Optical Imaging of Intrinsic Signals in Chinchilla Auditory Cortex

Harrison, Robert V.; Harel, Noam; Kakigi, Akinobu; Raveh, Eyal; Mount, Richard J.

doi:10.1159/000013791

Cited by 37 publications

(35 citation statements)

References 32 publications

(45 reference statements)

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“…Results of recent optical imaging studies of auditory cortex in ketamine-anesthetized chinchillas (Harrison et al 1998) and barbiturate-anesthetized cats (Dinse et al 1996) are similar to those obtained with 540-nm light in the present study. Harrison et al (1998) recorded tone-evoked optical signals at 540 nm with similar time course and topography to those reported here.…”

Section: Comparison With Previous Studies Of Auditory Cortexsupporting

confidence: 90%

“…A similar success rate has been reported for imaging at 540 nm in chinchilla auditory cortex (Harrison et al 1998). In two of the unsuccessful cases, normal multiunit responses were recorded after the imaging sessions, indicating that our failure to record optical signals was not a result of a physiologically unresponsive auditory cortex.…”

Section: Stimulus-evoked Optical Signalssupporting

confidence: 81%

“…The spontaneous signals measured by Mayhew et al could be as large as 1-2% of the total reflected light signal; whereas, the "mapping signals" used to define functional architecture by intrinsic signal based optical imaging are typically an order of magnitude smaller Grinvald et al 1988). At least one other optical imaging study of auditory cortex has reported "spontaneous waves of cortical activity" with a cycle of 5-10 s that acted as a major source of interference (Harrison et al 1998). In the present FIG. 6.…”

Section: Spontaneous Optical Signalsmentioning

confidence: 99%

“…Recently, several groups have used OI of intrinsic signals to study the topography of stimulus evoked activity in auditory cortex of rodents (Bakin et al 1996;Harrison et al 1998;Hess and Scheich 1996). Results of these studies differ from those of single-unit mapping studies of cat A1 (Heil et al 1994;Phillips et al 1994) in several respects, including threshold and time course of evoked activity, spatial distribution of tone-evoked activity, and effects of changing sound pressure level (SPL).…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous and Stimulus-Evoked Intrinsic Optical Signals in Primary Auditory Cortex of the Cat

Spitzer

Calford

Clarey

et al. 2001

Journal of Neurophysiology

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. Spontaneous and stimulus-evoked intrinsic optical signals in primary auditory cortex of the cat. J Neurophysiol 85: [1283][1284][1285][1286][1287][1288][1289][1290][1291][1292][1293][1294][1295][1296][1297][1298] 2001. Spontaneous and tone-evoked changes in light reflectance were recorded from primary auditory cortex (A1) of anesthetized cats (barbiturate induction, ketamine maintenance). Spontaneous 0.1-Hz oscillations of reflectance of 540-and 690-nm light were recorded in quiet. Stimulation with tone pips evoked localized reflectance decreases at 540 nm in 3/10 cats. The distribution of patches "activated" by tones of different frequencies reflected the known tonotopic organization of auditory cortex. Stimulus-evoked reflectance changes at 690 nm were observed in 9/10 cats but lacked stimulus-dependent topography. In two experiments, stimulus-evoked optical signals at 540 nm were compared with multiunit responses to the same stimuli recorded at multiple sites. A significant correlation (P Ͻ 0.05) between magnitude of reflectance decrease and multiunit response strength was evident in only one of five stimulus conditions in each experiment. There was no significant correlation when data were pooled across all stimulus conditions in either experiment. In one experiment, the spatial distribution of activated patches, evident in records of spontaneous activity at 540 nm, was similar to that of patches activated by tonal stimuli. These results suggest that local cerebral blood volume changes reflect the gross tonotopic organization of A1 but are not restricted to the sites of spiking neurons.

