Optically monitored segmented flow for controlled ultra-fast mixing and nanoparticle precipitation

Erfle, Peer; Riewe, Juliane; Bunjes, Heike; Dietzel, Andreas

doi:10.1007/s10404-017-2016-2

Cited by 27 publications

(32 citation statements)

References 35 publications

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“…Indeed, the derived equations are analogous to non-linear elastic plate theory (see, e.g., [16]). It is worth noting that inertial effects appears even for quite small Reynolds numbers Re ∼ ε 4 .…”

Section: Discussionmentioning

confidence: 99%

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Asymptotic analysis of thin viscous plate model

Melikhov¹,

Popov²

2018

Nanosystems: Phys. Chem. Math.

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A cell membrane is a very complex medium, which is difficult to study. One of the simplest approaches is to assume it purely elastic or purely viscous. In this paper, we follow the second assumption and derive mathematical model of nearly-planar viscous plate evolving under action of applied forces. The obtained model is non-linear and covers both stretching and bending of the membrane. In contrast to analogous works on viscous sheets, we use a unique scale for velocity components and take a few first terms in asymptotic expansion. The developed approach can be used for description of the cell membrane with nanoparticles inserted.

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Section: Discussionmentioning

confidence: 99%

“…Results of [3] are relevant for water desalination applications. Paper [4] describes a system for ultra-fast mixing of solvents with aqueous fluids and subsequent precipitation of poorly water soluble drug nanoparticles or colloidal carrier particles. Work [5] describes various applications of carbon nanotubes in nanofluidic-based devices.…”

Section: Introductionmentioning

confidence: 99%

Asymptotic analysis of thin viscous plate model

Melikhov¹,

Popov²

2018

Nanosystems: Phys. Chem. Math.

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“…Furthermore, the laser machining system includes a galvanometer scanner system (Scanlab RTC 5, Scanlab GmbH, Puchheim, Germany) embedded into a micromachining platform (Microstruct-C, 3DMicromac, Chemnitz, Germany). In the past, this laser system was already used to fabricate devices for nanoparticle precipitation [ 28 ], the analysis of pancreatic islets [ 29 ], point-of-care tests from nitrocellulose [ 30 ], and shape memory alloy (SMA) actuators made from NiTi material [ 31 ]. The fabrication process utilized in this work is shown in Figure 4 :…”

Section: Methodsmentioning

confidence: 99%

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

et al. 2018

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Microfluidic quartz crystal microbalances (QCM) can be used as powerful biosensors that not only allow quantifying a target analyte, but also provide kinetic information about the surface processes of binding and release. Nevertheless, their practical use as point-of-care devices is restricted by a limit of detection (LoD) of some ng/cm². It prohibits the measurement of small molecules in low concentrations within the initial sample. Here, two concepts based on superparamagnetic particles are presented that allow enhancing the LoD of a QCM. First, a particle-enhanced C-reactive protein (CRP) measurement on a QCM is shown. The signal response could be increased by a factor of up to five by utilizing the particles for mass amplification. Further, a scheme for sample pre-preparation utilizing convective up-concentration involving magnetic bead manipulation is investigated. These experiments are carried out with a glass device that is fabricated by utilizing a femtosecond laser. Operation regimes for the magnetic manipulation of particles within the microfluidic channel with integrated pole pieces that are activated by external permanent magnets are described. Finally, the potential combination of the concepts of mass amplification and up-concentration within an integrated lab-on-a chip device is discussed.

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“…After laser ablation, the wafer was processed in a clean environment and steeped in a glass etching solution (Phosphoric acid, Hydrofluoric acid and water, 20:6:9) for 90 s in order to smoothen the ablation facets and dissolve residual glass fragments. The ablated wafer and another blank wafer were then inserted in a wafer cleaning machine (Fairchild Convac, Neuenstadt, Germany) that sprays pressurized water and dispenses a mixture of H 2 SO 4 and H 2 O 2 for cleaning and surface activation before thermally bonding the two wafers by placing them in a muffle oven at 620 • for a duration of 6 h. The post-ablation process was adopted from an earlier work by Erfle et al [44,45]. Figure 2 shows laser microscopy images before and after dipping the wafer in glass etching solution.…”

Section: Microfluidic Disc Designmentioning

confidence: 99%

“…surface activation before thermally bonding the two wafers by placing them in a muffle oven at 620° for a duration of 6 h. The post-ablation process was adopted from an earlier work by Erfle et al [44,45]. Figure 2 shows laser microscopy images before and after dipping the wafer in glass etching solution.…”

Section: Microfluidic Disc Designmentioning

confidence: 99%

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

et al. 2020

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The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 µm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 µm particles and 93.75% for the 5 µm particles.

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Optically monitored segmented flow for controlled ultra-fast mixing and nanoparticle precipitation

Cited by 27 publications

References 35 publications

Asymptotic analysis of thin viscous plate model

Asymptotic analysis of thin viscous plate model

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

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