Optic Neuropathy and Central Retinal Artery Occlusion in Non-Hodgkin Lymphoma

Fierz, Anna; Sartoretti, Sabine; Thoelen, Adelheid M.

doi:10.1097/00041327-200106000-00009

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…LON was difficult to diagnose as his MRI and LP were initially normal. Negative MRI and LP in LON are not uncommon [4,5]. As in our patient, LON may only appear as enhancement of the optic nerve on MRI and could be easily confused with optic neuritis [5].…”

Section: Discussionsupporting

confidence: 51%

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Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Wong

Danesh‐Meyer

Pon

2015

Journal of Clinical Neuroscience

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Section: Discussionsupporting

confidence: 51%

“…Isolated LON without other CNS involvement or systemic disease has been reported in the literature and can be either unilateral or bilateral [1][2][3][4][5]. Visual loss is usually severe and is frequently associated with disc swelling, peripapillary haemorrhage and RAPD.…”

Section: Discussionmentioning

confidence: 99%

Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Wong

Danesh‐Meyer

Pon

2015

Journal of Clinical Neuroscience

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“…As diffusion restrictions of the optic nerve were only infrequently present in our collective of CRAO patients (sensitivity 25-55%) and unweighted kappa indicated only fair IRR, its diagnostic utility for diagnosis of CRAO seems limited. So far, only a few cases of diffusion restrictions of the optic nerve in CRAO have been reported in the literature [24,25]. Bender et al evaluated DWI in patients with acute loss of vision, including five patients with ischemic optic neuropathy (ION) [23].…”

Section: Discussionmentioning

confidence: 99%

“…Acute ischemic lesions are found in approximately 25% of CRAO patients [19,21,22]. Reports of diffusion-weighted imaging (DWI)-related abnormalities of the optic nerve in CRAO, however, have been limited to a few cases [23][24][25]. To the best of our knowledge, no systematic MRI studies related to distinctive retinal features in CRAO have been published [26,27].…”

Section: Introductionmentioning

confidence: 99%

Standard Diffusion-weighted MRI for the Diagnosis of Central Retinal Artery Occlusion

et al. 2020

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Purpose To evaluate diffusion abnormalities of the retina and optic nerve in patients with central retinal artery occlusion (CRAO) using standard stroke diffusion-weighted magnetic resonance imaging (DWI). Methods In this case-control study, DWI scans of patients with nonarteritic CRAO were retrospectively assessed for acute ischemia of the retina and optic nerve. Two neuroradiologists, blinded for patient diagnosis, randomly evaluated DWI of CRAO patients and controls (a collective of stroke and transient ischemic attack [TIA] patients) for restrictions of the retina and optic nerve. We calculated statistical quality criteria and analyzed inter-rater reliability using unweighted Kappa statistics. Results 20 CRAO patients (60,6 ± 17 years) and 20 controls (60,7 ± 17 years) were included in the study. Sensitivity, specificity, positive and negative predictive values for retinal DWI restrictions were 75%/80%/79%/76% (reader 1) and 75%/100%/100%/80% (reader 2), respectively. Unweighted Kappa was κ = 0,70 (95% CI 0,48‑0,92), indicating “substantial” interrater reliability. In comparison, sensitivity, specificity, PPV and NPV (positive and negative predictive values) for restrictions of the optic nerve in CRAO were 55%/70%/65%/61% (reader 1) and 25%/100%/100%/57% (reader 2). Inter-rater reliability was “fair” with unweighted Kappa κ = 0,32 (95% CI 0,09‑0,56). Conclusions Retinal diffusion restrictions were present in a majority of CRAO patients and detectable with reasonable sensitivity, high specificity and substantial inter-rater reliability. Further studies are necessary to study time dependency of retinal diffusion restrictions, improve image quality and investigate the reliability of retinal DWI to discern CRAO from other causes of acute loss of vision.

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“…Central retinal vessel oclusion is a very rare event in systemic lymphomas. Cases with optic nerve involvement with CRAO reported in the literature [12,13]. Retinal artery occlusion may be caused or facilitated by: a) compression of the retinal artery by lymphomatous infiltration of optic nerve, b) direct periarterial tumor infiltration, c) Paraneoplastic hypercoagulability and d) septic emboli in patients with sepsis [14].…”

Section: Casementioning

confidence: 99%

Neuroophthalmological Manifestations of Systemic Lymphomas

Soysal

Gökmen

2018

MSOR

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Background:We aimed to present neuroophthalmological manifestations that seen in patients with systemic lymphoma.Methods: All patients with systemic lymphoma that consulted due to ophthalmologic problems were evaluated for neuroophthalmological abnormalities. Clinical findings were recorded if any abnormality was detected.Results: Several neuroophthalmological manifestations were founded in 16 patients. Symptoms were; ptosis, pain, diplopia and visual loss. Signs were; ophthalmoplegia, pupillary abnormalities, ptosis, visual loss, and swollen optic disc. Involvement of optic nerve (4 cases), abducens nerve (5 cases), oculomotor nerve (3 cases) and multiple cranial nerves (7 cases) was detected. In 8 cases, positive cerebro spinal fluid citology or radiodiagnostic findings were present to consider central nervous system (CNS) involvement, while in 8 cases these findings were normal. Overt CNS involvement was occurred later in additional 3 cases. Conclusion:Systemic lymphomas can cause neuroophthalmological manifestations during disease or, as a presenting sign of primary or recurrent lymphoma. These manifestations are usually precursors of central nervous system involvement. Early detection is important for reversal of symptoms, but the prognosis is usually not favorable.

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Optic Neuropathy and Central Retinal Artery Occlusion in Non-Hodgkin Lymphoma

Cited by 7 publications

References 5 publications

Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Standard Diffusion-weighted MRI for the Diagnosis of Central Retinal Artery Occlusion

Neuroophthalmological Manifestations of Systemic Lymphomas

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