Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method

Vizet, Jérémy; Manhas, Sandeep; Tran, Jacqueline; Validire, Pierre; Benali, Abdelali; Garcia-Caurel, Enric; Pierangelo, Angelo; Martino, A. De; Pagnoux, Dominique

doi:10.1117/1.jbo.21.7.071106

Cited by 29 publications

(20 citation statements)

References 28 publications

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“…However, many studies revealed that linear retardance is largely dominant in biological tissues; indeed, polarimetric measurements performed on such tissues in backscattering configuration revealed that this type of structures exhibits very low circular retardance 1 , 13 , 40 , 41 . Consequently, R ≈ R L , and the Mueller matrix M R can be determined by 32 , 40 : where α is the orientation of one eigenaxis of the sample (also named “Azimuth” in this article), and can be determined using the following formula: …”

Section: Methodsmentioning

confidence: 99%

“…Hence, the in vivo polarimetric systems presented to date are almost exclusively based on a relatively simple technique using Orthogonal State Contrast (OSC) 2 , 26 polarimetry. Several types of endoscopic polarimetric systems (needed for the exploration of inner cavities of the human body) have also been proposed in recent years 27 – 32 , but they have only been tested on ex vivo tissue samples. Very few in vivo Mueller polarimetric systems have been demonstrated and/or tested, such as one for studying the collagenase of mice 33 , and another for application in opthalmology for human patients 34 .…”

Section: Introductionmentioning

confidence: 99%

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In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

Vizet

Rehbinder

Deby

et al. 2017

Sci Rep

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Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the in vivo application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested in vivo on a number of patients in the field.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

Vizet

Rehbinder

Deby

et al. 2017

Sci Rep

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“…In this method, so-called "two-wavelength differential method (TWDM)", we simultaneously launch two probe beams at two very close wavelengths λ 1 and λ 2 in the fiber (Fig. 1) [19]. The beam at λ 1 is totally reflected by a dichroic mirror set at the output end of the fiber, making it possible to measure the Mueller matrix of this fiber only, on a round trip of the light.…”

Section: Introductionmentioning

confidence: 99%

Design of an endomicroscope including a resonant fiber-based microprobe dedicated to endoscopic polarimetric imaging for medical diagnosis

Buckley¹,

Fabert²,

Kinet³

et al. 2020

Biomed. Opt. Express

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We report on a novel endomicroscope, to the best of our knowledge, designed for achieving full 4×4 Mueller polarimetric images of biological tissues through a fiber endoscope for medical diagnosis. The polarimetric technique is based on a previously published twowavelength differential method (TWDM). A key component of the endomicroscope is a resonant fiber-based microprobe including a highly-selective fiber Bragg grating (FBG), free of detrimental polarimetric effects, photo written in the core of the fiber, near the output face. By means of the TWDM, and using the specially designed microprobe (diameter 2.9 mm, length 30 mm), full Mueller images of 250×250 pixels were produced at the rate of 1 image/2 s through a 2 m single mode fiber, paving the way to in vivo applications in polarimetric endomicroscopy.

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“…Moreover this polarimetric technique provides a macroscopic field of view (≈10 cm 2 ), and the delineation of suspicious areas can be imaged without any tissue contact. Through the integration of this technology into conventional instruments (e.g., colposcope, endoscope), polarimetric imaging is a promising tool for in vivo cancer detection and staging [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Polarimetric measurement utility for pre-cancer detection from uterine cervix specimens

Kupinski¹,

Boffety²,

Goudail³

et al. 2018

Biomed. Opt. Express

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Prior work demonstrated significant contrast in visible wavelength Mueller matrix images for healthy and pre-cancerous regions of excised cervical tissue. This work demonstrates post-processing compressions of the full Mueller matrix that preserve detection performance. The purpose of this post-processing is to understand polarimetric measurement utility for computing mathematical observers and designing future imaging protocols. The detection performance of the full Mueller matrix, and both linear and non-linear parameters of the Mueller matrix will be compared. The area under the receiver operating characteristic (ROC) curve, otherwise known as the AUC, is the gold standard metric to quantify detection performance in medical applications. An AUC = 1 is perfect detection and AUC = 0.5 is the performance of guessing. Either the scalar retardance or the 3 smallest eigenvalues of the coherency matrix yield an average AUC of 0.94 or 0.93, respectively. When these four non-linear parameters are used simultaneously the average AUC is 0.95. The J-optimal Channelized Quadratic Observer (J-CQO) method for optimizing polarimetric measurements demonstrates equivalent AUC values for the full Muller matrix and 6 J-CQO optimized measurements. The advantage of this optimization is that only 6 measurements, instead of 16 for the full Mueller matrix, are required to achieve this AUC.

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Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method

Cited by 29 publications

References 28 publications

In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

Design of an endomicroscope including a resonant fiber-based microprobe dedicated to endoscopic polarimetric imaging for medical diagnosis

Polarimetric measurement utility for pre-cancer detection from uterine cervix specimens

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