Optical theranostics and treatment dosimetry for COVID-19 lung complications: Towards increasing the survival rate of vulnerable populations

Nogueira, Marcelo Saito

doi:10.1016/j.pdpdt.2020.101892

Cited by 17 publications

(6 citation statements)

References 11 publications

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“…Commercialized AFI devices such as VELscopeÒ expand the measured emission spectra and have demonstrated ability to delineate OSCC margins and identify premalignant lesions. 25 Nonetheless, widening the emission passband lowers AFI specificity due to loss of ability to distinguish specific fluorophores. FLIM offers greater specificity by measuring fluorescence decay over several spectral bands, albeit with longer image acquisition and processing times, although DOCI can expediate this process with a simpler ratio-metric approach.…”

Section: Discussionmentioning

confidence: 99%

“…24 Poh et al also used VELscopeÒ to successfully identify 32/33 (97%) of dysplastic or cancerous biopsies in OSCC margins. 25 Significant extension of AFL beyond the clinically apparent boundary ranging from 4-25 mm was also present in many cases. The authors found that regions with AFL but normal/low-grade dysplasia on histopathology demonstrated genetic alterations associated with cancer risk on microsatellite analysis.…”

Section: Autofluorescence Imagingmentioning

confidence: 96%

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Front Matter: Volume 12818

2024

Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024

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Section: Discussionmentioning

confidence: 99%

Section: Autofluorescence Imagingmentioning

confidence: 96%

Front Matter: Volume 12818

2024

Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024

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“…In due course, even smartphone-assisted electrochemical signaling has also been suggested as a detective device [35]. Optical theranostics could identify the pulmonary severity of COVID-19 easily [36]. Non-contact nanomaterial-based optical methods have been reported to help in both the detection as well as surface disinfection of coronavirus [37].…”

Section: Covid-19 Diagnosismentioning

confidence: 99%

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Mir¹,

Wani²,

John³

et al. 2021

Advanced Chemicobiology Research

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The year 2020 witnessed a challenging period for worldwide scientists to find a suitable treatment for the deadly novel coronavirus infectious disease-2019 (nCOVID or COVID-19). The entire scientific community has been eager to develop effective vaccines and medicine against COVID-19. Despite the fact of administration of vaccination in several countries across the globe, the drug repurposing of several antiviral compounds yielded satisfactory results in recovering the affected people. As it is a known fact that vaccination alone is not the end of this pandemic, but the final treatment in terms of drugs/medicines specific to this disease is yet underway. It looks worthy to present a literature survey based on the collective information related to the drug candidates that have been repurposed, the respective theoretical evaluation, and some of the effective therapies usable in treating COVID-19. This review also describes diagnosis and vaccination availed so far. Therefore, a sequential literature extract is hereby presented starting from the detection, going through virulence, drug repositioning, virtual screening, and the final destination in the form of vaccine development. A few commercially available vaccines have also been introduced. Based on the survey, it is clear that the entire world must remain alert for any future pandemic keeping in view the successful and unsuccessful efforts practiced in the COVID-19 pandemic.

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“…For all the aforementioned reasons, a non-invasive, real-time point-of-care method to detect and accurately diagnose cancer and premalignancies at early stages could benefit patients as well as decrease the risk of oral cancer incidence and mortality. One of the most cost-effective methods to diagnose cancer is the optical biopsy [1,3,[10][11][12][13][14][15][16][17][18]. The term optical biopsy is widely used in optical spectroscopy [6,14,[19][20][21][22][23][24], which assists in the diagnostic process and analyzes optical properties [19,[25][26][27] associated with tissue biochemistry [3][4][5][6][7][8][9]14,16,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…One of the most cost-effective methods to diagnose cancer is the optical biopsy [1,3,[10][11][12][13][14][15][16][17][18]. The term optical biopsy is widely used in optical spectroscopy [6,14,[19][20][21][22][23][24], which assists in the diagnostic process and analyzes optical properties [19,[25][26][27] associated with tissue biochemistry [3][4][5][6][7][8][9]14,16,[23][24][25]. Among optical spectroscopic techniques, Raman spectroscopy is highlighted as one of the most molecular-specific methods which does not suffer interference from water absorption.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Profiles of In Vivo Oral Mucosa by Using a Portable Raman Spectroscopy System

Nogueira

Ribeiro

Pires

et al. 2021

Optics

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Most oral injuries are diagnosed by histopathological analysis of invasive and time-consuming biopsies. This analysis and conventional clinical observation cannot identify biochemically altered tissues predisposed to malignancy if no microstructural changes are detectable. With this in mind, detailed biochemical characterization of normal tissues and their differentiation features on healthy individuals is important in order to recognize biomolecular changes associated with early tissue predisposition to malignant transformation. Raman spectroscopy is a label-free method for characterization of tissue structure and specific composition. In this study, we used Raman spectroscopy to characterize the biochemistry of in vivo oral tissues of healthy individuals. We investigated this biochemistry based on the vibrational modes related to Raman spectra of four oral subsites (buccal, gingiva, lip and tongue) of ten volunteers as well as with principal component (PC) loadings for the difference between the four types of oral subsites. Therefore, we determined the biochemical characteristics of each type of healthy oral subsite and those corresponding to differentiation of the four types of subsites. In addition, we developed a spectral reference of oral healthy tissues of individuals in the Brazilian population for future diagnosis of early pathological conditions using real-time, noninvasive and label-free techniques such as Raman spectroscopy.

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Optical theranostics and treatment dosimetry for COVID-19 lung complications: Towards increasing the survival rate of vulnerable populations

Cited by 17 publications

References 11 publications

Front Matter: Volume 12818

Front Matter: Volume 12818

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Biochemical Profiles of In Vivo Oral Mucosa by Using a Portable Raman Spectroscopy System

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