most recent alerts and guidelines for the best care for children during the COVID‐19 pandemic. Results Evaluation and analysis of literature revealed MIS‐C to be the most prevalent followed by neurological complications. Whereas the least prevalent were septic shock and ophthalmic complications. Conclusion Even though COVID‐19 is known to be a less severe in the paediatric population, the complications of the virus have caused a great deal of stress to the paediatric patients’ parents and paediatricians worldwide, and hence, emphasis should be given to the management of coronavirus complications in paediatrics.

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Optic Neuritis in a Child With COVID-19: A Rare Association

Cited by 17 publications

References 11 publications

Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia

Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia

Spectrum of neuroimaging mimics in children with COVID-19 infection

An overview of the COVID‐19 complications in paediatric population: A pandemic dilemma

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