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Section: Comparison With Previous Studies Of Auditory Cortexsupporting

confidence: 90%

Section: Stimulus-evoked Optical Signalssupporting

confidence: 81%

Section: Spontaneous Optical Signalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous and Stimulus-Evoked Intrinsic Optical Signals in Primary Auditory Cortex of the Cat

Spitzer

Calford

Clarey

et al. 2001

Journal of Neurophysiology

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“…Propagating waves have also been demonstrated in the auditory cortex (Harrison et al, 1998;Nelken et al, 2004;Song et al, 2006). They are of cortical (or thalamocortical) origin, because they can be evoked also by intracortical microstimulation (Song et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Patterns of Cortical Activity with Bilateral Cochlear Implants in Congenital Deafness

Kral¹,

Tillein²,

Hubka³

et al. 2009

J. Neurosci.

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Congenital deafness affects developmental processes in the auditory cortex. In this study, local field potentials (LFPs) were mapped at the cortical surface with microelectrodes in response to cochlear implant stimulation. LFPs were compared between hearing controls and congenitally deaf cats (CDCs). Pulsatile electrical stimulation initially evoked cortical activity in the rostral parts of the primary auditory field (A1). This progressed both in the approximate dorsoventral direction (along the isofrequency stripe) and in the rostrocaudal direction. The dorsal branch of the wavefront split into a caudal branch (propagating in A1) and another smaller one propagating rostrally into the AAF (anterior auditory field). After the front reached the caudal border of A1, a "reflection wave" appeared, propagating back rostrally. In total, the waves took ϳ13-15 ms to propagate along A1 and return back. In CDCs, the propagation pattern was significantly disturbed, with a more synchronous activation of distant cortical regions. The maps obtained from contralateral and ipsilateral stimulation overlapped in both groups of animals. Although controls showed differences in the latency-amplitude patterns, cortical waves evoked by contralateral and ipsilateral stimulation were more similar in CDCs. Additionally, in controls, LFPs with contralateral and ipsilateral stimulation were more similar in caudal A1 than in rostral A1. This dichotomy was lost in deaf animals. In conclusion, propagating cortical waves are specific for the contralateral ear, they are affected by auditory deprivation, and the specificity of the cortex for stimulation of the contralateral ear is reduced by deprivation.

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In vivo optical imaging of tone‐evoked activity in the dorsal cochlear nucleus with a voltage sensitive dye

Kaltenbach

Zhang

2004

J of Neuroscience Research

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We investigated the use of optical imaging for observing the spatial patterns of neural activation in the dorsal cochlear nucleus (DCN) of hamsters during tonal stimulation. The patterns of activation were studied in the DCN, in vivo, following application of a voltage sensitive dye, Di-2-ANEPEQ, to the DCN surface. Beginning 60-90 min following dye application, tones were presented to the ipsilateral ear. Electrophysiological recordings after dye application revealed no significant toxicity of Di-2-ANEPEQ that affected the frequency-tuning properties of DCN neurons. We examined areas of activation in response to each of a series of test stimuli consisting of pure tones ranging in frequency from 2 to 20 kHz. For each stimulus condition, images were collected over a stimulus interval of 400 msec and averaged over 32 stimulus repetitions. These images revealed areas of activation with definable epicenters. The epicenters shifted from lateral to more medial locations on the DCN surface with increases in stimulus frequency. Comparison with electrophysiological data indicated a close parallel between the tonotopic gradient defined by optical imaging and that defined by the distribution of characteristic frequencies. The principal temporal and spatial features of these optical responses are described.

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Optical Imaging of Intrinsic Signals in Chinchilla Auditory Cortex

Cited by 37 publications

References 32 publications

Spontaneous and Stimulus-Evoked Intrinsic Optical Signals in Primary Auditory Cortex of the Cat

Spontaneous and Stimulus-Evoked Intrinsic Optical Signals in Primary Auditory Cortex of the Cat

Spatiotemporal Patterns of Cortical Activity with Bilateral Cochlear Implants in Congenital Deafness

In vivo optical imaging of tone‐evoked activity in the dorsal cochlear nucleus with a voltage sensitive dye

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