Optical Coherence Tomography Findings in Ocular Syphilis Involving the Posterior Segment of the Eye

Vaze, Anagha; Angelis, Rafael Estevão De; Simões, Milena; Arantes, Tiago Eugênio Faria e; Moreto, Renata; Oliver, Genevieve F.; Smith, Justine R.; Furtado, João M.

doi:10.1080/09273948.2021.1892152

Cited by 12 publications

(4 citation statements)

References 21 publications

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“…OCT is a valuable tool for diagnosing and monitoring ocular syphilis involving the retina and choroid. In a study by Vaze et al, all 54 eyes with syphilitic uveitis involving the posterior segment had at least one retinal finding on OCT [ 14 ]. The findings in the outer retina always involve RPE changes, such as thickening, irregularities, detachment, and hyper-reflective nodular elevations [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Vaze et al, all 54 eyes with syphilitic uveitis involving the posterior segment had at least one retinal finding on OCT [ 14 ]. The findings in the outer retina always involve RPE changes, such as thickening, irregularities, detachment, and hyper-reflective nodular elevations [ 14 ]. RPE and outer retinal lesions caused by syphilis can be reconstituted after antibiotic treatment [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Syphilitic Uveitis With Diverse Clinical Presentations: Multimodal Imaging as a Useful Adjunctive Tool for Diagnosis and Treatment

Kawamoto,

Hiyama,

Sada

et al. 2024

Cureus

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We report four cases of syphilitic uveitis with diverse clinical presentations. All patients were men who have sex with women, and were aged 19-68 years, and none were HIV-positive. All cases were bilateral. One case presented with anterior uveitis, while three exhibited panuveitis. One patient had acute syphilitic posterior placoid chorioretinitis and two had retinal vasculitis resulting in damage to the outer retinal and retinal pigment epithelium. The rapid plasma reagin (RPR) test and Treponema pallidum (TP) hemagglutination test were both positive in all cases. Six of eight eyes had improved vision and best-corrected visual acuity better than 20/20 after antibiotic treatment. Serological testing is mandatory for the diagnosis of syphilitic uveitis. Additionally, multimodal imaging, including optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA), can provide useful adjunctive information for early diagnosis and assessment of treatment response.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Syphilitic Uveitis With Diverse Clinical Presentations: Multimodal Imaging as a Useful Adjunctive Tool for Diagnosis and Treatment

Kawamoto,

Hiyama,

Sada

et al. 2024

Cureus

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“…In addition to multiple roles in retinal homeostasis, including maintenance of the bloodretinal barrier, the retinal pigment epithelium has been identified as a key host cell for a range of micro-organisms, including some bacteria and parasites (e.g., Mycobacteria tuberculosis and Toxoplasma gondii) [38,39], and a host of different viruses including flaviviruses (e.g., DENV, Zika virus [ZIKV], West Nile virus), herpesviruses (e.g., herpes simplex virus, varicella zoster virus, cytomegalovirus), and filoviruses (i.e., Zaire ebolavirus) [40][41][42][43][44][45]. Ophthalmic imaging studies in patients have documented changes implicating the retinal pigment epithelium in other infectious diseases (e.g., syphilis and coronavirus disease 2019) [46,47]. Two prior studies have explored the susceptibility of the human retinal pigment epithelium to infection with DENV, including our previous report [10] and the report by Singh and associates that focused on ZIKV infection [40]; however, both these studies used DENV-2 strains, rather than DENV-1 strains.…”

Section: Discussionmentioning

confidence: 99%

Infection of Human Retinal Pigment Epithelial Cells with Dengue Virus Strains Isolated during Outbreaks in Singapore

et al. 2022

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Prevalence of dengue retinopathy varies across epidemics, with the disease linked to circulation of dengue virus serotype 1 (DENV-1). The retinal pigment epithelium has been implicated in the pathology. We investigated infectivity, molecular response, and barrier function of epithelial cells inoculated with DENV strains from different outbreaks in Singapore. Monolayers of human retinal pigment epithelial cells (multiple primary cell isolates and the ARPE-19 cell line) were inoculated with six DENV strains, at multiplicity of infection of 10; uninfected and recombinant strain-infected controls were included where relevant. Infectivity and cell response were assessed primarily by RT-qPCR on total cellular RNA, and barrier function was evaluated as electrical resistance across monolayers. Higher viral RNA loads were measured in human retinal pigment epithelial cells infected with DENV-1 strains from the 2005 Singapore epidemic, when retinopathy was prevalent, versus DENV-1 strains from the 2007 Singapore epidemic, when retinopathy was not observed. Type I interferon (IFN) transcripts (IFN-β and multiple IFN-stimulated genes) were up-regulated, and impact on barrier function was more pronounced, for cells infected with DENV-1 strains from the 2005 versus the 2007 Singapore epidemics. Aside from serotype, strain of DENV may determine the potential to induce retinal pathology. Identification of molecular markers of disease-associated DENV strains may provide insights into the pathogenesis of dengue retinopathy.

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“…Como a doença possui uma ampla gama de manifestações 18 , um exame clínico detalhado na busca de sinais inflamatórios é imperativo, assim como a busca de fatores de risco na anamnese. Exames de imagem como a retinografia, a tomografia de coerência óptica 19 , a angiofluoresceinografia e a ultrassonografia ocular complementam a investigação e podem detectar alterações sutis não detectadas ao exame clínico 17 .…”

Section: Sífilis Ocularunclassified

Manifestações oculares de doenças sistêmicas: uveítes, Oftalmopatia de Graves e Síndrome de Sjögren

Furtado

Oliveira

Vieira

et al. 2022

Medicina (Ribeirão Preto)

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A oftalmologia é considerada uma área especializada dentro da medicina. As manifestações oculares de doenças sistêmicas permitem a interação com outras especialidades, como reumatologia, endocrinologia, infectologia, pediatria e neurologia. Diminuição da acuidade visual, dor e hiperemia ocular, ou sensação de olho seco podem ser a primeira manifestação de doenças sistêmicas, e por isso a anamnese pode nos dar pistas de doenças não diagnosticadas. O exame de fundo de olho, exibe os vasos sanguíneos de maneira não invasiva, e alterações detectadas também podem estar presente em outras estruturas, como rins, cérebro e coração. Neste artigo, detalhamos as principais doenças sistêmicas que acometem os olhos, e suas manifestações mais comuns.

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Optical Coherence Tomography Findings in Ocular Syphilis Involving the Posterior Segment of the Eye

Cited by 12 publications

References 21 publications

Syphilitic Uveitis With Diverse Clinical Presentations: Multimodal Imaging as a Useful Adjunctive Tool for Diagnosis and Treatment

Syphilitic Uveitis With Diverse Clinical Presentations: Multimodal Imaging as a Useful Adjunctive Tool for Diagnosis and Treatment

Infection of Human Retinal Pigment Epithelial Cells with Dengue Virus Strains Isolated during Outbreaks in Singapore

Manifestações oculares de doenças sistêmicas: uveítes, Oftalmopatia de Graves e Síndrome de Sjögren

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