Development of reliable, sensitive, selective, and miniaturized sensing technologies is critical for health assessment and early diagnosis and treatment of diseases/anomalies while simultaneously mitigating the challenges associated with in vivo measurements. Some critical constraints to the realization of in vivo measurements include the necessity to fabricate the sensor on a tightly constrained footprint while ensuring acceptable biocompatibility, accuracy, and reliability. The inherent light-guiding properties of optical fibers over long distances, their microscopic cross-section that can be structured at the nanoscale to manipulate the light transmittance/reflectance spectrum, excellent biocompatibility enabling their efficient integration with bio-recognition molecules, immunity to electromagnetic interference, mechanical flexibility, and low cost have been inviting research attention to utilize these unique features for in vivo and label-free point-ofcare diagnostics. Hence, fiber-optic biosensing has become a promising research thrust, with a plethora of emerging methodologies to develop ultrasensitive and selective sensing probes.A unified presentation of the research trends on biosensors incorporated into optical fibers is presented.