The size-dependent behavior of nanostructured ferrite is well established. Various physical properties such as magnetic, optical and electrical exhibit strong size dependence. Thus, any treatment which causes a change in size is able to modify the characteristics of ferrites. The result of this effect can be seen when these ferrites are subjected to an intense heavy ion beam which modifies the physical properties of ferrites. This modification is related to cation redistribution owing to size change in most of the cases under heavy ion irradiation. However, few recent studies show that cation redistribution may occur under ion irradiation even though no size change is observed. The objective of this review is to highlight this effect in ferrite systems which ultimately may provide ample opportunity for its potential applications.