Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells

Maier, Christoph M.; Huergo, María Ana Cristina; Milosevic, Sara; Pernpeintner, Carla; Li, Miao; Singh, Dhruv; Walker, Debora; Fischer, Peer; Feldmann, Jochen; Lohmüller, Theobald

doi:10.1021/acs.nanolett.8b03885

Cited by 65 publications

(61 citation statements)

References 52 publications

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“…Herein, our technique can precisely deliver the metal-coated Janus particle to the target via two working modes at a low operation power. Thus, opto-thermoelectric microswimmers are promising for carrying drug molecules on non-metallic parts and precisely delivering them to target cells 58 .…”

Section: Resultsmentioning

confidence: 99%

Opto-thermoelectric microswimmers

et al. 2020

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Inspired by the “run-and-tumble” behaviours of Escherichia coli ( E. coli ) cells, we develop opto-thermoelectric microswimmers. The microswimmers are based on dielectric-Au Janus particles driven by a self-sustained electrical field that arises from the asymmetric optothermal response of the particles. Upon illumination by a defocused laser beam, the Janus particles exhibit an optically generated temperature gradient along the particle surfaces, leading to an opto-thermoelectrical field that propels the particles. We further discover that the swimming direction is determined by the particle orientation. To enable navigation of the swimmers, we propose a new optomechanical approach to drive the in-plane rotation of Janus particles under a temperature-gradient-induced electrical field using a focused laser beam. Timing the rotation laser beam allows us to position the particles at any desired orientation and thus to actively control the swimming direction with high efficiency. By incorporating dark-field optical imaging and a feedback control algorithm, we achieve automated propelling and navigation of the microswimmers. Our opto-thermoelectric microswimmers could find applications in the study of opto-thermoelectrical coupling in dynamic colloidal systems, active matter, biomedical sensing, and targeted drug delivery.

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Section: Resultsmentioning

confidence: 99%

Opto-thermoelectric microswimmers

et al. 2020

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“…Size-selective optical printing of silicon nanoparticles based on their dipolar magnetic resonances was demonstrated as a very efficient way for surface patterning in liquids [155], which represents a prerequisite for the fabrication of all-dielectric metamaterials or metasurfaces [156][157][158]. Optically guided plasmonic Janus nanoparticles were positioned on the surface of a cell and, subsequently, injected into the cell by the combined effect of plasmonic heating and optical forces exerted by a focused illumination beam [159,160]. Multiplying the number of guiding laser beams using a spatial light modulator (SLM) enabled the implementation of optical force stamping lithography, which provided a faster and more flexible deposition of complex nanoparticle patterns [161] (see Fig.…”

Section: Gaussian Beamsmentioning

confidence: 99%

Perspective on light-induced transport of particles: from optical forces to phoretic motion

et al. 2019

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Propulsive effects of light, which often remain unnoticed in our daily-life experience, manifest themselves on spatial scales ranging from subatomic to astronomical. Light-mediated forces can indeed confine individual atoms, cooling their effective temperature very close to absolute zero, as well as contribute to cosmological phenomena such as the formation of stellar planetary systems. In this review, we focus on the transport processes that light can initiate on small spatial scales. In particular, we discuss in depth various light-induced mechanisms for the controlled transport of microscopic particles; these mechanisms rely on the direct transfer of momentum between the particles and the incident light waves, on the combination of optical forces with external forces of other nature, and on light-triggered phoretic motion. After a concise theoretical overview of the physical origins of optical forces, we describe how these forces can be harnessed to guide particles either in continuous bulk media or in the proximity of a constraining interface under various configurations of the illuminating light beams (radiative, evanescent, or plasmonics fields). Subsequently, we introduce particle transport techniques that complement optical forces with counteracting forces of non-optical nature. We finally discuss particle actuation schemes where light acts as a fine knob to trigger and/or modulate phoretic motion in spatial gradients of non-optical (e.g., electric, chemical, or temperature) fields. We conclude by outlining possible future fundamental and applied directions for research in light-induced particle transport. We believe that this comprehensive review can inspire diverse, interdisciplinary scientific communities to devise novel, unorthodox ways of assembling and manipulating materials with light.

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“…6b). 135 The plasmonically heated Au part allows the whole body of the nanopen to penetrate through the complex membrane and their handle-like body delivers the ssDNA while retaining over 75% cell viability. Thus, such enhanced targeted delivery systems should facilitate the practical usage of the hybrid Au NPs in medicine in the near future.…”

Section: Plasmonic Therapymentioning

confidence: 99%

“…(a) Distribution of free Au NRs and neural stem cell (NSC)-aided Au NRs after 3 days of intratumoral injection 131. (b) Positioning and injection of functionalised plasmonic JNPs into cells 135. Left panel shows the SEM micrograph of a JNP consisting of a spherical Au NP (B80 nm) connected to a dielectric alumina shaft (length: B500 nm).…”

mentioning

confidence: 99%