Optical monitoring of stress-related changes in the brain tissues and vessels associated with hemorrhagic stroke in newborn rats

Abstract

Stress is a major factor for a risk of cerebrovascular catastrophes. Studying of mechanisms underlying stress-related brain-injures in neonates is crucial for development of strategy to prevent of neonatal stroke. Here, using a model of sound-stress-induced intracranial hemorrhages in newborn rats and optical methods, we found that cerebral veins are more sensitive to the deleterious effect of stress than arteries and microvessels. The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke.

Characterization of cerebral blood flow dynamics with multiscale entropy

“…LSCI experimental data allowed us to understand that accumulation of extensive blood in venous network is a crucial factor for stress-induced critical changes in cerebral vessels related to intracranial hemorrhages. [23][24][25] With LSCI, we also found that the cerebral veins are more sensitive to adrenergic stimulation under normal state and during stress. Full-¯eld imaging of cerebral vessels in rats represents an important new insight in our understanding how the brain responds to stress: after stress-induced intracranial hemorrhages, rats demonstrate a typical venous relaxation due to activation of a special type of vascular receptors \anarchists" that are stimulated by adrenalinethe main hormone of stress but not nervous system.…”

Multifractality in cerebrovascular dynamics: an approach for mechanisms-related analysis

“…Unlike previous studies [15,16] , here we quantify complexity of the CBF-dynamics associated with individual regulatory mechanics and analyze how the pharmacologically induced acute peripheral hypertension influences the blood flow velocity in cerebral vessels of different size. In order to do this, three complexity measures are estimated for each rat describing the macroscopic CBF-dynamics in the sagittal sinus related to the frequency ranges I, II, and III.…”

“…Recent works showed an essential potential of the WTMMapproach in characterizing functional distortions in the cerebrovascular dynamics [15,16] . To assess such distortions noninvasively, changes in the cerebral blood flow (CBF) are typically analyzed with the laser speckle contrast imaging (LSCI) [17,18] or other optical coherent-domain methods that possess a high spatio-temporal resolution.…”

Влияние Потери Данных На Диагностику Сложных Режимов Динамики

“…Рассмотрим, как будет влиять удаление участков экспериментальных данных на результаты их многомасштабного анализа. С этой целью нами был выбран нестационарный процесс, отражающий динамику церебральных сосудов головного мозга мыши [20]. Сигналы скорости церебрального кровотока регистрировались с помощью метода лазерной спекл-интерферометрии, обладающего возможностью отслеживания динамики кровотока в распределенной сети церебральных сосудов с последующим выбором области (например, крупной вены или артерии), внутри которой анализируются изменения скорости кровотока во времени.…”