Optical Coherence Tomography Angiography Findings in Coats' Disease

Muakkassa, Nora W.; Carlo, Talisa E de; Choudhry, Netan; Duker, Jay S.; Baumal, Caroline R.

doi:10.3928/23258160-20160707-04

Cited by 22 publications

(16 citation statements)

References 11 publications

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“…Although classically unilateral, recent reports in the literature argue for bilateral vascular findings, asymmetric in appearance and of decreased severity in the fellow eye, in a proportion of patients. 5–7 To the best of our knowledge, this is the largest cohort examining the presence of fellow-eye findings in Coats’ patients and is the only study to examine whether these changes evolve over time.…”

Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography angiography has also demonstrated abnormal macular foveal avascular zone in fellow unaffected eyes of patients with unilateral Coats, which also supports that the retinovascular abnormality is not isolated to the unilateral affected eye. 7 This study was a retrospective review of previously taken images, so we suspect that if physicians are purposely looking for these changes, that even more peripheral views and detailed fluorescein angiograms would be obtained, leading to potential detection of even more fellow-eye findings. Therefore, fellow-eye findings may possibly be considerably more prevalent compared to what we found in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Although Coats’ disease was initially considered a unilateral retinovascular disorder, vascular changes have been since been documented in the unaffected (fellow) eyes with various imaging modalities. 5–7 However, little is known regarding the clinical significance of these abnormalities. This study investigates the longitudinal progression of fellow-eye findings using WFA, the presence of any associated factors for these findings, and their implications for Coats’ disease screening and treatment.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study

Jeng-Miller¹,

Soomro²,

Scott³

et al. 2019

Ophthalmic Surg Lasers Imaging Retina

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BACKGROUND AND OBJECTIVE: Retinovascular anomalies in the fellow eyes of patients with Coats’ disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. PATIENTS AND METHODS: This is an international, multi center, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats’ disease. RESULTS: Three hundred fifty eyes of 175 patients with Coats’ disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats’ disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16). CONCLUSIONS: The vascular abnormalities in fellow eyes of patients with Coats’ disease did not progress over time. Observation is a reasonable initial management strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study

Jeng-Miller¹,

Soomro²,

Scott³

et al. 2019

Ophthalmic Surg Lasers Imaging Retina

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“…Prior reports have demonstrated nonperfusion of the superficial capillary plexus with arborizing, rarefied, looped, and/or dilated capillary networks on OCT-A of Coats' disease eyes. 7,11,12 These imaging modalities may provide further insights into the pathophysiology of Coats' disease, and evaluation of their relationship to vision and macular SD-OCT findings could be useful. However, wide-field OCT and OCT-A were not performed in any of the patients in this study.…”

Section: Discussionmentioning

confidence: 99%

Spectral Domain Optical Coherence Tomography Findings in Coats Disease

Gupta

Dow

Jeng-Miller

et al. 2019

Retina

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“…However, to date, there have been limited reports of OCT findings in Coats' disease that describe structural and visual response to therapy. 5 – 12 Most studies have only reported on the presence of cross-sectional abnormal OCT findings including epiretinal membrane, intraretinal cystoid spaces, subretinal fluid (SRF), lipid exudation, retinal scar, subretinal hyperreflective nodule, and macular atrophy. 5 , 8 , 10 – 12 Except for fibrotic nodule, 10 , 11 , 13 these publications did not address the relationship between these OCT morphologies and visual acuity (VA).…”

mentioning

confidence: 99%

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease

Ong

Mruthyunjaya

Stinnett

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PurposeTo investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease.MethodsThirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up ≥ 6 months) and across visits.ResultsMean VA ± standard deviation at baseline (37 eyes) was 0.92 ± 0.82. SD-OCT features associated with worse VA included, for treatment-naïve eyes (n = 21), outer retinal atrophy (ORA) (1.18 ± 0.34 with versus 0.20 ± 0.30 without, P = 0.005), subretinal fluid (SRF) (1.80 ± 0.63 vs. 0.63 ± 0.50, P = 0.008), bright hyperreflectivities (1.23 ± 0.68 vs. 0.52 ± 0.53, P = 0.02), thicker foveal subretinal space (r2 = 0.32, P = 0.01), and CSF (r2 = 0.39, P = 0.007); and for previously treated eyes (n = 16), a compact hyperreflective structure (1.60 ± 0.88 vs. 0.56 ± 0.64, P = 0.02) and ORA (1.34 ± 0.86 vs. 0.30 ± 0.44, P = 0.01). At final follow-up (n = 22), mean VA was 0.81 ± 0.83. Eyes with final VA <20/200 (n = 6, vs. >20/60, n = 11) more commonly had a compact hyperreflective structure and ORA at baseline and final visit (P < 0.05). Mean change in VA from baseline (n = 20) was −0.20 ± 0.59. Mean improvement in VA (range, −0.525 to −1.127) occurred in eyes with baseline SRF (P = 0.02) and bright hyperreflectivities (P = 0.03). Changes in thickness that correlated with change in VA included those for the foveal subretinal space (r2 = 0.52, P < 0.001) and CSF (r2 = 0.26, P = 0.045).ConclusionsA compact hyperreflective structure (fibrosis) and ORA were associated with poor final VA while SRF, bright hyperreflectivities (exudation), and foveal subretinal thickness were associated with VA improvement post treatment.

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Optical Coherence Tomography Angiography Findings in Coats' Disease

Abstract: OCTA may demonstrate an abnormal foveal avascular zone in both the affected eye and the clinically unaffected fellow eye, suggesting widespread pathology of the retinal vasculature in Coats' disease. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:632-635.].

Cited by 22 publications

References 11 publications

Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study

Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study

Spectral Domain Optical Coherence Tomography Findings in Coats Disease

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease

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