Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

Kaizu, Yoshihiro; Nakao, Shintaro; Hayami, Takehito; Arima, Mitsuru; Yamaguchi, Muneo; Wada, Iori; Hisatomi, Toshio; Ikeda, Yasuhiro; Ishibashi, Tatsuro; Sonoda, Koh Hei

doi:10.1167/iovs.17-22306

Cited by 40 publications

(39 citation statements)

References 38 publications

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“…FD-300 represents the vessel density of the full retina around FAZ within a width of 300 μm. FD-300 was significantly decreased in DR compared with that in non-diabetic retinopathy controls and was negatively correlated with the stage of DR [2]. Here our study indicated that FD-300 is also decreased in CRAO and BRAO eyes compared with that in fellow eyes.…”

Section: Discussionsupporting

confidence: 60%

“…Due to its convenience and safety, OCT-A is currently widely used in diagnosing and evaluating various vascular-associated retinal or choroidal diseases, such as diabetic retinopathy, choroidal neovascularization, and retinal vein occlusion [1][2][3]. Although several case reports and studies reported the application of OCT-A in RAO, these publications are sporadic and lack quantitative analysis [4].…”

Section: Introductionmentioning

confidence: 99%

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Optical coherence tomography angiography characteristics of acute retinal arterial occlusion

Yang

Liu

et al. 2019

BMC Ophthalmol

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Background: To characterize the vascular changes in eyes within the acute phase of retinal arterial occlusion (RAO) by optical coherence tomography angiography (OCT-A) imaging. Methods: This was a retrospective, observational study. Nineteen patients with RAO (symptom onset within 7 days) and 19 age and sex-matched normal control individuals were included. A comprehensive ophthalmic examination and OCT-A examination were conducted for all the patients. Results: The vessel density of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and area with a width of 300 μm around the FAZ (FD-300) was significantly reduced in RAO patients compared with that in the fellow eyes and normal control eyes. The vessel density of the SCP of RAO fellow eyes was significantly lower than that of the normal control eyes (all P < 0.05). Though no difference was observed in the FAZ of RAO eyes compared with that of fellow eyes and normal control eyes, the acircularity index (AI) of the FAZ was significantly increased in RAO eyes (P < 0.05). Central macular thickness (CMT) was correlated with best-corrected visual acuity in central retinal arterial occlusion (CRAO) patients (r = 0.626, P = 0.024). In BRAO eyes, the vessel density of the RAO-affected hemifield was significantly reduced compared with that of the unaffected hemifield (P < 0.05). Radial peripapillary plexus (RPC) vessel density was reduced, accompanied by retinal nerve fiber layer (RNFL) thinning in 3 available CRAO patients. Conclusions: As a valuable noninvasive imaging tool, OCT-A provides deeper and more detailed vascular information that extends our understanding of the vasculature alterations in acute RAO.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography characteristics of acute retinal arterial occlusion

Yang

Liu

et al. 2019

BMC Ophthalmol

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“…OCTA has the unique ability to visualize, quantify, and distinguish vascular and structural changes in all retinal and choroidal layers. Until now, OCTA has been used to image and describe many common and relatively rare types of vasculopathies in DR.[ 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 47 48 49 50 51 52 53 54 55 56 57 ] OCTA was comparable to clinical examination and FA to demonstrate vascular changes including microaneurysms (MAs), impaired perfusion, retinal edema, vascular loops, intraretinal microvascular abnormalities (IRMAs), and neovascularization (NVs). [ 40 ]…”

Section: Resultsmentioning

confidence: 90%

“…Unlike previous belief, that DR involves the temporal area more than the nasal area; there is no preference for DR to involve the nasal or temporal area on VD assessment. [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy¹,

Aghdam²,

Falavarjani³

2018

J Ophthalmic Vis Res

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Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for 3-dimensional visualization of retinal and optic nerve capillary networks. In this article, a comprehensive review of relevant original articles in the PubMed database was performed using the search terms “diabetic retinopathy,” “diabetic macular edema,” “diabetes mellitus,” and “optical coherence tomography angiography.” OCTA was found to detect microvascular changes early in diabetes mellitus, even before they become clinically evident. Morphological and qualitative assessment of vascular changes can help to determine the pathophysiological processes, activity, treatment, and follow-up of diabetic retinopathy (DR). Vessel density and foveal avascular zone are the most investigated quantified indices shown to be early predictors of DR, correlated to DR severity and visual function, and useful in predicting response to treatment. OCTA has shown to be a promising alternative to fluorescein angiography in the management of DR. Further studies are warranted to determine the role of OCTA in the routine clinical management of DR.

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“…Some reports have noted that FAZ area in PDR was significantly larger than in healthy subjects. Additionally, they have reported that FAZ and PD are significantly correlated 19. The final contributing factor or explanation is that DR-related microvasculature damage may actually begin around the macula, and thus the 3×3 mm image would be expected to have the best predictive sensitivity for DR. Longitudinal studies using wide-field SS-OCTA images are needed to evaluate this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

et al. 2018

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Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

Cited by 40 publications

References 38 publications

Optical coherence tomography angiography characteristics of acute retinal arterial occlusion

Optical coherence tomography angiography characteristics of acute retinal arterial occlusion

An update on optical coherence tomography angiography in diabetic retinopathy

Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

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