Optical techniques for fast screening – Towards prevention of the coronavirus COVID-19 outbreak

Carvalho, Luis Felipe das Chagas e Silva de; Nogueira, Marcelo Saito

doi:10.1016/j.pdpdt.2020.101765

Cited by 29 publications

(16 citation statements)

References 4 publications

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“…The coronavirus disease 2019 (COVID-19) is the latest biological hazard provoked for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is wreaking havoc in the health, political, economic, and social sectors around the world 1 . More than 180 countries are affected by this pandemic, and despite all containment efforts, the number of COVID-19 infected people is rising above 160 million, with over three million deaths 2 , 3 .…”

Section: Introductionmentioning

confidence: 99%

ATR-FTIR spectrum analysis of saliva samples from COVID-19 positive patients

Martínez-Cuazitl

Vázquez-Zapién

Sánchez-Brito

et al. 2021

Sci Rep

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The coronavirus disease 2019 (COVID-19) is the latest biological hazard for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though numerous diagnostic tests for SARS-CoV-2 have been proposed, new diagnosis strategies are being developed, looking for less expensive methods to be used as screening. This study aimed to establish salivary vibrational modes analyzed by attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to detect COVID-19 biological fingerprints that allow the discrimination between COVID-19 and healthy patients. Clinical dates, laboratories, and saliva samples of COVID-19 patients (N = 255) and healthy persons (N = 1209) were obtained and analyzed through ATR-FTIR spectroscopy. Then, a multivariate linear regression model (MLRM) was developed. The COVID-19 patients showed low SaO2, cough, dyspnea, headache, and fever principally. C-reactive protein, lactate dehydrogenase, fibrinogen, d-dimer, and ferritin were the most important altered laboratory blood tests, which were increased. In addition, changes in amide I and immunoglobulin regions were evidenced in the FTIR spectra analysis, and the MLRM showed clear discrimination between both groups. Specific salivary vibrational modes employing ATR-FTIR spectroscopy were established; moreover, the COVID-19 biological fingerprint in saliva was characterized, allowing the COVID-19 detection using an MLRM, which could be helpful for the development of new diagnostic devices.

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Section: Introductionmentioning

confidence: 99%

ATR-FTIR spectrum analysis of saliva samples from COVID-19 positive patients

Martínez-Cuazitl

Vázquez-Zapién

Sánchez-Brito

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Novel virus SARS-CoV-2 belongs to the family Coronaviridae, genus Betacoronavirus which induces coronavirus disease in humans . The SARS (SL) virus BatCoV-RaTG13 have high sequence similarity with SARS-CoV-2 of 96%, and with other closely related to two bats derived SARS coronaviruses (bat-SL-CoVZC45 and bat-SL-CoVZXC21), having 88% over all sequence similarity with SARS-COV (de Carvalho and Nogueira, 2020;Zhou et al, 2020). Bats are speculated to be reservoirs for various emerging viruses that cause infections to humans and animals.…”

Section: Structure and Genome Of Virus And Host Interactionmentioning

confidence: 99%

Point of Care Diagnostic Devices for Rapid Detection of Novel Coronavirus (SARS-nCoV19) Pandemic: A Review

Rao

2021

Front. Nanotechnol.

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Coronaviruses are recognized as causative agents of human diseases worldwide. In Wuhan, China, an outbreak of Severe acute respiratory syndrome novel Coronavirus (SARS-nCoV-2) was reported at the end of December 2019, causing 63 million COVID cases and 1.3 million deaths globally by 2 December, 2020. The transmission risk forecasts and the SARS-nCoV-2 epidemic pattern are progressive. Unfortunately, there is no specific FDA approved drugs or vaccines available currently to treat SARS-nCoV-2. In response to nCoV-2 spread, the rapid detection is crucial for estimating the severity of the disease and treatment of patients. Currently, there are several RT-PCR based diagnostic kits available for SARS-nCoV-2 detection, which are time-consuming, expensive, need advanced equipment facilities and trained personnel. The cost of diagnosis and the unavailability of sufficient test kits may prevent to check community transmission. Furthermore, expanding the testing facilities in asymptomatic cases in hotspots require more Point of Care (PoC) devices. Therefore, fast, inexpensive, and reliable methods of detection of SARS-nCoV-2 virus infection in humans is urgently required. The rapid and easy-to-use devices will facilitate onsite testing. In this review, nucleic acid assays, serological assays, multiplex assays, and PoC devices are discussed to understand various diagnostic approaches to reduce the spread and mortality rate in the future. Aptamer based detection is most specific, inexpensive and rapid detection of SARS-nCoV-2 without laboratory tools. To the best of our knowledge more than 900 SARS-nCoV-2 test kits are in pipeline, among 395 test kits are molecular bested test kits and only few test kits are developed using Aptamer technology https://www.finddx.org/covid-19/pipeline/.

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“…In this case, alerts can be created upon face recognition by security systems. Another possible approach was previously discussed by Carvalho and Nogueira [5], where COVID-19 detection and study of its molecular origin can also be potentially performed by probing coronavirus biomarkers using vibrational spectroscopy. In this case, direct analysis of biofluid samples and cell cultures allows fast screening at crowded places.…”

Section: Biophotonics For Pandemic Control: Large-area Infection Monimentioning

confidence: 99%

Biophotonics for pandemic control: Large-area infection monitoring and microbial inactivation of COVID-19

Nogueira

2020

Photodiagnosis and Photodynamic Therapy

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Optical techniques for fast screening – Towards prevention of the coronavirus COVID-19 outbreak

Abstract:  Biomarkers are present for coronaviruses. Raman and FT-IR spectroscopy are green technologies capable of high-throughput virus sensing. J o u r n a l P r e -p r o o f

Cited by 29 publications

References 4 publications

ATR-FTIR spectrum analysis of saliva samples from COVID-19 positive patients

ATR-FTIR spectrum analysis of saliva samples from COVID-19 positive patients

Point of Care Diagnostic Devices for Rapid Detection of Novel Coronavirus (SARS-nCoV19) Pandemic: A Review

Biophotonics for pandemic control: Large-area infection monitoring and microbial inactivation of COVID-19

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