Optical Coherence Tomography

Altaweel, Michael M.; Johnson, D. L.

doi:10.1016/b978-1-4160-0016-7.50133-8

Cited by 2 publications

(1 citation statement)

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“…8, 9, 10 The parameters required for high quality scans included proper centration of the scan, proper determination of RPE and ILM boundaries by automated algorithm, signal strength of 5 or greater and standard deviation of the center point and center subfield measurements of less than 10%. 11 An eye was defined as having macular edema (ME) if the retinal thickness at the central subfield was 260 μm or greater (normative values 212 ± 20 μm). 8 …”

Section: Methodsmentioning

confidence: 99%

Identifying a Clinically Meaningful Threshold for Change in Uveitic Macular Edema Evaluated by Optical Coherence Tomography

Sugar¹,

Jabs²,

Altaweel³

et al. 2011

American Journal of Ophthalmology

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Purpose To identify a clinically meaningful threshold for change in retinal thickness measured by optical coherence tomography (OCT) for patients with uveitic macular edema, using correlation with change in visual acuity. Design Cross-sectional and longitudinal study. Methods 128 eyes (101 individuals) with macular edema enrolled in the Multicenter Uveitis Steroid Treatment (MUST) trial. At enrollment and after six months of follow-up, retinal thickness was measured at the central subfield with time domain OCT and visual acuity was measured with logarithmic (ETDRS) visual acuity charts. Participants were classified as having macular edema if the retinal thickness was ≥260μm. Results A threshold for change in retinal center subfield thickness of 20% balanced the percentage of false positives and negatives for predicting greater than 10-letter change in visual acuity with sensitivity of 77% and a specificity of 75%. The results were similar for greater than 5 or 15 or greater letter changes. Those with a 20% or greater reduction in retinal thickness had a mean 11.0 letter improvement (95% CI: 7.7 to 14.3) as compared to a -0.4 letter change (95% CI: -4.1 to 3.3) in visual acuity for those without a 20% reduction (p < 0.01). Conclusions In addition to being above the level of measurement uncertainty, a 20% change in retinal thickness in patients with macular edema appears to be optimal for clinically important changes in visual acuity and may be considered as an outcome for clinical trials of treatments for uveitic macular edema.

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