2013
DOI: 10.1007/s10103-013-1268-7
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Optical and spectroscopic properties of human whole blood and plasma with and without Y2O3 and Nd3+:Y2O3 nanoparticles

Abstract: The optical properties of human whole blood and blood plasma with and without Y2O3 and Nd3+:Y2O3 nanoparticles are characterized in the near infrared region at 808 nm using a double integrating sphere technique. Using experimentally measured quantities of diffuse reflectance and diffuse transmittance, a computational analysis was conducted utilizing the Kubelka-Munk, the Inverse Adding Doubling, and Magic Light Kubelka-Munk and Monte Carlo Methods to determine optical properties of the absorption and scatterin… Show more

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Cited by 14 publications
(7 citation statements)
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“…The cells started oxygenated, the downward sloping line is the absorbance at 500 nm as the oxygen decreases, and the flat line at the bottom tells us that all of the H b O 2 has released its oxygen. The similar effect of Y 2 O 3 and Nd 3 + :Y 2 O 3 nanoparticle on human whole blood is reported by Frederick et al 36…”
Section: Resultssupporting
confidence: 86%
“…The cells started oxygenated, the downward sloping line is the absorbance at 500 nm as the oxygen decreases, and the flat line at the bottom tells us that all of the H b O 2 has released its oxygen. The similar effect of Y 2 O 3 and Nd 3 + :Y 2 O 3 nanoparticle on human whole blood is reported by Frederick et al 36…”
Section: Resultssupporting
confidence: 86%
“…In these hosts, however, the Nd 3+ emissions from the Stark components of a given energy level manifold are generally poorly resolved relatively to the corresponding spectral emissions in other inorganic hosts, such as cubic Y2O3 and Gd2O3 26,[30][31][32][33] and yttrium aluminium garnet (YAG). 34 Comparatively, the Nd 3+ NIR emission lines of the latter hosts are much better resolved even in the biological media and ex-vivo experiments (e.g., in human whole blood 35 and chicken breast 34 ). Nevertheless, the Nd 3+ host oxides have been barely employed for in vitro/in vivo thermal sensing and bioimaging applications.…”
Section: Introductionmentioning
confidence: 99%
“…Whole blood has absorption maxima at 545 and 578 nm, as has been previously reported in the literature. 26 Thus, the presence of blood significantly hinders fluorescence imaging of any residual tumor cells. Wide-field visualization of 5-ALA-induced protoporphyrin IX contrast is effective at revealing regions of bulk tumor (deep red), but fluorescence intensities decay near the margins (lighter pink) and vanish entirely as the tumor cell density continues to decline.…”
Section: Resultsmentioning
confidence: 99%