In this paper, the design process of compact flexible ultra-wideband (UWB) antenna using various substrate materials such as FR4, Kapton, and Rogers RT5880 is discussed and experimentally investigated. The proposed antenna is structured as a flexible model that can conform to suite the human body surface to be suitable for wireless body area network (WBAN) applications. The performance parameters of the antenna have been evaluated by using CST Microwave Studio software and very similar results have been achieved by applying FR4, Kapton, and Rogers RT5880 substrates, but latest layer provides the optimized results. Therefore, the Rogers RT5880 substrate was chosen to be experimentally tested for antenna realization and validating the simulated results. It was exhibited that very good agreement between the simulated and measured results have been obtained. It is shown that, the proposed antenna with advantages of miniaturized dimensions of 22 × 28 × 1.6 mm 3 , dual band capability to operate over 4. GHz spectrums, high gain above 5.5 dBi for both bands, omnidirectional radiation patterns, simple layout, ease of manufacture, and cost effective can be good nominate for wireless applications such as wireless body area network (WBAN).