Optical coherence tomography to detect acute esophageal radiation‐induced damage in mice: A validation study

Jelvehgaran, Pouya; Bruin, Daniël M. de; Khmelinskii, Artem; Borst, Gerben R.; Steinberg, J.; Song, Ji‐Ying; Vos, Judith de; Leeuwen, Ton G. van; Alderliesten, Tanja; Boer, Johannes F. de; Herk, Marcel van

doi:10.1002/jbio.201800440

Cited by 4 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, rehabilitation nursing was used to intervene patients undergoing radiotherapy for esophageal cancer. The results showed that the total effective rate of improving swallowing function in IG was 82.8% (53/64), significantly higher than 57.8% in the control group, which was consistent with the findings in stroke patients with hemiplegia [ 25 ]. Radiotherapy can cause different degrees of radiotherapy reaction during the treatment of esophageal cancer.…”

Section: Discussionsupporting

confidence: 88%

Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer

Zeng

Wang

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

Objective. To seek the improvement of rehabilitation nursing intervention on dysphagia and quality of life of patients with esophageal cancer undergoing radiotherapy. Methods. A total of 109 patients with esophageal cancer undergoing radiotherapy were selected as research objects. According to the random number table, they were separated into the control group (CG) and intervention group (IG), with 45 cases in CG and 64 cases in IG. In CG, patients were given routine nursing intervention, while those in IG were given rehabilitation nursing intervention. After intervention, the degree of acute radiation injury and the improvement of swallowing function were observed to compare the self-nursing ability, quality of life, and incidence of complications between the two groups. Results. The degree of injury in CG was heavier than that in IG. The improvement of swallowing function in IG was better than that in CG. The scores of self-nursing ability and life quality in IG were higher than those in CG, with statistically significant differences ( p < 0.05 ). The incidence of complications in IG was obviously lower than that in CG ( p < 0.05 ). Conclusion. Rehabilitation nursing intervention can ameliorate dysphagia, improve the quality of life, and reduce the incidence of complications for patients with esophageal cancer undergoing radiotherapy. It is worthy of clinical application.

show abstract

Section: Discussionsupporting

confidence: 88%

Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer

Zeng

Wang

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…The advent of the MR guided radiotherapy will greatly facilitate such studies and our work gives an indication of the kind of changes to expect in the esophagus. Furthermore, this study facilitated the comparison between MRI and OCT imaging modalities to detect ARIED [17], affecting future clinical research.…”

Section: Discussionmentioning

confidence: 99%

“…In current clinical practice, ARIED is scored based solely on patient symptoms [13, 14]. ARIED can cause reduced food intake, nausea, dysplasia, odynophagia, anorexia, and other complications, which may interrupt treatment [3, 7, 13–17]. Treatment interruptions can affect tumor control [15, 17] and can likely be avoided if we can detect ARIED prior to patients developing symptoms and start countermeasures over time.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, an in-depth understanding of ARIED can help to optimize IGRT planning, which may better control the tumor while reducing complications to nearby healthy regions. Various medical imaging modalities can visualize ARIED, such as white light endoscopy (WLE), positron emission tomography (PET) [18], and more recently, optical coherence tomography (OCT) [15, 17]. With the advent of magnetic resonance imaging (MRI) guided radiotherapy, we may be able to non-invasively detect and monitor ARIED.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of acute esophageal radiation-induced damage using magnetic resonance imaging: a feasibility study in mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

BackgroundThoracic and head and neck cancer radiation therapy (RT) can cause damage to nearby healthy organs such as the esophagus, causing acute radiation-induced esophageal damage (ARIED). A non-invasive method to detect and monitor ARIED can facilitate optimizing RT to avoid ARIED while improving local tumor control. Current clinical guidelines are limited to scoring the esophageal damage based on the symptoms of patients. Magnetic resonance imaging (MRI) is a non-invasive imaging modality that may potentially visualize radiation-induced organ damage. We investigated the feasibility of using T2-weighted MRI to detect and monitor ARIED using a two-phased study in mice.MethodsThe first phase aimed to establish the optimal dose level at which ARIED is inducible and to determine the time points where ARIED is detectable. Twenty four mice received a single dose delivery of 20 and 40 Gy at proximal and distal spots of 10.0 mm (in diameter) on the esophagus. Mice underwent MRI and histopathology analysis with esophageal resection at two, three, and 4 weeks post-irradiation, or earlier in case mice had to be euthanized due to humane endpoints. In the second phase, 32 mice received a 40 Gy single dose and were studied at two, three, and 7 days post-irradiation. We detected ARIED as a change in signal intensity of the MRI images. We measured the width of the hyperintense area around the esophagus in all mice that underwent MRI prior to and after irradiation. We conducted a blind qualitative comparison between MRI findings and histopathology as the gold standard.Results/conclusionsA dose of 40 Gy was needed to induce substantial ARIED. MRI detected ARIED as high signal intensity, visible from 2 days post-irradiation. Quantitative MRI analysis showed that the hyperintense area around the esophagus with severe ARIED was 1.41 mm wider than with no damage and MRI-only mice. The overall sensitivity and specificity were 56 and 43% respectively to detect any form of ARIED. However, in this study MRI correctly detected 100% of severe ARIED cases. Our two-phased preclinical study showed that MRI has the potential to detect ARIED as a change in signal intensity and width of enhancement around the esophagus.

