Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix

Parameswaran, Ramya; Koehler, Kelliann; Rotenberg, Manuel; Burke, Michael J.; Kim, Jungkil; Jeong, Kwang Yong; Hissa, Bárbara; Paul, Michael; Moreno, Kiela; Sarma, Nivedina A.; Hayes, Thomas P.; Sudzilovsky, Edward; Park, Hong Gyu; Tian, Bozhi

doi:10.1073/pnas.1816428115

Cited by 91 publications

(95 citation statements)

References 26 publications

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“…A substantial amount of bioelectronic work has been conducted using macroscopic devices, [ 75–77 ] but new developments allow us to modulate bioelectronic responses with high spatial resolution, from the scale of tens of nanometers [ 60,78 ] to the size of organs. [ 60,63 ] In this way it is similar to the advancements being made using optogenetic techniques that have high spatiotemporal resolution relative to systemic genetic manipulations.…”

Section: Modulationmentioning

confidence: 96%

“…An extensive body of work exists on devices that form extracellular interfaces. This includes interfaces on the scale of individual cells and colonies in 2D culture, [ 59,60 ] collections of cells cultured in 3D, [ 61,62 ] over the surfaces of organs, [ 63 ] as well as both in vitro [ 63 ] and in vivo [ 54 ] contexts.…”

Section: Interfacesmentioning

confidence: 99%

“…This has been accomplished recently with microelectrode arrays (MEAs) [ 61 ] on the scale of organoids, as well as on the tissue scale by embedding p‐i‐n SiNWs in a polymer mesh and placing the entire structure around ex vivo rat hearts. [ 63 ] In all cases, the same mechanical considerations that apply in 2D are also valid in 3D: any potential candidate device should comprise features on the cellular length scale [ 73 ] and have similar compliance to that of extracellular matrix. [ 61 ]…”

Section: Interfacesmentioning

confidence: 99%

“…[ 60 ] Similarly, silicon nanowires embedded in SU‐8 matrix have been observed to interface with ex vivo hearts. [ 63 ]…”

Section: Interfacesmentioning

confidence: 99%

“…A few recent works have used p‐i‐n SiNWs with the specific aim of modulating Ca 2+ signaling in cardiomyocytes (CMs), which is, functionally, equivalent to modulating the pace of beating in those cells. [ 54,63 ] Because CMs do not readily internalize whole NWs, the approaches presented in each work differ based on their method for forming NW‐CM interfaces.…”

Section: Modulationmentioning

confidence: 99%

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Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Schaumann

Tian

2020

Small Methods

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systems have already yielded impressive results, such as a bionic hand with sensory feedback, [11] and a closed-loop optogenetic system that can modulate bladder function in rats. [12] These developments provide us with a helpful template for the future of nano-bioelectronics. In the coming years, we expect to see a proliferation of integrated devices and closed-loop systems that incorporate nanoelectronics in biological contexts.Nanoelectronics present us with a number of features that make them particularly desirable in biological research. Nanomaterials can possess unique optical, [13] electronic, [14,15] and magnetic [16,17] properties that only become evident at sufficiently small length scales. Moreover, nanoelectronics provide the opportunity to probe the coupling of electric phenomena and physiology from the scale of tissues and organs down to the scale of individual cells and organelles (Figure 1). [18][19][20][21] The ability of these materials to target such small structures opens the door to inquiries into the pathways for electrical transduction in biology at the scale of the pertinent molecules, and to leverage those to access therapeutic targets that would otherwise be unavailable.We draw a contrast here between inorganic nanobioelectronics, which are the focus of this Progress Report, and organic nano-bioelectronics, which are also a subject of intense research. Inorganic devices in this context are typically made from semiconductor or metal materials, while organic ones are primarily carbon-based and may be derived from biological sources. Organic devices have shown great promise as bioelectronics, and we refer the reader to a small selection of the numerous excellent articles regarding nanodiamonds, [22][23][24][25][26] carbon nanotubes, [27][28][29] and graphene-based materials [15,30,31] as well as conjugated polymers [32] and biologically-derived nanomaterials. [33,34] In broad terms, the advantages of inorganic nanomaterials are that they can adopt a wide array of precisely tunable architectures and functionalities, which can be achieved through numerous techniques during synthesis. [15,[35][36][37][38] Their disadvantages include potentially high costs of manufacture, particularly with respect to noble metal precursors, [36,39] and the possibility for accumulation without degradation in cells. [40,41] Organic nanomaterials tend to have good biocompatibility when functionalized appropriately. [23,26,32,42] They also integrate well with other bioelectronic tools, either as extensions to scaffolds [32] or as the scaffolds themselves, [33] and they can minimize negative cellular responses to mechanical mismatches between the cytoskeleton and the device. [32,33] Compared to inorganic The last several years have seen a large and increasing interest in scientific developments that combine methods and materials from nanotechnology with questions and applications in bioelectronics. This follows with a number of broader trends: the rapid increase in functionality for materials at the nanoscale; a gro...

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Section: Modulationmentioning

confidence: 96%

Section: Interfacesmentioning

confidence: 99%

Section: Interfacesmentioning

confidence: 99%

“…[ 60 ] Similarly, silicon nanowires embedded in SU‐8 matrix have been observed to interface with ex vivo hearts. [ 63 ]…”

Section: Interfacesmentioning

confidence: 99%

Section: Modulationmentioning

confidence: 99%

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Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Schaumann

Tian

2020

Small Methods

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Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces

Shi

Sun

Liang

et al. 2021

Adv Funct Materials

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The highly intricate structures of biological systems make the precise probing of biological behaviors at the cellular‐level particularly difficult. As an advanced toolset capable of exploring diverse biointerfaces, high‐aspect‐ratio nanowires stand out with their unique mechanical, optical, and electrical properties. Specifically, semiconductor nanowires show much promise in their tunability and feasibility for synthesis and fabrication. Thus far, semiconductor nanowires have shown favorable results in deciphering biological communications and translating this cellular language through the nanowire‐based biointerfaces. In this perspective, the synthesis and fabrication methods for different kinds of nanowires and nanowire‐based structures are first surveyed. Next, several cellular‐level nanowire‐enabled applications in biophysical dynamics probing, physiological or biochemical sensing, and biological activity modulation are highlighted. Then, the progress of functionalized nanowires in drug delivery and bioenergy production is reviewed. Finally, the current limitations of nanowires and an outlook into the next generation of nanowire‐based devices at the biointerfaces are concluded.

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Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication

Anand,

Müller,

Nørrehvedde Jensen

et al. 2024

Adv Funct Materials

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Biomodulation facilitated by external remote fields, such as those generated by magnetic, optical, and acoustic stimuli, has emerged as an intriguing avenue for tissue biofabrication, owing to their precision and non‐invasive characteristics. The active modulation of 3D tissue structures through cellular signaling transductions, encompassing thermo‐, mechano‐, and electro‐transduction, has proven highly effective in inducing spatiotemporally controlled, 4D compositional and functional tissue maturation. This review aims to highlight the current progress and unveil the underlying mechanisms achieved with these leadless strategies. Additionally, it addresses existing challenges and opportunities associated with these distinct approaches. Finally, with a few new directions briefly outlined, it unfolds future perspectives for their continual advancement.

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Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix

Cited by 91 publications

References 26 publications

Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Biological Interfaces, Modulation, and Sensing with Inorganic Nano‐Bioelectronic Materials

Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces

Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication

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