Optical two-beam traps in microfluidic systems

Berg-Sørensen, Kirstine

doi:10.7567/jjap.55.08ra01

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…For example, cells deform and actively change when an external force is exerted, providing a powerful route for labelfree phenotyping and giving important insight into the development in organs and tissues in three dimensions and in vivo. In this respect, calibrated optical and acoustic forces can be applied at the lower end of the force range, with additional mechanical loading (for example, fluidic forces [97] or atomic-force-microscopy tips) used to increase the force exerted. A prime example of optical forces used in this way is the 'optical stretcher' [98].…”

Section: H1] Manipulation Combined With Imagingmentioning

confidence: 99%

Comparing acoustic and optical forces for biomedical research

2020

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The application of acoustic and optical waves to exert non-contact forces on microscopic and mesoscopic objects has grown considerably in importance in the past few decades. Different physical principles govern the acoustic and optical forces, leading to diverse biomedical applications. Biocompatibility is crucial, and useful optical and acoustic forces can be applied in devices that maintain local heating to acceptable levels. Current acoustic and optical devices work on complementary length scales, with both modalities having useful capabilities at the scale of the cell. Optical devices also cover sub-cellular scales and acoustic devices super-cellular scales. This complementarity has led to the emergence of multi-mode manipulation, often with integrated imaging. In this Technical Review, we provide an overview of optical and acoustic forces, before comparing and contrasting the use of these modalities, or combinations thereof, in terms of sample manipulation and suitability for biomedical studies. We conclude with our perspective on the applications in which we expect to see notable developments in the near future. KEY POINTS • Acoustic and optical forces are governed by different physical principles, but both enable the application of non-contact forces to biomedically important objects such as cells and microorganisms. • Acoustic and optical forces in the pico-Newton to nano-Newton range can be applied to a typical cell, with optical devices having capabilities extending below this scale and acoustic devices above. • Biocompatibility cannot be assumed as both modalities can produce local heating; however, careful device design has led to many examples of biocompatible devices. • Biomedical applications of optical and acoustic devices are rapidly increasing and include manipulation, patterning and mechanical probing, often combined with imaging. • The number of applications is expected to increase, and we anticipate more examples of multimode or hybrid devices to emerge, increasingly sophisticated integration of imaging and the development of more versatile and fully reconfigurable manipulation systems.

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Section: H1] Manipulation Combined With Imagingmentioning

confidence: 99%

Comparing acoustic and optical forces for biomedical research

2020

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“…Soft polymer materials (PDMS) Single mode optical fibers Acoustic forces 29 Table 1 summarizes the designs investigated in our previous work, already to a large extent reviewed in Ref. 30. Details of the experimental setup may be found in the papers referenced in the table.…”

Section: Design Considerations For Optical Stretcher Assaysmentioning

confidence: 99%

Deformation of single cells - optical two-beam traps and more

Nielsen

Rungling

Dziegiel

et al. 2019

Complex Light and Optical Forces XIII

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“…Microfluidic devices found their capacity as microscale and nanoscale platforms in many field of science such as biotechnology, physics, chemistry, and biomedicine . Moreover, this device can provide portable and automate system with high control on microenvironment .…”

Section: Introductionmentioning

confidence: 99%

Different types of electrospun nanofibers and their effect on microfluidic‐based immunoassay

Mahmoudifard

Vossoughi

Soleimani

2019

Polymers for Advanced Techs

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Protein capturing on polymeric substrate of microfluidic devices is a key factor for the fabrication of immunoassay with high sensitivity. In this work, simple and versatile technique of electrospinning was used to produce electrospun nanofibrous membranes (e.NFMs) with high surface area as a substrate for microfluidic‐based immunoassay to increase sensitivity. It was found that the simultaneous use of e.NFM and 1‐Ethylethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide/N‐Hydroxysuccinimide hydroxysuccinimide as coupling agent has synergic effect on antigen immobilization onto the microchannels. It was found that the oxygen plasma technique for the creation of oxygen containing functional group like carboxyl and hydroxyl causes extreme leakage of solution through the microchannels. Thus, due to capillary effect, it is impossible to use hydrophilic substrate to modify microchannels. In order to compensate this problem, it is propose to utilize other type of polymer for the fabrication of nanofiber to answer this important question that if it is possible to enhance the sensitivity of immunoassay just by changing the polymer type? For this purpose, four different polymers, namely, polycaprolactone, poly lactic‐co‐glycolic acid, poly L‐lactic acid, and polyethersolfone were used as the based material for e.NFM fabrication. Results showed that compared with plain poly (dimethylsiloxane) surface of microchannels, poly lactic‐co‐glycolic acidand poly L‐lactic acid, which inherently contain end‐group of carboxyl in their chemical structure, can improve the protein immobilization, which leads to immunoassay signal enhancement through 1‐ethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide/N‐hydroxysuccinimide coupling chemistry, significantly.

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Optical two-beam traps in microfluidic systems

Cited by 5 publications

References 26 publications

Comparing acoustic and optical forces for biomedical research

Comparing acoustic and optical forces for biomedical research

Deformation of single cells - optical two-beam traps and more

Different types of electrospun nanofibers and their effect on microfluidic‐based immunoassay

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