Optical – Magnetic probe for evaluating cancer therapy

Rapid Gelation of Tough and Anti‐Swelling Hydrogels under Mild Conditions for Underwater Communication

“…toughening hydrogels, enabling them to sustain extreme loads such as tension, compression, distortion, etc. [7][8][9] These tough hydrogels hold great potential in advanced applications, as exemplified by soft robotics, wearable sensors, and actuators. [10,11] An emerging field named hydrogel-based devices rapidly evolves, outlining the roadmap for the development of next-generation soft materials for human-machine interfaces.…”

Degradable Magnetic Nanoplatform with Hydroxide Ions Triggered Photoacoustic, MR Imaging, and Photothermal Conversion for Precise Cancer Theranostic

“…Photothermal therapy (PTT) as noninvasive technology that utilizes light-absorbing materials to generate hyperthermia (>42 °C) has been widely employed to effectively ablate various kinds of solid tumor under near-infrared (NIR) laser irradiation. , However, most photothermal agents often displayed the “always-on” generating hyperthermia effect and unavoidable nonspecificity biodistribution, resulting in the potential damage of normal tissues surrounding the tumor. , Thereby, it is of great importance to develop a novel strategy to reduce the hyperthermia-induced damage toward normal tissues and to accurately monitor the temperature distribution inside tumor during PTT for reducing side effects in cancer therapy. , As we know, with the rapid cell growth and inadequate blood supply the tumor microenvironment is more acidic than normal tissues. − On the basis of the difference of acidic tumor microenvironment and normal tissues, several pH-dependent inorganic nanomaterials (such as MoO x , VS 2 , and ReO 3 ) have been developed as biodegradable photothermal agents with the advantages of both EPR effects and body clearance. ,− Although the surface temperature of the tumor could be feasibly monitored using the infrared thermal imaging camera during PTT, it is still difficult to monitor the real temperature change inside tumors (especially for more than 1 cm) . Hopefully, PA imaging is a noninvasive diagnostic technology that combines the features of optical imaging and ultrasound imaging with high resolution and real-time imaging capabilities. − Moreover, MRI is widely regarded as a powerful noninvasive technology with high spatial resolution and deep tissue penetration. − Thus, it is highly desired to develop nanomaterials that were integrated with PA/MRI dual-mode imaging for guiding PTT, tumor-microenvironment response and biodegradability, so as to reduce phototoxicity and improve specificity of treatment.…”

A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer

“…Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), has the advantages of non-invasiveness, high selectivity, negligible drug resistance and low toxic side effects. 1,2 Unfortunately, the limitations of single treatment are becoming increasingly apparent, i.e ., the hypoxic microenvironment of tumor reduces the efficacy of oxygen-dependent PDT, whereas the rapid heating of PTT can evoke a heat shock immune response and increase the thermotolerance of tumor cells. 3,4 Therefore, the combination of PTT and PDT is undoubtedly the desired choice for achieving ideal therapeutic outcomes.…”