Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology

Kikuchi, Yuji; Sato, K.; Ohki, Hiroshi; Kaneko, Toshihiro

doi:10.1016/0026-2862(92)90082-z

Cited by 132 publications

(97 citation statements)

References 12 publications

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“…Mechanical emulsification can be carried out using high-pressure homogenizers, rotor-stator systems, ultrasound homogenizers [1] and novel microporous emulsification systems based on a microporous membrane of different structure [2] or regular-sized silicon microchannels fabricated by semiconductor technology [3]. In a microporous emulsification system, small droplets are directly formed by the permeation of dispersed phase through the uniform micro -pores or -channels into moving continuous phase.…”

Section: Introductionmentioning

confidence: 99%

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

Vladisavljević

Lambrich

Nakajima

et al. 2004

Colloids and Surfaces A: Physicochemical and Engineering Aspect

115

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Section: Introductionmentioning

confidence: 99%

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

Vladisavljević

Lambrich

Nakajima

et al. 2004

Colloids and Surfaces A: Physicochemical and Engineering Aspect

115

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“…In 1992, Kikuchi et al (1992) [32]. Using a temperature-untreated sample as a control, aliquots of freshly drawn venous blood were subjected to mild heating at 37°C, 40°C, 42°C, 45°C and 48°C for 30 min.…”

Section: Hemichrome Emergence and Subsequent Formation Of Heinz Bodiementioning

confidence: 99%

New Mode (Molecular-Sensing) of Heinz Body Formation Mechanisms Inherent in Human Erythrocytes: Basis for Understanding of Clinical Aspects of Drug-Induced Hemolytic Anemia and the Like

Sugawara¹

2013

J Bioanal Biomed

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The human hemoglobin (Hb) molecule (α 2 β 2 ) has two types of α-β interface (i.e., α 1 -β 1 [and α 2 -β 2 ] and α 1 -β 2 [and α 2 -β 1 ]). The latter α 1 -β 2 (and α 2 -β 1 ) interface is associated with cooperative O 2 binding, and exhibits principal roles if the molecule goes from its deoxygenated to oxygenated quaternary structure. The role of the former α 1 -β 1 (and α 2 -β 2 ) interface has been unclear for a long time. In this regard, important and intriguing observations have been accumulating, so that a new gaze can be focused on the α 1 -β 1 (and α 2 -β 2 ) interface. Our most recent findings suggest that the α 1 -β 1 (and α 2 -β 2 ) interface may exert delicate control of the intrinsic tilting capability of the distal (E7) His residues (i.e., α58His (E7) in the α chain and β63His (E7) in the β chain) depending on internal and external conditions of the erythrocyte to lead to degradation of Hb to hemichrome, and subsequent clustering of Heinz bodies within the erythrocyte. In the spleen, rigid intra-erythrocytic hemichrome inclusions (Heinz bodies) act as "sticking points", so Heinz body-containing red cells become trapped and undergo hemolysis. In this article, we first provide our necessary basic experimental findings that led us to grasp molecular biosensing mechanisms inherent in human erythrocytes for the appreciation of aging and determination of their lifespan, and summarize their roles in physiology. We then discuss how these accomplishments contribute to deeper understanding of clinical aspects of drug-induced hemolytic anemia, defects in the intra-erythrocytic reducing system and unstable Hb disease, in which the mechanisms for acute hemolytic crisis cannot be explained on the basis of conventional views.

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“…When human whole blood is flowed into the microchannels, platelet aggregation was observed after channel passage due to activation of platelet. This www.intechopen.com chip is used for the evaluations of the shear stress sensitivity of platelets, the adhesion of white blood cells and the hardness of red blood cells from blood transit time as well as the blood flow images (Kikuchi et al, 1992;Kikuchi et al, 1994). Hydrophilic treatment on the microchannels was required to flow the blood smoothly and not to adhesion of biomaterials.…”

Section: Mce-esi-ms Microchipmentioning

confidence: 99%

Low-Temperature Polymer Bonding Using Surface Hydrophilic Treatment for Chemical/Bio Microchips

Shinohara¹,

Mizuno²,

Shoji³

et al. 2010

Solid State Circuits Technologies

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Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology

Cited by 132 publications

References 12 publications

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

Production of O/W emulsions using SPG membranes, ceramic α-aluminium oxide membranes, microfluidizer and a silicon microchannel plate—a comparative study

New Mode (Molecular-Sensing) of Heinz Body Formation Mechanisms Inherent in Human Erythrocytes: Basis for Understanding of Clinical Aspects of Drug-Induced Hemolytic Anemia and the Like

Low-Temperature Polymer Bonding Using Surface Hydrophilic Treatment for Chemical/Bio Microchips

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