show abstract

“…Optical coherence tomography (OCT) is a recent, rapidly developing, high-definition light imaging technique (10) which can provide orthotropic images by measuring tissue backscattered light to obtain high-resolution crosssectional tomography images of the microstructure inside biological tissues. It is characterized by its biopsy ability, non-invasiveness, and real-time detection (11,12). The axial resolution of OCT can reach more than 10 times that of endoscopic ultrasound, reaching the micron level (13).…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of acute and chronic colitis in mice by optical coherence tomography

Ding²,

Luo³

et al. 2022

Quant Imaging Med Surg

View full text Add to dashboard Cite

Background: The differential diagnosis of acute and chronic colitis remains a common clinical problem.Optical coherence tomography (OCT) is a non-invasive, high-resolution imaging technique that can be used to measure morphological changes in the intestinal wall and estimate intestinal inflammation. We aimed to conduct an ex vivo experiment on a mouse model investigate the value of OCT as a tool for the differential diagnosis of acute and chronic colitis.Methods: Mice were administered dextran sulfate sodium salt (DSS) to construct acute and chronic colitis models. Acutely-and chronically-affected intestinal walls were scanned by OCT, and then the scanned colonic tissue samples were stained with hematoxylin and eosin (HE). Structural and morphological changes indicating inflammation in the intestinal wall were evaluated in the HE sections and OCT images using different parameters. The parameters were used in one-way analysis of variance (ANOVA) to screen for a differential diagnosis of acute or chronic colitis.Results: For the HE sections, the angle of the mucosal folds, length of the basilar part, and submucosal height and area were statistically significant parameters in the comparisons between the mice with acute colitis and the control-group mice (P<0.05). In the comparisons between chronic colitis mice and controlgroup mice, the angle of the mucosal folds, length of the basilar part, submucosal height and area, muscularis thickness, submucosal height + muscularis thickness, and mucosal thickness were statistically significant parameters (P<0.05). Finally, in the comparisons between acute colitis mice and those with chronic colitis, the angle of the mucosal folds, submucosal height and area, muscularis thickness, submucosal height + muscularis thickness, and mucosal thickness were statistically significant parameters (P<0.05). For the OCT images, only the length of the basilar part and submucosal height + muscularis thickness were statistically significant parameters between the acute colitis mice and control-group mice (P<0.05). The length of the basilar part and submucosal height + muscularis thickness were statistically significant between chronic colitis mice and control-group mice (P<0.05). In the comparisons between acute colitis mice and those with chronic colitis, only submucosal height + muscularis thickness was a statistically significant parameter (P<0.05). Research: Reporting of In Vivo Experiments (ARRIVE) reporting checklist (available at https://qims.amegroups. com/article/view/10.21037/qims-21-1062/rc). Methods Animals and materialsHealthy female BALB/c mice (6-8 weeks old; 18-22 g) were purchased from Wu's Experimental Animal Center (Minhou Conclusions: Certain intestinal wall parameters in OCT can be used to make a differential diagnosis between acute and chronic colitis possible. This study contributes to constructing a potential diagnostic system for evaluating colorectal inflammation using OCT.

show abstract

Optical coherence tomography to detect acute esophageal radiation‐induced damage in mice: A validation study

Cited by 4 publications

References 23 publications

Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer

Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer

Evaluation of acute esophageal radiation-induced damage using magnetic resonance imaging: a feasibility study in mice

Differential diagnosis of acute and chronic colitis in mice by optical coherence tomography

Contact Info

Product

Resources

About