“…Gli repressor forms, particularly Gli3R, are known to inhibit canonical Wnt signaling by direct interaction with beta-catenin (Ulloa et al, 2007). Shh antagonism of Wnt (Ding and Wang, 2017) may additionally be contributed by SFRP (He et al, 2006;Katoh and Katoh, 2006), a regulated target of Sox17 (Chew et al, 2011). SFRP1 regulation of Wnt3a (Galli et al, 2006) or GSK3beta activity (Peng et al, 2019) in turn alters beta-catenin localization and function (Peng et al, 2019).…”