Optimal anesthesia for neurosurgical operations with intraoperative neurophysiological monitoring. Part I. Patients without previous epileptic syndrome

Genetic variation of rs12918566 affects GRIN2A expression and is associated with spontaneous movement response during sevoflurane anesthesia induction

“…Associations between candidate gene polymorphisms and spontaneous movement responses were analyzed by Plink using a logistic model. Age and ETAC covariates were adjusted as previous studies reported they were associated with volatile anesthetic drug responses (Dwyer et al., 1990; Moshchev & Lubnin, 2014; Sakai et al., 2005). The additive, dominant, and recessive models indicated significant associations of GRIN2A rs12918566 and spontaneous movement (odds ratio (OR) (95% confidence limit (CI)): 0.58 (0.42–0.80), p =.00086; OR (95% CI): 0.51 (0.31–0.84), p =.0075; OR (95% CI): 0.47 (0.27–0.81), p =.0060, receptively).…”