Leukocytosis is well recognised in neonate; mostly it is physiological but the counts rarely exceed 30,000/mm 3 . Hyperleukocytosis defined as WBC count of more than 100,000 mm 3 is rare and imposes a diagnostic challenge and should be investigated for leukaemia, leukocyte adhesion defect and myeloproliferative disorders. We report a classic case to highlight this entity.

The recent coronavirus disease-2019 (COVID-19) pandemic has caused significant mortality and morbidity, affecting patients of all ages. COVID-19 affects various tissues and systems in the body, including the central and peripheral nervous systems. However, COVID-19 has rarely affected the eyes and caused optic neuritis. We report a unique case of COVID-19-related unilateral optic neuritis in a 10-year-old girl.

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Epstein Barr virus (EBV) encephalitis is rare in children but can have severe neurological complications and sometimes fatal. It can manifest with varied neurological presentations like meningoencephalitis, brain stem encephalitis, GBS etc. This can appear alone or with clinical picture of infectious mononucleosis. Establishing a diagnosis of EBV encephalitis is difficult and consequently molecular, serological and imaging techniques should be used when investigating a child with encephalitis. To highlight this entity we report two fatal cases of EBV meningoencephalitis presenting with sole neurological manifestations.

Apparent mineralocorticoid excess (AME) syndrome is a rare autosomal recessive disorder due to the deficiency of 11b hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2). Mutations in this gene affect the enzymatic activity resulting to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor leading to inherited hypertension.This is a potentially fatal but treatable disorder. We present clinical and molecular studies on two sisters diagnosed as AME.