Optimal Aloe vera encapsulated PCL/Gel nanofiber design for skin substitute application and the evaluation of its in vivo implantation

Baghersad, Somayeh; Hivechi, Ahmad; Bahrami, S. Hajir; Milan, Peiman Brouki; Siegel, Ronald A.; Amoupour, Moein

doi:10.1016/j.jddst.2022.103536

Cited by 14 publications

(7 citation statements)

References 54 publications

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“…In recent publications, two types of solvents have been used for ES of PCL/Gt composites, fluorinated alcohols [ 29 , 30 , 31 , 33 , 35 , 36 , 39 , 41 , 43 , 45 , 49 , 51 ] and carboxylic acids (AcOH, HCOOH) [ 32 , 34 , 37 , 38 , 40 , 42 , 46 , 47 , 48 , 50 , 65 ]. In the present study, we set ourselves the task to provide rather high (but not excessive) chemical bonding between NHS-functionalized PCL and Gt macromolecules as a result of the reaction of NHS-terminated PCL with amino groups of Gt.…”

Section: Resultsmentioning

confidence: 99%

“…Gelatin (Gt) is a hydrophilic and non-immunogenic natural-origin polymer that promotes cell adhesion, differentiation, and proliferation [ 21 ]. PCL/Gt-based ES composite nano- and microfibers seem to be promising for different biomedical applications [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], and the studies of PCL/Gt ES scaffolds have intensified significantly in recent years [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

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Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

et al. 2022

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Composite biocompatible scaffolds, obtained using the electrospinning (ES) technique, are highly promising for biomedical application thanks to their high surface area, porosity, adjustable fiber diameter, and permeability. However, the combination of synthetic biodegradable (such as poly(ε-caprolactone) PCL) and natural (such as gelatin Gt) polymers is complicated by the problem of low compatibility of the components. Previously, this problem was solved by PCL grafting and/or Gt cross-linking after ES molding. In the present study, composite fibrous scaffolds consisting of PCL and Gt were fabricated by the electrospinning (ES) method using non-functionalized PCL1 or NHS-functionalized PCL2 and hexafluoroisopropanol as a solvent. To provide covalent binding between PCL2 and Gt macromolecules, NHS-functionalized methyl glutarate was synthesized and studied in model reactions with components of spinning solution. It was found that selective formation of amide bonds, which provide complete covalent bonding of Gt in PCL/Gt composite, requires the presence of weak acid. With the use of the optimized ES method, fibrous mats with different PCL/Gt ratios were prepared. The sample morphology (SEM), hydrolytic resistance (FT-IR), cell adhesion and viability (MTT assay), cell penetration (fluorescent microscopy), and mechanical characteristics of the samples were studied. PCL2-based films with a Gt content of 20 wt% have demonstrated the best set of properties.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

et al. 2022

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“…In this study, side-by-side electrospinning was employed to create Janus nanofibers by incorporating CA and Gel in a single nanofiber, with Gel as a hydrophilic polymer that adds many hydroxyl and amino groups to Janus nanofibers. Janus nanofibers' weak CA hydrophilicity was enhanced [32,33]. This ultimately leads to improved biocompatibility of the Janus nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Investigation of Cellulose Acetate/Gelatin Janus Nanofiber Wound Dressings Loaded with Zinc Oxide or Curcumin for Enhanced Antimicrobial Activity

Huang,

Zeng,

et al. 2024

Membranes

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The skin, as the largest organ, serves as a protective barrier against external stimuli. However, when the skin is injured, wound healing becomes a complex process influenced by physiological conditions, bacterial infections, and inflammation. To improve the process of wound healing, a variety of wound dressings with antibacterial qualities have been created. Electrospun nanofibers have gained significant attention in wound dressing research due to their large specific surface area and unique structure. One interesting method for creating Janus-structured nanofibers is side-by-side electrospinning. This work used side-by-side electrospinning to make cellulose acetate/gelatin Janus nanofibers. Curcumin and zinc oxide nanoparticles were added to these nanofibers. We studied Janus nanofibers’ physicochemical characteristics and abilities to regulate small-molecule medication release. Janus nanofibers coated with zinc oxide nanoparticles and curcumin were also tested for antibacterial activity. The Janus nanofibers with specified physicochemical characteristics were successfully fabricated. Nanofibers released small-molecule medicines in a controlled manner. Additionally, the Janus nanofibers loaded with curcumin exhibited excellent antibacterial capabilities. This research contributes to the development of advanced wound dressings for promoting wound healing and combating bacterial infections.

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“…Throughout history, humans have used native AV gel, which has been shown to have exceptional properties in the wound-healing process and in promoting tissue regeneration. The huge potential of AV gel is due to the advantages of the biocompatible, bioavailable, and biodegradable matrix, as well as the ability to heal wounds easily and effectively without leaving scars [52,61,62]. Native AV gel not only releases bioactive components but also moisturizes the wound to increase flexibility, acts as a barrier against foreign microbes, and helps reduce pain at nerve endings [21].…”

Section: Introductionmentioning

confidence: 99%

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Chelu

Musuc

Popa

et al. 2023

Gels

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Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of Aloe vera-based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of Aloe vera-based hydrogels are discussed. Mechanisms of therapeutic agents released from Aloe vera-based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of Aloe vera-based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into Aloe vera-based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of Aloe vera-based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of Aloe vera-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.

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Optimal Aloe vera encapsulated PCL/Gel nanofiber design for skin substitute application and the evaluation of its in vivo implantation

Cited by 14 publications

References 54 publications

Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

Preparation and Investigation of Cellulose Acetate/Gelatin Janus Nanofiber Wound Dressings Loaded with Zinc Oxide or Curcumin for Enhanced Antimicrobial Activity

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

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