2011
DOI: 10.1038/ncomms1211
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Optical virtual imaging at 50 nm lateral resolution with a white-light nanoscope

Abstract: The imaging resolution of a conventional optical microscope is limited by diffraction to ~ 200 nm in the visible spectrum. Efforts to overcome such limits have stimulated the development of optical nanoscopes using metamaterial superlenses, nanoscale solid immersion lenses and molecular fl uorescence microscopy. These techniques either require an illuminating laser beam to resolve to 70 nm in the visible spectrum or have limited imaging resolution above 100 nm for a white-light source. Here we report a new 50-… Show more

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Cited by 728 publications
(628 citation statements)
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“…During this process, the photonic nanojets (i.e., a higher-intensity optical field located below the sphere that has a higher density spot beyond the optical diffraction limit) are generated, similar to the case in the reflection mode. 16 The nano-jets arrive on the sample surface and illuminate the area below the microsphere at a high intensity and a high resolution, beyond the diffraction limit. This nano-jet super-resolution focusing phenomenon has been applied for laser nano-fabrication.…”
Section: Smon Imaging Mechanismsmentioning
confidence: 99%
See 2 more Smart Citations
“…During this process, the photonic nanojets (i.e., a higher-intensity optical field located below the sphere that has a higher density spot beyond the optical diffraction limit) are generated, similar to the case in the reflection mode. 16 The nano-jets arrive on the sample surface and illuminate the area below the microsphere at a high intensity and a high resolution, beyond the diffraction limit. This nano-jet super-resolution focusing phenomenon has been applied for laser nano-fabrication.…”
Section: Smon Imaging Mechanismsmentioning
confidence: 99%
“…In addition, the SMON imaging plane was found to not be on the target surface but well below it; i.e., the images are virtual. 16 The imaging plane position and additional image magnification factor introduced by the microsphere can be determined by considering the spherical lens effect and spherical aberration, as follows:…”
Section: Smon Virus Imaging L Li Et Almentioning
confidence: 99%
See 1 more Smart Citation
“…Wang et al have developed a super-resolution imaging technique using a microsphere placed on a measured surface [12]. This method can image only the surface underneath the microsphere, so a microsphere is displaced using a micropipette [13].…”
Section: Principle Of Surface Imagingmentioning
confidence: 99%
“…By adding an annular aperture 40 to the nSIL, additional optimization of the resolution is achievable as the diffraction lobes are narrowed and subcritical rays are blocked-avoiding aberrations. To further enhance the resolution, in 2011, Wang et al 41 modified the geometrical shape of the nSIL to be a whole microsphere and illuminated it with white light (Figure 4a). The imaging procedure had changed to a virtual one that was capable of obtaining 50-nm resolution (Figure 4b and 4c).…”
Section: Detection Of the Evanescent Wavementioning
confidence: 99%