Optically sizing single atmospheric particulates with a 10-nm resolution using a strong evanescent field

Yu, Xiaonan; Zhi, Yanyan; Tang, Shui‐Jing; Li, Beibei; Gong, Qihuang; Qiu, Cheng‐Wei; Xiao, Yun‐Feng

doi:10.1038/lsa.2018.3

Cited by 74 publications

(45 citation statements)

References 62 publications

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“…Detection of a single nanoparticle is of enormous importance in early-stage disease diagnosis, explosive materials detection and semiconductor manufacturing. Optical sensors such as nano-waveguide sensors [69][70][71][72], WGM microcavity sensors [73], and PhC microcavity sensors [74,75] have attracted great attention due to high S, low cost and small size, which has been successfully used for single nanoparticle detection. Moreover, the sensitivity and detection limit are the major factors to characterize the performance of optical sensors.…”

Section: Single Nanoparticle Trapping and Detectionmentioning

confidence: 99%

Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

et al. 2020

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The ability to detect nanoscale objects is particular crucial for a wide range of applications, such as environmental protection, early-stage disease diagnosis and drug discovery. Photonic crystal nanobeam cavity (PCNC) sensors have attracted great attention due to high-quality factors and small-mode volumes (Q/V) and good on-chip integrability with optical waveguides/circuits. In this review, we focus on nanoscale optical sensing based on PCNC sensors, including ultrahigh figure of merit (FOM) sensing, single nanoparticle trapping, label-free molecule detection and an integrated sensor array for multiplexed sensing. We believe that the PCNC sensors featuring ultracompact footprint, high monolithic integration capability, fast response and ultrahigh sensitivity sensing ability, etc., will provide a promising platform for further developing lab-on-a-chip devices for biosensing and other functionalities.Micromachines 2020, 11, 72 2 of 20 microcavities confine the light in a small volume, leading to significant enhancement of light-matter interaction, resulting in ultra-high sensitivity (S) and a low detection limit. When subject to slight environmental changes, the spectral properties change can be obtained, e.g., resonator wavelength shift [20][21][22] and mode broadening [23].The main types of optical microcavities include whispering gallery mode (WGM) cavities, Fabry-Perot (F-P) cavities and photonic crystal (PhC) cavities [24]. Among these, PhC cavities have been investigated as advantageous platforms due to their ultra-high Q/V enabling the enhancement of lightmatter interactions. Particularly, compared with two-dimensional (2D) PhC cavities, one-dimensional photonic crystal nanobeam cavities (1D-PCNCs) attract great attention for their ultra-sensitive optical sensing and lab-on-a-chip applications, owing to their ultra-compact size, ultra-small mode volume, high integrability with bus-waveguide and excellent complementary metal-oxide-semiconductor (CMOS) compatible properties [25][26][27][28][29][30][31][32][33].In this review, we will focus on nanoscale optical sensing based on 1D-PCNCs. The structure of the review is organized as follows. A comprehensive overview about basic properties and sensing mechanisms of 1D-PCNCs sensors is discussed in Section 2. In Section 3, firstly, we introduce the efforts to pursue ultra-high figure of merit (FOM) in refractive index (RI) sensing based on 1D-PCNCs. Secondly, we outline the applications of 1D-PCNC sensors on single nanoparticle and label-free molecule (viruses, proteins and DNAs) detection. Thirdly, a monolithic integrated 1D-PCNC sensor array for multiplexed sensing is introduced explicitly. In addition, we present other sensing applications of 1D-PCNC sensors such as temperature sensing and optomechanical sensing, etc. Next, we review the nanofabrication and coupling techniques in the development of 1D-PCNC sensors in Section 4. Finally, we draw a brief conclusion. Figure 2. (a) Schematic of photonic circuits. The green lines, red boxes and black boxes represe...

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Section: Single Nanoparticle Trapping and Detectionmentioning

confidence: 99%

Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

et al. 2020

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“…Therefore, it is confirmed that the stepwise shifting of ~0.1 nm in transmission spectrum is induced by the binding of individual ErbB2 molecules to the microfiber surface. Thus, the as-prepared sensor achieves biomarker detection at the single-molecule level (28,29).…”

Section: Erbb2 Sensingmentioning

confidence: 99%

Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface

Huang

Guan

et al. 2019

Sci. Adv.

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For early-stage diagnostics, there is a strong demand for sensors that can rapidly detect biomarkers at ultralow concentration or even at the single-molecule level. Compared with other types of sensors, optical microfibers are more convenient for use as point-of-care devices in early-stage diagnostics. However, the relatively low sensitivity strongly hinders their use. To this end, an optical microfiber is functionalized with a plasmonic nanointerface consisting of black phosphorus-supported Au nanohybrids. The microfiber is able to detect epidermal growth factor receptor (ErbB2) at concentrations ranging from 10 zM to 100 nM, with a detection limit of 6.72 zM, enabling detection at the single-molecule level. The nanointerface-sensitized microfiber is capable of differentiating cancer cells from normal cells and treating cancer cells through cellular photothermal therapy. This work opens up a possible approach for the integration of cellular diagnosis and treatment. -O. Guan, Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface. Sci. Adv. 5, eaax4659 (2019).

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“…Reprinted from refs. (a), (b), (c), (d), (e), (f), (g), (h), and (i) with permission: CC‐BY 4.0 open access publication (a,g,i); Copyright 2015 and 2017, American Association for the Advancement of Science (b,c,d); Copyright 2001 and 2012, Royal Society of Chemistry (e,f); Copyright 2017, Springer Nature (h).…”

Section: Applications In Field Research and Diagnosticsmentioning

confidence: 99%

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

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performed at home and results can be integrated by online interfaces. [5] The test results and diagnostic information can be analyzed by the medical professionals from remote locations, improving the connectivity of central hubs to the public venues.Numerous scientific discoveries have been made in advanced settings and wellequipped laboratories. The necessity and complexity of these environments limit access to research equipment worldwide. Thus, decentralization of research laboratories has become an alternative solution to improve access to experimentation in field conditions. For instance, a paper origami microscope [6] that fit into a palm of a student made a powerful investigation tool for environment and materials. A detailed analysis of sound recordings by smartphones enabled identification of distinct mosquitoes. [7] These fielddeployable devices and platforms have stimulated emergence of citizen scientists, a population that collectively performs scientific inquiries in public settings.Rich biomolecular measurements from field-portable devices improve the quality of results in terms of accuracy and depth. Monitoring multiple blood markers has enabled diagnostic precision and thorough scientific investigation of blood constituent in patients. Therefore, field-deployable devices should ideally have multiplexed detection of target specimens. Design of such multiplexed detection technologies requires decent complexity at low cost for wide-scale adoptability.In this article, we provide an overview of field-compatible devices with high parameter analysis capabilities for both health monitoring purposes and scientifically enlightening Global health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single-plex assays due to ease-of-use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point-of-care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowdsourced solutions, and robust user interfaces will become an integral ...

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Optically sizing single atmospheric particulates with a 10-nm resolution using a strong evanescent field

Cited by 74 publications

References 62 publications

Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

Single-molecule detection of biomarker and localized cellular photothermal therapy using an optical microfiber with nanointerface

Portable Multiplex Optical Assays

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