Optical measurement of creatinine in spent dialysate

Tomson, Ruth; Fridolin, Ivo; Uhlin, Fredrik; Holmar, Jana; Lauri, Kai; Luman, Merike

doi:10.5414/cn107338

Cited by 11 publications

(14 citation statements)

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“…It has been shown previously that it is possible to monitor creatinine concentration in spent dialysate with the UV absorbance technique [8]. As the result of the regression analysis between creatinine concentration in blood and in spent dialysate show a strong linear relationship (R 2 =O.932) (Fig.…”

Section: Discussionmentioning

confidence: 91%

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Lean body mass assessment based on UV-absorbance in spent dialysate

Tomson

Fridolin

Luman

2014

2014 14th Biennial Baltic Electronic Conference (BEC)

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The aim of the study was to explore the possibility of assessing lean body mass (LBM) based on UV-absorbance measurements in spent dialysate. Nine patients on chronic three times-a-week haemodialysis (HD) were studied. A double-beam spectrophotometer was used for the determination of UV absorbance in the collected spent dialysate samples. LBM was calculated based on creatinine concentration in blood (LBMblood), creatinine concentration in spent dialysate (LBMdialysate) and UV absorbance in spent dialysate (LBMa). Although LBMa was slightly lower compared to LBMblood, the estimates based on UV absorbance in spent dialysate were not statistically different from LBMblood' In summary, the results show that it is possible to asses LBM based on UV -absorbance in spent dialysate.

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Section: Discussionmentioning

confidence: 91%

“…It has been shown previously that the most suitable wavelength for the monitoring of creatinine removal during dialysis in spent dialysate is 299 nm [8]. Therefore, independent variables included in the regression analysis were UV -absorbance values in the spent dialysate samples at the wavelength 299 nm.…”

Section: Discussionmentioning

confidence: 99%

Lean body mass assessment based on UV-absorbance in spent dialysate

Tomson

Fridolin

Luman

2014

2014 14th Biennial Baltic Electronic Conference (BEC)

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“…When connected to EHRs, this continuous clearance monitoring can lead to real-time decision support thus facilitating the adjustment of dialysis prescriptions and timely interventions [7,44]. Similarly, ultraviolet absorbance in dialysate can help monitor dose delivery, allowing for timely prescription adjustments [3,49]. …”

Section: Leveraging Data Capture In Dialysis To Improve Patient Carementioning

confidence: 99%

Integrating Real Time Data to Improve Outcomes in Acute Kidney Injury

Hirsch

Mohan²

2015

Nephron

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Critically ill patients with acute kidney injury requiring renal replacement therapy have a poor prognosis. Despite well-known factors, which contribute to outcomes, including dose delivery, patients frequently miss the target dose and volume removal. One major barrier to effective care of these patients is the traditional dissociation of dialysis device data from other clinical information systems, notably the electronic health record (EHR). This lack of integration and the resulting manual documentation leads to errors and biases in documentation and missed opportunities to intervene in a timely fashion. This review summarizes the technological advancements facilitating direct connection of dialysis devices to EHRs. This connection facilitates automated data capture of many variables - including delivered dose, ultrafiltration rate and pressure measurements - which in turn can be leveraged for data mining, quality improvement and real-time targeted therapy adjustments. These interventions hold the promise to significantly improve outcomes for this patient population.

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“…For the determination of UV-absorbance (A) in the spent dialysate/ultrafiltrate, described earlier [9][10][11] , a double-beam spectrophotometer (V-570, UV/VIS/NIR spectrophotometer and software version 1.53.01 for Windows, JASCO Corp., Japan) with an accuracy of ±0.3% was used. Scanning at the UV-range 190-400 nm was performed after each session using pure dialysate as reference.…”

Section: Uv-absorbance Scanningmentioning

confidence: 99%

“…Our group has previously shown possibilities to estimate the removal of small water soluble waste solutes during HD, utilizing UV-absorbance within a wavelength range of 280-297 nm [8][9][10] . Since urea certainly is not a representative for all removed solutes, and is known to be rather non-toxic, an optical monitoring technique that is suitable for middle molecule removal could be a valuable complement to urea-based dialysis dose parameters.…”

Section: Introductionmentioning

confidence: 99%

Optical Estimation of Beta 2 Microglobulin during Hemodiafiltration - Does It Work?

et al. 2015

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Background: Currently, urea reduction seems to be the most widely used dialysis dose parameter. The aim of this study was to investigate the possibility to monitor beta 2-microglobulin (β2-M) elimination by utilizing the ultraviolet (UV) absorbance of spent dialysate. Methods: Blood and spent dialysate were collected during two week's sessions in 8 patients, one week in hemodialysis (HD) and one in hemodiafiltration (HDF). Correlation analysis between UV-wavelengths and concentrations of solutes in spent dialysate was performed. The reduction ratio (RR) of concentrations in blood, dialysate and UV-absorbance were compared. Results: Differences between HD and HDF were discovered in wavelength correlation maxima for the solutes. Relative error in RR (%) was larger (p < 0.05) for β2-M than for the other solutes. The most reasonable explanation is that β2-M does not absorb UV-radiation; instead, the absorbance of surrogate substances is measured. Conclusion: A high correlation between UV-absorbance and β2-M can be achieved for HDF but not for HD. Still, UV-absorbance could perhaps be used in solely HDF mode for estimation of β2-M removal.

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Optical measurement of creatinine in spent dialysate

Abstract: In summary, creatinine removal during dialysis can be estimated as reduction ratio and total removed creatinine with the UV-absorbance technique.

Cited by 11 publications

References 0 publications

Lean body mass assessment based on UV-absorbance in spent dialysate

Lean body mass assessment based on UV-absorbance in spent dialysate

Integrating Real Time Data to Improve Outcomes in Acute Kidney Injury

Optical Estimation of Beta 2 Microglobulin during Hemodiafiltration - Does It Work?

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