2018
DOI: 10.3390/ma11040526
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Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

Abstract: A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excell… Show more

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Cited by 117 publications
(82 citation statements)
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“…Indeed, radiated fields with momentum close to the BIC point have a polarization winding in a vortex structure around the BIC core, as also recently experimentally verified [13,14]. A striking feature is that the electromagnetic field of a BIC is characterized by a diverging lifetime, or an infinite radiative Q-factor [3,12], from which light-matter interaction could be highly enhanced [16][17][18][19]. Reciprocity implies that far-field excitation of an ideal (infinite Q-factor) BIC mode is not possible.…”
Section: Introductionmentioning
confidence: 73%
“…Indeed, radiated fields with momentum close to the BIC point have a polarization winding in a vortex structure around the BIC core, as also recently experimentally verified [13,14]. A striking feature is that the electromagnetic field of a BIC is characterized by a diverging lifetime, or an infinite radiative Q-factor [3,12], from which light-matter interaction could be highly enhanced [16][17][18][19]. Reciprocity implies that far-field excitation of an ideal (infinite Q-factor) BIC mode is not possible.…”
Section: Introductionmentioning
confidence: 73%
“…uorescence-based enzyme-linked immunosorbent assay (ELISA), which typically achieves sensitivities of the 3-5 pg/mL [36], yet our label-free and very simple approach is more suited for point-of-care applications. It also represents an improvement by over two orders of magnitude compared to plasmonic nanohole array [16] and is even better than a sandwich assay using metal nanoparticles based on a similar structure [37,38] or based on other dielectric metasurfaces [9,39]. We explain this improvement of performance with the high surface sensitivity, the high values of Q-factor and SNR, together with a sharp Fano resonance, which facilitates easy tracking of the resonance.…”
Section: Nanohole Array For Biosensing Applicationmentioning
confidence: 86%
“…The discovery of BICs in optics immediately attracted broad attention (see, e.g., Refs. [4][5][6]) due to high potential in applications in communications [7,8], lasing [9][10][11][12], filtering [13], and sensing [14][15][16]. Recent achievements in the field of BIC are discussed in Refs.…”
Section: Introductionmentioning
confidence: 99%