Optical Power of the Isolated Human Crystalline Lens

Borja, D.; Manns, Fabrice; Ho, Arthur; Ziebarth, Noël Marysa; Rosén, Å.; Jain, Rakhi; Amelinckx, A.; Arrieta, Esdras; Augusteyn, Robert C.; Parel, Jean Marie

doi:10.1167/iovs.07-1385

Cited by 61 publications

(92 citation statements)

References 30 publications

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“…Lack of reports of the index of refraction of the capsular bag prevented us from using that value in the calculations. Instead, and in keeping with previous publications [11,12], we used a surface refractive index of 1.3709. The refractive index of aqueous was assumed to be equal to the refractive index of water (1.332 at 635 nm).…”

Section: Lens Orientationmentioning

confidence: 99%

“…The lens surface radii of curvature, and their changes with age and accommodation have been extensively measured both ex vivo, using, among other techniques, shadowphotography [11] and Optical Coherence Tomography (OCT) [12,13], and in vivo, using Purkinje imaging [14][15][16], Scheimpflug imaging [14,17], magnetic Resonance Imaging [18,19] and OCT [20]. Data ex vivo and in vivo differ primarily because the isolated lens appears in its maximally accommodated state, and therefore the young lens shows large steepening ex vivo.…”

Section: Introductionmentioning

confidence: 99%

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OCT 3-D surface topography of isolated human crystalline lenses

Sun

Birkenfeld

Castro

et al. 2014

Biomed. Opt. Express

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Quantitative 3-D Optical Coherence Tomography was used to measure surface topography of 36 isolated human lenses, and to evaluate the relationship between anterior and posterior lens surface shape and their changes with age. All lens surfaces were fitted to 6th order Zernike polynomials. Astigmatism was the predominant surface aberration in anterior and posterior lens surfaces (accounting for ~55% and ~63% of the variance respectively), followed by spherical terms, coma, trefoil and tetrafoil. The amount of anterior and posterior surface astigmatism did not vary significantly with age. The relative angle between anterior and posterior surface astigmatism axes was on average 36.5 deg, tended to decrease with age, and was >45 deg in 36.1% lenses. The anterior surface RMS spherical term, RMS coma and 3rd order RMS decreased significantly with age. In general, there was a statistically significant correlation between the 3rd and 4th order terms of the anterior and posterior surfaces. Understanding the coordination of anterior and posterior lens surface geometries and their topographical changes with age sheds light into the role of the lens in the optical properties of the eye and the lens aging mechanism.

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Section: Lens Orientationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

OCT 3-D surface topography of isolated human crystalline lenses

Sun

Birkenfeld

Castro

et al. 2014

Biomed. Opt. Express

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“…However, Figure 7 shows that this index practically does not vary with age. Possibly even this index increases progressively after 40 years, following the gradual increase in the concentration of proteins inside the lens (18) . Therefore we can consider that the solution to the riddle of accommodation and presbyopia cannot be in the crystalline.…”

Section: A New Approachmentioning

confidence: 99%

“…However, these changes were never confirmed (5,10) . The most found in studies of literature, in relation to the aging eye, is the progressive hardening of the sclera (13,18) . This fact seems to us highly suggestive to justify a new approach in the etiology of presbyopia, by directing it to the posterior pole of the eye.…”

Section: The Presbyopiamentioning

confidence: 99%

New concepts in accommodation and presbyopia

Santos-Neto

Alves

2011

Rev. bras.oftalmol.

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The authors conducted a review of classical and conflicting theories of accommodation and presbyopia. They make a critical comparison with the findings of magnetic resonance imaging (MRI) that have been developed in recent decades. Based on these studies, formulates a new approach on the subject, shifting the focus of the discussion of the lens to the posterior pole of the eye.Keywords: Ocular accommodation ; Presbyopia RESUMOOs autores revisaram as teorias clássicas e conflitantes sobre acomodação e presbiopia. E as compararam criticamente com os achados de imagem por ressonância magnética (MRI) que têm se desenvolvido nas últimas décadas. Baseado nestes estudos, formulam uma nova abordagem sobre o tema, mudando o foco da discussão do cristalino para o polo posterior do olho.

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“…This is an increase in the dioptric power of the eye that enables the image of near objects to be focused on the retina. The refractive power of the lens is strongly affected by age and ranges from about 15 diopters at birth to around 2 diopters at the age of fifty (Alió, Schimchak et al 2005;Borja, Manns et al 2008). The index of refraction for a normal lens changes from 1.40 at the center to 1.36 on the periphery and is also greatly affected by age.…”

Section: The Ocular Mediamentioning

confidence: 99%

Distribution of Light in the Human Retina under Natural Viewing Conditions

Gibert¹

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Optical Power of the Isolated Human Crystalline Lens

Cited by 61 publications

References 30 publications

OCT 3-D surface topography of isolated human crystalline lenses

OCT 3-D surface topography of isolated human crystalline lenses

New concepts in accommodation and presbyopia

Distribution of Light in the Human Retina under Natural Viewing Conditions

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