Optical trapping and manipulation of micrometer and submicrometer particles

Daly, Mark; Σεργίδης, Μάριος; Chormaic, Síle Nic

doi:10.1002/lpor.201500006

Cited by 123 publications

(78 citation statements)

References 133 publications

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“…The first optical micromanipulation technology was demonstrated by Arthur Ashkin et al in 1986, a method commonly known as optical tweezers (OT). In this technique, a high numerical aperture lens is used to apply an optical gradient force to an object, allowing for the transfer of optical momentum to control its position . Optoelectronic tweezers (OET) is a related but distinct technique that was first demonstrated by Ming Wu and co‐workers in 2005, relying on photoconductor‐coated substrates that are typically insulating, but can be made to be conductive upon illuminating with light.…”

Section: Introductionmentioning

confidence: 99%

Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells

Zhang

Shakiba

Chen

et al. 2018

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Optical micromanipulation has become popular for a wide range of applications. In this work, a new type of optical micromanipulation platform, patterned optoelectronic tweezers (p‐OET), is introduced. In p‐OET devices, the photoconductive layer (that is continuous in a conventional OET device) is patterned, forming regions in which the electrode layer is locally exposed. It is demonstrated that micropatterns in the photoconductive layer are useful for repelling unwanted particles/cells, and also for keeping selected particles/cells in place after turning off the light source, minimizing light‐induced heating. To clarify the physical mechanism behind these effects, systematic simulations are carried out, which indicate the existence of strong nonuniform electric fields at the boundary of micropatterns. The simulations are consistent with experimental observations, which are explored for a wide variety of geometries and conditions. It is proposed that the new technique may be useful for myriad applications in the rapidly growing area of optical micromanipulation.

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Section: Introductionmentioning

confidence: 99%

Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells

Zhang

Shakiba

Chen

et al. 2018

Small

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“…Briefly, two different types of forces are involved: gradient forces, which pull the object toward the laser beam's focal point, and scattering forces, which push the object along the direction of the laser beam propagation. Other factors, such as Stokes’ drag force and Brownian motion, also contribute to the stability of the trap . A short description of the physics of optical trapping for isotropic and anisotropic particles is provided in the following sections.…”

Section: Basic Concepts Of Optical Trappingmentioning

confidence: 99%

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Bunea

Glückstad

2019

Laser & Photonics Reviews

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Optical trapping and manipulation of objects down to the Ångstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real‐time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever‐growing interest of shifting from simple aqueous media towards more biologically‐relevant media. Precise optical trapping and manipulation, combined with state‐of‐the‐art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping‐stone for microrobotic “surgeons.”

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“…Besides the immobilizing ability, their system could also provide control over the particle's motion in the 2D focal plane of the optical tweezers (Figure D) . Daly reviewed the advance in optical trapping and manipulation which covered lots of representative applications in cell research …”

Section: Advanced Microfluidic Techniquesmentioning

confidence: 99%

Advances in Microfluidics Applied to Single Cell Operation

Zhu

Chu

Wang

2018

Biotechnology Journal

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The field of microbiology have traditionally been concerned with and focused on studies at the population level. Microfluidic platforms have emerged as important tools for biology research at a small scale, even down to a single cell level. The spatial and temporal control of cells and stimuli transported by microfluidic channels in well-designed microsystems realized the studies of specific cells in a controlled microenvironment. The true cellular physiology responses, which are obtained mostly by inference from population-level data, could be revealed in this way. Nowadays, significant applications like cell culture, analysis, sorting, genomics, and proteomics at the single cell level have been achieved in microfluidic chips. Highly integrated microfluidic systems with complete bio-analytic functions are also coming forth and of great promise for single cell related physiology, biomedical, and high throughput screening research. Herein, the leads of technologies applied to single cell operation are reviewed. Challenges and potentials of these works are also summarized, to highlight fields for further research.

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Optical trapping and manipulation of micrometer and submicrometer particles

Cited by 123 publications

References 133 publications

Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells

Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Advances in Microfluidics Applied to Single Cell Operation

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