Optical coherence tomography for quantitative surface topography

Ortíz, Sergio; Siedlecki, Damian; Remón, Laura; Marcos, Susana

doi:10.1364/ao.48.006708

Cited by 76 publications

(90 citation statements)

References 24 publications

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“…In previous works we have reported 3-D anterior segment biometry in human eyes in vivo, including anterior and posterior corneal and lenticular surface elevation maps [12][13][14][15][16][17], interocular distances along well identified axes [18] and full crystalline lens, beyond the margins of the pupil [19]. Quantitative analysis is possible by correction of distortions (fan, arising from the scanning architecture; optical, due to the refraction in the optical surfaces) and new automatic image processing algorithms that have allowed quantification.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional OCT based guinea pig eye model: relating morphology and optics

Pérez-Merino¹,

Velasco-Ocaña²,

Martinez-Enriquez³

et al. 2017

Biomed. Opt. Express

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Custom Spectral Optical Coherence Tomography (SOCT) provided with automatic quantification and distortion correction algorithms was used to measure the 3-D morphology in guinea pig eyes (n = 8, 30 days; n = 5, 40 days). Animals were measured awake in vivo under cyclopegia. Measurements showed low intraocular variability (<4% in corneal and anterior lens radii and <8% in the posterior lens radii, <1% interocular distances). The repeatability of the surface elevation was less than 2 µm. Surface astigmatism was the individual dominant term in all surfaces. Higher-order RMS surface elevation was largest in the posterior lens. Individual surface elevation Zernike terms correlated significantly across corneal and anterior lens surfaces. Higher-orderaberrations (except spherical aberration) were comparable with those predicted by OCTbased eye models.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional OCT based guinea pig eye model: relating morphology and optics

Pérez-Merino¹,

Velasco-Ocaña²,

Martinez-Enriquez³

et al. 2017

Biomed. Opt. Express

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“…We have presented recently a quantitative 3-D OCT system which allows profilometry of the ocular surfaces of the eye [36,37]. This technique was used for measurements of corneal elevation maps in vivo [38], biometry and lens alignment [39], dynamic measurement of crystalline lens radii of curvature with accommodation [20] and crystalline lens surfaces elevation maps in vivo [40].…”

Section: Introductionmentioning

confidence: 99%

OCT 3-D surface topography of isolated human crystalline lenses

Sun

Birkenfeld

Castro

et al. 2014

Biomed. Opt. Express

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Quantitative 3-D Optical Coherence Tomography was used to measure surface topography of 36 isolated human lenses, and to evaluate the relationship between anterior and posterior lens surface shape and their changes with age. All lens surfaces were fitted to 6th order Zernike polynomials. Astigmatism was the predominant surface aberration in anterior and posterior lens surfaces (accounting for ~55% and ~63% of the variance respectively), followed by spherical terms, coma, trefoil and tetrafoil. The amount of anterior and posterior surface astigmatism did not vary significantly with age. The relative angle between anterior and posterior surface astigmatism axes was on average 36.5 deg, tended to decrease with age, and was >45 deg in 36.1% lenses. The anterior surface RMS spherical term, RMS coma and 3rd order RMS decreased significantly with age. In general, there was a statistically significant correlation between the 3rd and 4th order terms of the anterior and posterior surfaces. Understanding the coordination of anterior and posterior lens surface geometries and their topographical changes with age sheds light into the role of the lens in the optical properties of the eye and the lens aging mechanism.

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“…For example, the radial scan from the MEMS mirror can cause various distortions in OCT images, since an OCT interferogram is encoded with optical path length difference, potentially causing flat surfaces to appear curved. Conventionally, this type of distortion was corrected using algorithms based on a point-to-point method [47,48], which can consume substantial computing resources. In reference [49], the authors discuss a new method that directly manipulates the original spectral interferograms in the phase domain to correct the spherical distortion.…”

Section: Image Correctionmentioning

confidence: 99%

Progress of MEMS Scanning Micromirrors for Optical Bio-Imaging

Lin

Keeler

2015

Micromachines

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Microelectromechanical systems (MEMS) have an unmatched ability to incorporate numerous functionalities into ultra-compact devices, and due to their versatility and miniaturization, MEMS have become an important cornerstone in biomedical and endoscopic imaging research. To incorporate MEMS into such applications, it is critical to understand underlying architectures involving choices in actuation mechanism, including the more common electrothermal, electrostatic, electromagnetic, and piezoelectric approaches, reviewed in this paper. Each has benefits and tradeoffs and is better suited for particular applications or imaging schemes due to achievable scan ranges, power requirements, speed, and size. Many of these characteristics are fabrication-process dependent, and this paper discusses various fabrication flows developed to integrate additional optical functionality beyond simple lateral scanning, enabling dynamic control of the focus or mirror surface. Out of this provided MEMS flexibility arises some challenges when obtaining high resolution images: due to scanning non-linearities, calibration of MEMS scanners may become critical, and inherent image artifacts or distortions during scanning can degrade image quality. Several reviewed methods and algorithms have been proposed to address these complications from MEMS scanning. Given their impact and promise, great effort and progress have been made toward integrating MEMS and biomedical imaging.

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Optical coherence tomography for quantitative surface topography

Cited by 76 publications

References 24 publications

Three-dimensional OCT based guinea pig eye model: relating morphology and optics

Three-dimensional OCT based guinea pig eye model: relating morphology and optics

OCT 3-D surface topography of isolated human crystalline lenses

Progress of MEMS Scanning Micromirrors for Optical Bio-Imaging

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