Optical coherence tomography in diagnostics of small choroidal melanoma

Myakoshina, E. B.; Saakyan, S.V.

doi:10.17116/oftalma202013601156

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Reporting other OCT features examined in this study, we found subretinal fluid, retinal edema over the lesion, a change in the ellipsoid zone over the tumor, and RPE changes over the lesion like RPE atrophy or RPE hyperplasia more frequently in patients with choroidal melanomas than with choroidal nevi. These findings align with the current literature [ 14 , 19 , 31 ] and thus strengthen the understanding of OCT-guided discrimination between the two pathologies. As for the appearance of indeterminate choroidal melanocytic lesions on OCT and autofluorescence imaging, some studies show that they resemble choroidal melanomas [ 12 , 32 ], which we also found in our investigation.…”

Section: Discussionsupporting

confidence: 91%

Assessing Choroidal Nevi, Melanomas and Indeterminate Melanocytic Lesions Using Multimodal Imaging—A Retrospective Chart Review

et al. 2022

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Using multimodal imaging, the literature proposed the following risk factors for choroidal nevus growth into melanoma: increased tumor thickness, subretinal fluid, decreased visual acuity, presence of orange pigment, ultrasound acoustic hollowness, and increased tumor diameter. This study investigated the presence of the mentioned risk factors in choroidal nevi, choroidal melanomas, and indeterminate choroidal melanocytic lesions. This retrospective, single-center chart review assessed choroidal melanocytic tumors with multimodal imaging. We defined our primary outcome as the cumulative presence of mentioned risk factors. Further, we evaluated various optical coherence tomography (OCT), ultrasound, and autofluorescence findings. We analyzed 51 tumors from 49 patients during the period from April 2008 to June 2021. The median (IQR) age was 64.0 (56.0 to 70.5) years, with 23 of 49 (46.9%) patients being female. The follow-up time for all tumors was median (IQR) 25.0 (12.0 to 39.0) months. The choroidal nevi had a median (range) risk score of 0.0 (0.0 to 3.0), and the choroidal melanoma of 5.0 (3.0 to 6.0), with statistically significant different ratings (p < 0.001). Multimodal imaging creates a score that may help to distinguish choroidal nevi from choroidal melanomas objectively.

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Section: Discussionsupporting

confidence: 91%

Assessing Choroidal Nevi, Melanomas and Indeterminate Melanocytic Lesions Using Multimodal Imaging—A Retrospective Chart Review

et al. 2022

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“…Из клинико-инструментальных характеристик «To Find Small Ocular Melanoma Doing Imaging (TFSOM-DIM)» C. Shields и соавт. считают наиболее информативными следующие факторы риска малигнизации невуса хориоидеи: толщина опухоли более 2 мм, наличие субретинального экссудата, снижение остроты зрения, наличие «полей оранжевого пигмента» на поверхности опухоли, симптом «пустоты» по данным УЗИ, диаметр опухоли более 5 мм по данным ретинофото [3,17]. В среднем при 5-летнем наблюдении малигнизация невуса хориоидеи составляет 1 % при отсутствии указанных факторов риска и 11, 22, 34, 51, 55 % -при наличии от 1 до 5 факторов риска соответственно [3].…”

Section: Discussionunclassified

Association of clinical, instrumental and molecular genetic predictors with the risk of development and tumor progression of melanocytic intraocular neoplasms

Saakyan

Tsygankov

Myakoshina

et al. 2020

Rossijskij oftalʹmologičeskij žurnal

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“…Previous studies have shown that 60% of the subretinal fluid in a choroidal melanoma is patchy, while 40% is diffuse ( 46 ). EDI-OCT is an effective tool to identify structural changes in the retina in patients with small choroidal melanomas ( 47 ). This method can show retinal edema, “fluffy” or lost photoreceptor cells, an irregular ganglion cell layer, broken connections between internal and external segments, an irregular inner plexus layer, the loss of external membrane, and other structural damage ( 26 ).…”

Section: Diagnosis Of Choroid Melanomamentioning

confidence: 99%

Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas

Wang

Zhang

et al. 2021

Front. Oncol.

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Choroidal melanomas are the most common ocular malignant tumors worldwide. The onset of such tumors is insidious, such that affected patients often have no pain or obvious discomfort during early stages. Notably, enucleation is required for patients with a severe choroidal melanoma, which can seriously impact their quality of life. Moreover, choroidal melanomas metastasize early, often to the liver; this eventually causes affected patients to die of liver failure. Therefore, early diagnosis of choroidal melanomas is extremely important. Unfortunately, an early choroidal melanoma is easily confused with a choroidal nevus, which is the most common benign tumor of the eye and does not often require surgical treatment. This review discusses recent advances in the use of multimodal and molecular imaging to identify choroidal melanomas and choroidal nevi, detect early metastasis, and diagnose patients with choroidal melanomas.

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Optical coherence tomography in diagnostics of small choroidal melanoma

Cited by 8 publications

References 22 publications

Assessing Choroidal Nevi, Melanomas and Indeterminate Melanocytic Lesions Using Multimodal Imaging—A Retrospective Chart Review

Assessing Choroidal Nevi, Melanomas and Indeterminate Melanocytic Lesions Using Multimodal Imaging—A Retrospective Chart Review

Association of clinical, instrumental and molecular genetic predictors with the risk of development and tumor progression of melanocytic intraocular neoplasms

Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas

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