Optical sensing for tumor detection in the liver

Evers, D.; Nachabé, Rami; Hompes, Daphne; Coevorden, Frits van; Lucassen, Gerald W.; Hendriks, Benno H. W.; Velthuysen, Marie‐Louise F. van; Wesseling, Jelle; Ruers, T.J.M.

doi:10.1016/j.ejso.2012.08.005

Cited by 53 publications

(93 citation statements)

References 38 publications

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“…3 suggest that the optical properties of tissue types contain the most discriminative information for tissue classification in the VIS wavelength range between 450 nm and 750 nm. These findings are similar to those that have been reported for different ex vivo studies on human liver tissue of tumor patients with primary cancer [14], as well as with liver metastases [17][18][19].…”

Section: Discussionsupporting

confidence: 80%

“…In addition, various studies have observed statistical differences in the oxygen saturation of blood between liver tissue and tumors [17,18,20]. Since we performed an ex vivo study, caution needs to be taken with regard to changes in oxygenation level after resection due to elimination of liver perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…These observations originate from different chromophores for both primary and secondary tumor types. Since metastases consist of abnormal cells with their origin in other organs, the amount of bile with high absorption between 400 nm and 500 nm is low [17,18,31]. Extracted from diffuse reflectance spectra, Nachabé et al [18] have shown that the amount of bile in metastatic tumor tissues is 80% lower than in healthy liver tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Spectroscopic detection of malignant tumors in liver specimens has been successfully performed for primary liver cancer [14] and liver metastases in humans [15][16][17][18][19] as well as in animal models [20,21]. In a clinical ex vivo study by Evers et al [17] liver specimen of 24 patients who underwent surgery for colorectal liver metastases were analyzed with DRS in the visible (VIS) and near infrared (NIR) spectral range.…”

Section: Introductionmentioning

confidence: 99%

“…In a clinical ex vivo study by Evers et al [17] liver specimen of 24 patients who underwent surgery for colorectal liver metastases were analyzed with DRS in the visible (VIS) and near infrared (NIR) spectral range. DRS achieved a sensitivity and specificity of 94% in discriminating liver metastases from unaffected liver parenchyma.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Keller¹,

Białecki²,

Wilhelm³

et al. 2018

Biomed. Opt. Express

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Significant numbers of liver biopsies fail to yield representative tissue samples. This study was conducted to evaluate the ability of LED-based diffuse reflectance spectroscopy to discriminate tumors from liver parenchyma. Ex vivo spectra were acquired from malignant lesions and liver parenchyma of 32 patients who underwent liver resection using a white light source and several LEDs. Integrated spectra of two combined LEDs with emission peaks at 470 nm and 515 nm were classified with 98.4% sensitivity and 99.2% specificity. The promising results could yield to a simple handheld and cost-efficient tool for real-time tissue differentiation implemented in a biopsy needle. H. Hendriks, J. Wesseling, and T. J. Ruers, "Improved identification of peripheral lung tumors by using diffuse reflectance and fluorescence spectroscopy," Lung Cancer 80(2), 165-171 (2013). 1929-1939 (2002). 194-203 (1998).

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Keller¹,

Białecki²,

Wilhelm³

et al. 2018

Biomed. Opt. Express

View full text Add to dashboard Cite

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Near‐Infrared Windows I and II Phosphors for Theranostic Applications: Spectroscopy, Bioimaging, and Light‐Emitting Diode Photobiomodulation

Huang

Rajendran

Chan

et al. 2022

Advanced Optical Materials

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The importance and practicality of near-infrared (NIR) light for the biomedical field has attached importance to the academe and industry with the development of technology. Luminescent materials with different doping strategies are promising candidates for covering near-infrared biological windows from 700 nm to 1 700 nm. The relationship between NIR light, nanophosphors, and biological tissue towards the function of diagnostic and therapy in different NIR windows is explored clearly, which corresponds to diffuse reflection spectroscopy with bioimaging and light-emitting diode (LED) photobiomodulation. The diseases can be monitored with specific chromophore absorption under the NIR light source, which also can be traced to the dynamic change of the biological environment by luminescent materials. Especially in brain diseases, cytochrome c oxidase in mitochondria as the crucial photoreceptor can be activated under NIR irradiation to achieve the non-invasive treatment of neuron protection and recovery. NIR light attributed to LED or nanophosphors show the potential of theranostic approaches in biomedical technology. Cr 3+ -and Ni 2+ -activated phosphors covering NIR windows I and II are presented with optical properties to explore the feasibility and practicability of non-invasive precise medical treatment in the future.

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Chromophore based analyses of steady‐state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption

Bydlon

Nachabé²,

Ramanujam

et al. 2014

Journal of Biophotonics

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Diffuse reflectance spectroscopy is a rapidly growing technology in the biophotonics community where it has shown promise in its ability to classify different tissues. In the steady-state domain a wide spectrum of clinical applications is supported with this technology ranging from diagnostic to guided interventions. Diffuse reflectance spectra provide a wealth of information about tissue composition; however, extracting biologically relevant information from the spectra in terms of chromophores may be more useful to gain acceptance into the clinical community. The chromophores that absorb light in the visible and near infrared wavelengths can provide information about tissue composition. The key characteristics of these chromophores and their relevance in different organs and clinical applications is the focus of this review, along with translating their use to the clinic.

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Optical sensing for tumor detection in the liver

Cited by 53 publications

References 38 publications

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Near‐Infrared Windows I and II Phosphors for Theranostic Applications: Spectroscopy, Bioimaging, and Light‐Emitting Diode Photobiomodulation

Chromophore based analyses of steady‐state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption

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